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Biomedical subjects

J Erben

Publications and source records attributed to J Erben.

At least 55 records · Page 3Linked to original sources
PubMed1985

Fluoride metabolism and renal osteodystrophy in regular dialysis treatment.

Fluoride in plasma, urine and bone tissue ash were estimated using a fluoride-ion electrode in 20 control persons (CP), 32 patients with compensated chronic renal failure (CRFP) and 59 patients in RDT (RDTP). The increase in plasma fluoride (CP: 2.4 +/- 1.4, CRFP: 6.5 +/- 2.2, RDTP: 12.3 +/- 4.5 mumol/L) and bone fluoride (CP: 55.1 +/- 31, CRFP: 99.9 +/- 31.2, RDTP: 339.1 +/- 150.6 mumol/g) significantly correlated with the decrease of residual glomerular filtration rate (RGFR), in RDT with the number of haemodialysis, so that the maximum increase in fluoride was found in completely anuric patients (379.7 +/- 153 mumol/g). The increase in fluoride retention was intensified by body retention of considerable amounts of fluoride each dialysis (the fluoridated dialysate increased the post-dialysis plasma fluoride by 195%). Development of bone fluorose known to develop with a bone fluoride greater than 180 mumol/g was not found in any of 40 iliac crest trephine bone biopsy specimens. No correlation was found between laboratory and histological findings of renal osteodystrophy and plasma or bone fluoride. No patient developed spontaneous fractures even after 11 years of using fluoridated dialysate. In conclusion, this report indicates that fluoride might have a protective effect against the progression of renal osteodystrophy in patients with high retention values. The longer the exposure of RDT patients to the fluoridated dialysate, the greater the bone fluoride concentration.

Adult↗
PubMed1985

Is there an increased risk of colorectal cancer after cholecystectomy?

The incidence of cholecystectomy was not higher in 525 colorectal cancer patients than in subjects without colorectal cancer of the same age and sex living in the same region. If we did not include the persons who underwent cholecystectomy 1 or 2 years before the diagnosis or the examination was made, the number of cholecystectomy patients was the same in both groups. Right-sided and left-sided localizations of colon cancer after cholecystectomy did not differ from those without cholecystectomy. The tendency to right-sided colon cancer in women who have undergone cholecystectomy was not significant. Patients after cholecystectomy have no higher risk of colorectal cancer than persons without cholecystectomy.

Adult↗
PubMed1985

[Natural gas in forensic medicine].

In the experiment in rats the effect of earth gas on the living organism was followed. In comparison with nitrogen representing the largest portion of atmospheric gases, the earth gas did not manifest an increased toxicity. The results of the experiment were compared with case reports from practice, where the persons and died in connection with using the earth gas, most frequently due to the carbon monoxide content of insufficiently combusted gas. In some cases the detected relatively low levels of COHb in blood indicate that in addition to the carbon monoxide poisoning the suffocation was also caused by lack of oxygen. The authors refer to the possibility of methane demonstration in blood, indicating the exposure of persons to the environment containing the earth gas.

Animals↗
PubMed1984

Long-term observation of retinal electrical activity in dialyzed and renal transplantation patients.

The electroretinographic (ERG) intensity-response function was evaluated in 90 patients subjected to regular dialysis treatment (RDT) and in 27 patients after renal transplantation. Using a logistic equation, three parameters for each set of ERG curves were computed: M, the retinal sensitivity; S, the slope; and A, the maximum attainable potential amplitude. A statistically significant decrease of the A and S values of both the b and a waves in the course of RDT was found. After approximately 6 years of RDT, the frequency of patients with pathological A and S values amounted to 94.6% (b wave) and 80.4% (a wave). On the other hand, renal transplantation was accompanied by a tendency to normalize the original pathological values of the ERG parameters. Changes of electrical retinal activity could contribute to the evaluation of the state of compensation in dialyzed patients.

Adult↗
PubMed1983

Pattern-reversal visual evoked potentials in patients with chronic renal insufficiency.

Visual evoked potentials (VEPs) were recorded from 88 patients with chronic renal insufficiency twice at a 6 month interval. In dialysed patients statistically significant decreases in amplitudes and prolongations of VEP peak latencies were found. Azotaemic non-dialysed patients showed related, but smaller, changes in their VEPs. In patients after kidney transplantation the VEP amplitudes were normal but peak latencies were prolonged. No systematic significant relationship between the VEPs and creatinine and urea levels in the blood could be shown.

Brain↗