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Biomedical subjects

J E Peters

Publications and source records attributed to J E Peters.

At least 37 records · Page 2Linked to original sources
PubMed1986

Intellectual, behavioral, and linguistic characteristics of three children with 18p- syndrome.

Developmental characteristics of three girls with 18p- syndrome are described, with detailed history and results of psychological and speech/language evaluations completed at various ages. Results suggest that some children with 18p- syndrome have average abilities in selected areas, despite previous reports that these children have mild to severe mental retardation. Two of the three girls had more severe deficits in linguistic, as opposed to nonlinguistic, abilities. All had similar difficulties with speech articulation. It is suggested that children with speech/language delays who have physical features associated with this syndrome have chromosome analysis performed. It is also recommended that children identified as having 18p- syndrome be referred for comprehensive developmental assessments and remedial special education programming before a specific prognosis is determined.

Articulation Disorders↗
PubMed1986

Expandable intraluminal vascular graft: a feasibility study.

An expandable intraluminal graft mounted coaxially over an angioplasty balloon catheter was used in dog arteries. The graft, a wire mesh tube that has the ability to retain its expanded shape, opposes elastic recoil of the arterial wall after maximum balloon inflation. Eighteen grafts were placed in the abdominal aorta and iliac femoral, renal, superior mesenteric, and carotid arteries of eight dogs through femoral or carotid arteriotomies. Two grafts were placed in areas of artificially induced stenosis, completely restoring the lumen. Overall patency rate at 35 weeks was 77%. Histopathologic examination of patent grafts showed complete endothelialization at 3 weeks. The smaller caliber grafts and those that had outflow obstruction showed significant degrees of intimal hyperplasia.

Angiography↗
PubMed1985

The normal mucosal surface pattern of the duodenal bulb: radiologic-histologic correlation.

Similar to the stomach and colon, the duodenum also demonstrates a fine mucosal relief pattern on double-contrast radiographic examination. Two patterns may be identified--fine reticular and "small dot." In order to investigate the origin of these patterns, duodenal bulb specimens were obtained at autopsy, and macroscopic and microscopic features were correlated with radiographic patterns. Findings indicate that the surface patterns identified radiographically on cadaveric specimens and in live patient subjects are due to villi and the collections of barium within the intervening sulci. Knowledge of this normal pattern will prevent misdiagnoses, especially when inflammatory disease of the duodenum is being considered.

Duodenum↗
PubMed1983

Pruritic dermatitis in asthmatic basenji-greyhound dogs: a model for human atopic dermatitis.

A recurrent, nonseasonal pruritic dermatitis manifested as lichenified plaques and as inflammatory nodules and papules in each of fourteen basenji-greyhound (B-G) crossbreed dogs, all of which demonstrated both nonspecific and Ascaris-specific airway hyperreactivity, with changes in pulmonary mechanics of the same order as those seen in symptomatic human asthma. Other features analogous to human atopic disease included blunted cyclic adenosine monophosphate (cAMP) responsiveness to beta adrenergic agents and in vivo release of histamine and slow-reacting substance of anaphylaxis in response to antigen aerosol challenge. The dermatitis appears to be a manifestation of the atopic state in these dogs and may provide an animal model for the study of human atopic dermatitis.

Animals↗
PubMed1983

Pulmonary uptake of mannitol as an index of changes in lung epithelial permeability.

To develop a simple, inexpensive, and nontoxic test for changes in bronchial permeability we have employed a specific gas chromatographic assay to measure the uptake of mannitol from the lung after administration of an intratracheal aqueous bolus (8 ml of 5% solution). We have tested the ability of our method to detect the known increase in lung epithelial permeability elicited by challenge of previously sensitized animals with aerosols of Ascaris suum antigen. In Ascaris-sensitive Basenji-Greyhound dogs, antigen challenge significantly increased the rate of appearance and peak plasma level of mannitol after administration of the intratracheal bolus. Peak plasma mannitol levels averaged 25 +/- 3 (SE) micrograms/ml in dogs challenged with Ascaris antigen aerosols, and 14 +/- 2 micrograms/ml in the same animals in separate control experiments employing saline aerosols. The method presented could be readily applied to animal and human studies as a simple, inexpensive, and nontoxic indicator of lung epithelial permeability.

Aerosols↗
PubMed1982

Differential effect of chronic ethanol administration on rates of protein synthesis on free and membrane-bound polysomes in vivo in rat liver during dependence development.

Administration of ethanol thrice daily to rats in amounts sufficient to induce a high degree of physical dependence resulted in a 20% decrease in the rate of protein synthesis on liver membrane-bound polysomes in vivo after 3 days of treatment without affecting the rate on free polysomes. The inhibition was attributable to a decrease in the rate of polypeptide elongation as evidence by comparable decreases in nascent chain synthesis and completed protein release without any change in leucine uptake by liver. Chronic ethanol treatment did not affect the quantity or distribution of free and membrane-bound polysomes, the DNA concentration, or the weight of liver. The inhibition of protein synthesis on membrane-bound polysomes cannot, therefore, be readily ascribed to ethanol-induced nutritional deficiencies or to some nonspecific toxic effect of ethanol.

Alcoholism↗
PubMed1982

Changes in in vivo rates of protein synthesis on free and membrane-bound polysomes in rat brain during the development of physical dependence on ethanol and after the withdrawal of ethanol.

Administration of ethanol and nutrients to rats thrice daily by gavage for 3 days produced a linear increase in physical dependence during the first 3 days and a 2% increase in body weight. Rates of protein synthesis on free and membrane-bound polysomes in whole brain and in 7 brain regions, comprising the entire brain, were measured in vivo under pool expansion conditions with [3H]leucine at intervals during the development and decay of ethanol dependence. During dependence development there was a progressive decrease in the rate of protein synthesis on free polysomes, but this change was not significant (P less than 0.05) until the third day, and a decrease in the rate on membrane-bound polysomes after 3 days. The inhibition of protein synthesis is attributable to a decreased rate of polypeptide elongation. There was no change in brain weight, DNA content, ribosome content, ribosome distribution of mRNA pool size. There was, however, a decrease in leucine uptake after 3 days. In an attempt to distinguish between the acute effects of ethanol on regional rates of protein synthesis and those changes associated with dependence development, rates were measured 1.5 h after administering a 5 g/kg dose of ethanol to both control and dependent rats. Rates on free polysomes in the hippocampus-amygdala and thalamus-hypothalamus and on membrane-bound polysomes in the cerebellum and hippocampus-amygdala of dependent rats were reduced; however, there was a general reduction in the rates in control rats that may have obscured reductions in other regions from dependent rats. During early withdrawal, 12 h after the last dose of ethanol, there was an increase in the rate of free polysomes in the pons-medulla and striatum-septum and on membrane-bound polysomes in the hippocampus-amygdala, and a decrease in the rate on free polysomes in the cortex and thalamus-hypothalamus and on membrane-bound polysomes in the cortex. After 24 h, there was an increase in the rate on free polysomes in all regions (cerebellum, cortex, mesencephalon, striatum-septum and thalamus-hypothalamus) except the hippocampus-amygdala and pons-medulla and an increase in the rate on membrane-bound polysomes in all regions (cortex, hippocampus-amygdala, mesencephalon, pons-medulla and striatum-septum) except the cerebellum and thalamus-hypothalamus. The possible relationship of these changes to the homeostat hypothesis of ethanol dependence is discussed.

Alcoholism↗
PubMed1982

The Basenji-Greyhound dog model of asthma: leukocyte histamine release, serum IgE, and airway response to inhaled antigen.

To understand the immunologic mechanisms underlying the variation in airway response to inhaled Ascaris antigen (AA) in Basenji-Greyhound (BG) dogs having hyperreactive airways, we examined the relationship between leukocyte histamine release, Ascaris-specific serum IgE, changes in pulmonary resistance (RL), and decreases in dynamic compliance (Cdyn). All Ascaris-sensitive BG dogs showing airway responses to AA aerosol challenge exhibited an antigen dose-dependent release of leukocyte histamine, with total leukocyte histamine ranging from 68 to 123 ng/10(7) cells. Airway response to inhaled antigen more closely correlated with antigen dose releasing 50% total leukocyte histamine (RL, r = 0.94); Cdyn, r = 0.82), than with circulating levels of antigen-specific IgE (RL, r = 0.68; Cdyn, r = 0.69). We conclude that the airway response of sensitized BG dogs to AA inhalations is more dependent on factors affecting mediator release from pulmonary sources than circulating specific reaginic antibody.

Airway Resistance↗
PubMed1981

Basenji-greyhound dog model of asthma: pulmonary responses after beta-adrenergic blockade.

To understand the mechanism underlying bronchial hyperreactivity in the Basenji-Greyhound (BG) dog, the effects of propranolol (2 mg/kg) and hexamethonium (5 mg/kg) on base-line pulmonary mechanics and on the bronchial response to aerosol challenges of citric acid and methacholine were studied in five BG dogs. Both propranolol and hexamethonium increased base-line pulmonary resistance (RL) from 0.69 +/- 0.05 (means +/- SE) cmH2O.l-1.s to 1.67 +/- 0.10 (P less than 0.05) and 2.22 +/- 0.45 cmH2O.1-1.s (P less than 0.05) and decreased dynamic compliance (Cdyn) from 190 +/- 10 ml/cmH2O to 154 +/- 9 (P less than 0.05) and 140 +/- 9 (P less than 0.05) ml/cmH2O, respectively. Both propranolol and hexamethonium potentiated the pulmonary response to 10% citric acid given for 5 min (P less than 0.05). RL postchallenge was 4.4 +/- 0.23, 8.1 +/- 0.81, and 7.8 +/- 0.31 cmH2O.l-1.s, and Cdyn was 78 +/- 5, 58 +/- 6, and 51 +/- 3 ml/cmH2O in untreated, propranolol-pretreated, and hexamethonium-pretreated animals. In untreated BG dogs, methacholine (0.075 mg/ml) increased RL from 0.94 +/- 0.25 to 2.2 +/- 0.21 cmH2O.l-1.s (234%) and decreased Cdyn from 223 +/- 39 to 141 +/- 14 ml/cmH2O (63%). In the same animals pretreated with propranolol, methacholine (0.075 mg/ml) increased RL from 1.9 +/- 0.66 to 4.8 +/- 1.37 cmH2O.l-1.s (253%) and decreased Cdyn from 144 +/- 35 to 81 +/- 15 ml/cmH2O (56%). We conclude that propranolol produces airway constriction in BG dogs, as in asthmatic humans and that the effects of propranolol on airways in BG dogs are not due to parasympathetic or alpha-adrenergic predominance.

Adrenergic beta-Antagonists↗
PubMed1978

Immunochemical characterization of Lymantri dispar NPV hemagglutinin: protein-carbohydrate interaction.

The agglutination of chicken erythrocytes by Lymantria dispar nuclear polyhedrosis virus polyhedrin has been shown to provide specific virus identification. Selected mono- and oligosaccharides, present in blood group substances, were assayed by the Land-steiner hapten inhibition technique for specific inhibition of polyhedrin hemagglutination. N-acetylgalactosamine and N-acetylglucosamine inhibit to the greatest extent; galactosamine, glucosamine and fucose to a lesser extent. The hapten inhibition data suggest that a monosaccharide possessing an equatorial 2-acetamido group interacts most avidly with the polyhedrin-combining site. Bergold demonstrated that the polyhedrin dissociates into six subunits at a pH greater than 10.0. Diafiltration equilibrium and Scatchard analysis indicate that N-acetylgalactosamine binds most avidly to the polyhedrin (Kd = 1.7 X 10(-6)) which contains six available sites, suggesting that one hemagglutination site resides on each subunit. Since virions derived in vivo and polyhedrin are serologically cross-reactive, this protein-carbohydrate interaction may play a role in host infectivity by providing a receptor site for virus attachment to target cells.

Acetylgalactosamine↗
PubMed1977

[Laboratory diagnosis of liver and biliary tract disease].

Of a greater number of biochemical tests in hepatobiliary diseases by means of methematico-statistical methods (calculation of specificity and sensitiveness, variance analysis, discrimination analysis with following discrimination experiments) the parameters should be established which in a step programme with multivariate observation and non-discriminated approach give the best possible information. The recognition of patients with liver diseases (preliminary diagnostics) is at nearly 94% possible with a scale comprising GOT, AAP, some relevant clinical data (touch findings, jaundice, hepatic skin signs) and the hepatitis B-antigen. In non-discriminated approach according to our findings the following scale should not be trangressed: GPT, GOT (compare preliminary diagnostics), LAP, AP, AAP (compare preliminary diagnostics), cholesterol, TTT, bilirubin, beta-GC. As to aimed questionings the bromsulphalein test belongs to the enlarged basic scale.

Biliary Tract Diseases↗