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Biomedical subjects

J Erben

Publications and source records attributed to J Erben.

At least 37 records · Page 2Linked to original sources
PubMed1989

The plasma concentration and renal elimination of phenols in patients with chronic renal insufficiency.

The plasma concentration and renal elimination of phenols was studied in 32 individuals with various renal insufficiency (CRI) and in 30 healthy subjects. In patients with chronic renal insufficiency the increase in P phenols values correlated directly with Per and P urea. Daily urinary excretion of phenols in patients with CRI is only mildly decreased compared with that in healthy controls. Renal clearance (C phenols), 8.52 (+/- 2.69) ml/min on an average, decreases significantly in patients with CRI. While fraction excretion of phenols (FE phenols) was 9.53 (+/- 4.14) % on an average in healthy persons, patients with CRI displayed a significant increase. A significant linear correlation in the values of FE phenols and FEH2O and those of FE phenols and FE urea was documented. Our findings support the assumption that phenols are excreted by the kidney by a mechanism similar to that of urea excretion. Filtration of phenols in the glomeruli is followed, in healthy volunteers, by their significant reabsorption which is a flow-dependent process. In the residual nephrons of patients with CRI, the tubular reabsorption of phenols is decreased, a mechanism largely compensating the effect of decreased filtration of phenols on their total urinary excretion.

Adult↗
PubMed1989

[Determination and interpretation of carboxyhemoglobin in traces of biological material].

The author investigated the possibility of assessment of the carboxy haemoglobin level in blood stains and particles of tissues which contain at least minimal amounts of blood pigment. For the examination methods were modified which are used for similar estimations in blood. In the blood stains the decline of carboxy-haemoglobin was investigated in relation to some external influences. The author investigated also the ability of haemoglobin to react with carbon monoxide at different periods after the development of blood stains.

Blood Stains↗
PubMed1989

[Bone metabolism in patients after kidney transplantation].

The bone metabolism was evaluated in 20 patients after successful transplantation of the kidneys. In case of a functional graft within 22 months after transplantation of the kidneys complete regression of histological signs of secondary hyperparathyroidism was found, i.e. of fibrous osteodystrophy with a decline of the osteoclastic absorption and in 50% of the patients bone histology revealed osteomalacia. On the X-ray of the skeleton in 65% signs of osteoporosis were found, incl. 10% where the results were in discrepancy with the histological finding. The normal plasma calcium level before and after transplantation of the kidney was not affected. Other basic indicators of bone metabolism--phosphates, alkaline phosphatase, the bone isoenzyme of alkaline phosphatase and parathormone attained normal levels within 22 months after transplantation. Bone fluorides remain elevated also after 22 months following successful transplantation of the kidneys, although significantly less than before.

Bone and Bones↗
PubMed1989

[Early acute tubulointerstitial nephropathy in transplanted kidneys].

The authors investigated in a group of 124 patients the effect of acute tubular nephropathy and rejection on the period of functional persistence of transplanted kidneys. Transplants which developed tubulointerstitial nephropathy during the first two weeks after transplantation of the kidney had significantly lower cumulative indexes of survival for as long as the second year after transplantation. Grafts which were rejected during the first two weeks after transplantation had a significantly lower cumulative survival index only during the first and second year. The statistical significance was always tested in comparison with grafts where the postoperative course was uneventful. It is better to evaluate the functional prognosis of transplanted kidneys from the maximal achieved glomerular filtration after a load; it did not matter whether tubulointerstitial nephropathy or rejection was involved.

Acute Disease↗
PubMed1988

Ophthalmological lesions after long-term dialysis treatment.

In the sphere of dialysis treatment, the questions of adequacy of this form of treatment are receiving increasing attention. One of the criteria for the evaluation of this problem is no doubt the functional and anatomical state of the body. As the eye findings form an integral part of the entire clinical picture, the occurrence of pathological ophthalmologic lesions found after long term dialysis treatment (LTDT) can be used as a criterion of adequacy of the chosen treatment. Eye findings were evaluated in 12 patients with chronic renal insufficiency treated by haemodialysis for at least 10 years. On the external eye segment, most evident were degenerative changes of the pinguecula type, occurring in all patients. In all cases we also observed a massive disturbance of the retinal electrical activity (REA). In 58% of all examined patients we found a peculiar yellow-brownish pigmentation of the eye background. Greater or smaller alterations in the intra-ocular microcirculation in the chorioideal, retinal and papillary circulation regions were proven fluoroangiographically in all patients. In 5 eyes a marked disturbance of central vision was found as a result of pathological changes of the retinal centres or atrophy of the optic nerve. We may sum up that the haemodialysis treatment is yet not able to maintain all functions of the body at a satisfactory level.

Adult↗
PubMed1986

Can plasma concentration of middle molecules contribute to assessment of adequate dialysis treatment?

The aim of this study was to confirm or to reject whether plasma concentrations of individual fractions of middle molecular weight substances can become parameters for an adequate dialysis treatment and whether there exists a relation between that and some symptoms and signs in patients on regular dialysis. No changes in clinical condition, plasma concentration of middle molecules, or metabolic state after 5 years of short-time dialysis schedule were established. No difference was found in the plasma concentration of middle molecules after 6 months of continuous ambulatory peritoneal dialysis and in patients undergoing hemodialysis treatment. There was also no difference in glomerular filtration rate, blood urea concentration, dialysis index, and duration of regular dialysis treatment in patients with a middle molecular fraction 2 level lower and higher than 5.5 U/L. Elimination of fractions 2-4 and 6 by a 1-m2 Cuprophan coil dialyzer was similar to the elimination of creatinine. Only patients with acute respiratory infection had a fraction 2 higher than controls. Neither conventional parameters nor plasma concentrations of middle molecules can be indicators of an adequate dialysis. The well-being of patients and their metabolic state are the only criteria.

Adolescent↗