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Biomedical subjects

J E Peters

Publications and source records attributed to J E Peters.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Aminopeptidases in the serum and urine of patients with hyperthyroidism].

In patients with hyperthyroidism the serum activities of the leucine aminopeptidase (LAP) and the alanine aminopeptidase (AAP) as well as the alanine aminopeptidase excretion in the urine were determined. A significantly increased activity of the leucine aminopeptidase in the serum and an increased excretion of alanine aminopeptidase in the urine were found. The AAP in the serum did not show a significant increase of activity. On account of the changes in the serum and in the urine before and during therapy a low-grade participation of the hepatobiliary and renal systems which are clinically not uppermost is to be assumed. Increased excretion of AAP and hyperthyroidism coincide nearly without exception in out patients. Correlation-statistical investigations make it probable to regard the increased excretion of AAP in the urine as an indirect parameter of the peripheral metabolism in hyperthyroidism.

Adult↗
PubMed1976

[Studies on the specificity of alanine aminopeptidase and its variants in the serum in hepatobiliary diseases].

After examinations on a mixed number of patients (236 patients) the increases of the activities of the alanine aminopeptidase in the serum with relatively high certainty may be traced back to diseases of the liver and of the bile ducts. The hepatobiliary specifity is disturbed only by generalised dermatological diseases, especially eczemas. Changes in the electrophoretic pattern of the serum alanine aminopeptidase are also relatively specific for diseases or lesions of the hepatobiliary system. In 11 of the 12 anomalous zymograms of the alanine aminopeptidase observed among 236 patients the aimed search resulted in an alteration of the hepatobiliary system.

Alkaline Phosphatase↗
PubMed1975

[The effect of therapeutic gentamycin doses on the enzyme secretion in urine].

8 patients with chronic pyelonephritis were given gentamycin intramuscularly injected in individual dosage during 8-10 days. Here the behaviour of the excretion of protein, alanine aminopeptidase alkaline phosphatase, alpha-glucosidase, gamma-glutamyl transpeptidase and lysozyme with the urine was tested. With the exception of the lysozymuria, which increased only in patients with chronic renal insufficiency, regularly a hyperenzymuria developed. Most distinctly the excretion of the alanine aminopeptidase increased. After initial decrease the excretion of total protein transiently increased after completion of the gentamycin therapy. All the deviations were reversible. From the increased excretion of enzymes may not be concluded to a nephrotoxicity of gentamycin.

Alkaline Phosphatase↗
PubMed1975

[Enzymes in urine following administration of hypertonic solutions].

3 patients with chronic nephropathies were given 20 ml of a diatrizoate-X-ray contrast medium, 500 ml of a 10% mannitol solution and 500 ml of a 10% dextran solution intravenously, and the behaviour of the excretion of protein, alanine aminopeptidase, beta-glucuronidase, aryl sulphatase A and lysozyme with the urine was tested. After application of these substances a transient increase of the excretion of alanine aminopeptidase, aryl sulphatase A and protein takes place. Conspicuous is the temporary decrease of the beta-glucuronidase activity in the urine after application of these hypertonic solutions. As a common cause of these changes alterations of the tubular cell in the sense of an osmotic nephropathy are to be assumed.

Aminopeptidases↗
PubMed1975

[Aminopeptidases in the serum following myocardial infarct].

In 19 patients wiht myocardial infarction during 7 weeks after the onset of the infarction the serum activities of the leucine aminopeptidase (LAP) and of the alanine aminopeptidase (AAP) were determined. Here an increase of the LAP-values with a maximum in the 1st week was found. Apparantly a hypoxic lesion of the hepatocytes is to be regarded as cause for this. In patients with shock symptomatology as well as with heart decompensation the AAP-activities were on the average higher than in the cases with myocardial infarction without these alterations during the whole period of observation. In all myocardial infarctions the AAP-zymograms showed an additional anodic AAP-fraction as it was observed in previous investigations in cholestasis.

Aminopeptidases↗
PubMed1975

A special neurological examination of children with learning disabilities.

Children with "minimal brain dysfunction" and learning disabilities were found to have significantly more minor neurological signs than control children. Many of these signs become less obvious or disappear by the age of 11 years; therefore older cases are more similar to controls, whereas younger cases show lags or deficits at the highest levels of central nervous system functioning-language, fine motor co-ordination and cross-modality integrations.

Age Factors↗