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Biomedical subjects

J E Simon

Publications and source records attributed to J E Simon.

At least 19 recordsLinked to original sources

Rules and regulations on the collection in Cameroon of biological materials for biological testing and drug discovery.

Regulations on the exploitation of Cameroon's rich biodiversity have tended to emphasize timber exploitation at the expense of non-timber uses. Materials for scientific research have been marginalized. However, in-service instructions usually provide practical guidelines such as specific charges that researchers must pay for the collection of samples. Even though the current law and text of application are silent on regulations addressing the scientific "prospecting' or exploitation of the forests, it is hoped that a particular text in conformity with the current regulations will provide more specific rules governing the collection, testing and exportation of biological materials for drug testing and discovery.

Animals↗

Use of magnetization transfer for improved contrast on gradient-echo MR images of the cervical spine.

PURPOSE: To evaluate whether magnetization transfer (MT) can improve image contrast on gradient-recalled echo (GRE) magnetic resonance (MR) images of the cervical spine. MATERIALS AND METHODS: Sagittal and axial two-dimensional conventional GRE and MT GRE images were obtained in 103 patients with degenerative disk disease or intrinsic cord lesions. The contrast-to-noise ratios (C/Ns) for the cervical spinal cord and cerebrospinal fluid (CSF) were compared for images obtained at various MT power level and section-select flip angle combinations. Axial three-dimensional GRE images were also obtained with application of MT and C/N evaluated in 10 additional patients. RESULTS: Tailored two-dimensional MT GRE images, obtained with a moderate MT power level and a section-select flip angle similar to the Ernst angle for CSF, provided an average of 2.2-2.4-fold improvement in spinal cord-CSF C/N than conventional GRE images (P < .001). CONCLUSION: The MT GRE images demonstrated superior delineation of disk herniations, foraminal stenosis, and intrinsic cord lesions over conventional GRE and T2-weighted spin-echo images in clinical cervical spine examinations.

Cervical Vertebrae↗

Thalamic amnesia: Korsakoff syndrome due to left thalamic infarction.

In order to support the concept that a lesion of the thalamus is sufficient to cause a Korsakoff syndrome, we are presenting 5 patients, all of whom developed the syndrome after sustaining a left (dominant) thalamic infarction. Two patients had pure thalamic strokes followed by a permanent Korsakoff syndrome. One of these patients was studied with neuropsychometric testing, as well as with a modern MRI scan. In 2 other patients, clinical and imaging data indicate that infarction was not limited to the thalamus. Another patient had bilateral thalamic infarcts but only a temporary Korsakoff syndrome. Neuropathological data are needed to elucidate the exact anatomical substrate of dominant thalamic Korsakoff syndrome.

Aged↗

Racemic epinephrine use in croup and disposition.

The purpose of this study was to determine the effectiveness of a protocol for the outpatient management of laryngotracheitis (croup) using racemic epinephrine and steroids. The authors retrospectively reviewed fifty consecutive charts of children with croup who were treated under this protocol in the Scottish Rite Children's Medical Center Emergency Department (Atlanta, GA) and discharged to home after 2 hours of observation. Forty-seven of the 50 children had stridor at rest and/or retracting at rest on presentation to the emergency department. Forty-seven of the 50 patients did not require further medical care within 48 hours. One patient required another emergency visit and additional treatment with racemic epinephrine. Two patients were lost to follow-up. This study suggests that selected children presenting with croup and significant distress may be effectively treated with racemic epinephrine and steroids, observed for at least 2 hours, and safely discharged home.

Aerosols↗

Computerized diagnostic referencing in pediatric emergency medicine.

A well-qualified and dedicated pediatrician in a mid-Atlantic state recently cared for a 4-year-old child with a fever and a truncal rash. On the second visit the child was lethargic but seemed to improve with oral hydration and fever control. Twenty hours later the child's rash became petechial and the child returned moribund and died shortly thereafter. Looking for an emergency differential diagnosis on a 4-year-old child with fever and a truncal rash would have been cumbersome using traditional reference materials. With PEM-DXP, however, a nurse or secretary could have produced for the physician in 60 seconds a list of 12 emergency diagnoses to be considered. Rocky Mountain spotted fever would have appeared on that list. (Ten percent of patients with Rocky Mountain spotted fever have a maculopapular rash, and in 10% of those children the rash begins on the trunk.) This list might have prompted this physician to ask about a tick bite. A positive response would have been obtained. Possibly the tragic outcome, for both the child and the physician, could have been avoided. Children with urgent complaints are frequently cared for by physicians who are busy, tired, sleep-deprived, and stressed in many other ways. These physicians often have not read last month's medical journals in their specialty or even last year's journals. Yet the parents' expectation, and rightly so, is that their pediatrician or emergency physician has at his or her command and is bringing to bear on the care of their child the vast knowledge base of medical science as it pertains to their child's condition. It is a totally unrealistic expectation. By computerizing reference materials in ways that allow for selectively searching for and compiling information pertinent to a given presentation, however, we can move a bit closer to meeting both the parents' expectations of us and our own expectations of ourselves.

Child↗

Tongue in cheek? Or in the bottle?

The case of an eight-year-old girl whose tongue became entrapped in a bottle is presented. Management options are discussed. Successful management utilizing a positive pressure technique is described and illustrated.

Child↗

Promethazine-induced dystonic reaction.

The case of a 15-year-old girl who experienced an acute dystonic reaction to promethazine therapy administered during an uncomplicated episode of acute gastroenteritis is reported. The pertinent literature is reviewed.

Acute Disease↗

Hydrocarbon poisonings.

Many different compounds are classified as petroleum distillates. Most ingestions can be managed by careful observation and respiratory support.

Animals↗

Reduction of contact factors in sickle cell disease.

Surface-mediated reactions of clotting were compared in 21 black children with homozygous sickle cell disease, 12 age-matched controls, and 15 adults. Both the coagulant and antigen titers of Hageman factor (factor XII) were decreased in asymptomatic patients compared with those in the control groups. These findings were associated with slight but significant reductions in the plasma titers of prekallikrein and high molecular weight kininogen. A further decrease from the initially low titers of these contact factors was observed during vaso-occlusive crises. Additionally, we observed a disparate relationship between Hageman factor coagulant activity and its antigen titers. These data provide evidence for reduction of the contact factors in patients with homozygous sickle cell disease.

Adolescent↗

Neuroleptic malignant syndrome.

Neuroleptic malignant syndrome (NMS) is a rare but potentially life-threatening complication of neuroleptic therapy. Its occurrence is not familiar to most emergency physicians. Early recognition and appropriate management of NMS may prevent significant morbidity and mortality.

Basal Ganglia Diseases↗

Prostaglandin inhibitors and the development of mung bean seedlings.

The effect of cortisol and prostaglandin inhibitors on the growth and development of germinating mung bean, Vigna radiata L. Wilzek, cv. Jumbo was investigated. Cortisol, indomethacin, and a mixture of cortisol with aspirin, or benoxaprofen significantly increased radicle length and the number of lateral roots as compared with non-treated controls. A mixture of cortisol and indomethacin significantly increased growth of hypocotyls.

Aspirin↗