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Biomedical subjects

J E Parisi

Publications and source records attributed to J E Parisi.

119 records · Page 7Linked to original sources
PubMed1985

Brain metabolism as measured with positron emission tomography: serial assessment in a patient with familial Alzheimer's disease.

This paper presents, for the first time, repeated assessments of cerebral metabolism and neuropsychological competence in early Alzheimer's disease. Regional cerebral metabolic rates for glucose were measured with positron emission tomography and 18F-fluoro-2-deoxy-D-glucose on three occasions at 8-month intervals, in a 57-year-old man with Alzheimer's disease of 2 1/2 years' duration and with a family history of neuropathologically confirmed Alzheimer's disease. Data were compared with mean cerebral metabolic rates from 12 healthy men. No differences in regional cerebral metabolic rates for glucose were found on the initial patient scan, whereas metabolism on the second and third scans was reduced significantly in the parietal lobes and bilaterally in some parietal lobe regions. Memory loss was demonstrable at the first scan, but then and at later scans, other aspects of cognitive performance remained within normal limits (Wechsler Adult Intelligence Scale, Boston Naming Test, Two-dimensional Block Construction). The results show that memory loss can precede a measurable reduction of cerebral metabolism in early Alzheimer's disease, but that later reductions in parietal lobe metabolism may not be accompanied by additional measurable neuropsychological deficits.

Aged↗
PubMed1984

Focal motor seizures complicating carotid endarterectomy.

We studied four patients with focal motor seizures complicating carotid endarterectomy and compared them with 14 other cases reported previously. Seventeen of the 18 patients had high-grade carotid stenoses. A severe unilateral headache usually preceded seizure activity, which was followed by prolonged Todd's paralysis. Eight patients had histories of ipsilateral stroke. There was no association with perioperative hypertension. Two patients who were receiving heparin sodium had intracerebral hemorrhages that caused one of the two postoperative deaths. The patency of all endarterectomized carotid arteries was recorded by arteriography or noninvasive studies. These data suggest that patients who have severe unilateral headaches following ipsilateral carotid endarterectomy for high-grade stenoses are at risk for focal motor seizures. The roles of antithrombotic agents and anti-seizure medication in this setting are unclear.

Arterial Occlusive Diseases↗
PubMed1984

Creutzfeldt-Jakob disease: a case of 16 years' duration.

A 46-year-old man with Creutzfeldt-Jakob disease confirmed postmortem had a 16-year course of very slowly progressing incoordination and mental deterioration, suggesting Alzheimer's disease. The disease course transformed abruptly into a 7-week terminal phase of florid Creutzfeldt-Jakob disease. Dementing illnesses of unknown cause were present in the patient's paternal lineage.

Brain↗
PubMed1983

Prenatal symmetrical thalamic degeneration with flexion spasticity at birth.

The unusual occurrence of spasticity at birth with symmetrical thalamic damage was found in a male infant delivered at 36 weeks' gestation following an episode of traumatically induced premature labor at 32 weeks. The infant was found to be spastic in flexion with increased stretch reflexes, depressed primitive reflexes, and moderate flexion contractures. Computerized tomographic scans showed bilateral nonenhancing thalamic densities. Neuropathologically, the lateral thalamic nuclei and the red nucleus showed neuron loss, astrocytosis, and, as confirmed by electron microprobe analysis, calcified neurons. The striatum was uninvolved. These findings closely resemble those reported as "symmetrical thalamic degeneration in infancy" and are strongly reminiscent of the pattern of thalamic involvement frequently seen in status marmoratus. It would appear that there is a period during perinatal life in which the lateral thalamus can be rendered vulnerable to hypoxic-ischemic injury, and that the thirty-second week of gestation must be included within this period.

Brain Ischemia↗
PubMed1982

Cerebral capillary telangiectasis in an infant. Coincidental Association with hypsarrhythmia.

We studied a case of cerebral capillary telangiectasis in infancy. The patient, who had received treatment with intramuscular corticotropin for hypsarrhythmia, suffered disseminated intravascular coagulation and died on the 66th day of life. Neuropathological examination disclosed the presence of two fresh hemorrhages of moderate size within the cerebral hemispheres, one of which seemed to have originated from a capillary telangiectasis within the left frontoorbital white matter.

Brain↗
PubMed1982

Rheumatoid nodule formation within the choroid plexus. Report of a second case.

A woman with active systemic rheumatoid disease had striking neuropsychiatric manifestations; a rheumatoid nodule within the choroid plexus was the sole neuropathological finding. Although we found only one other report of findings of this type in rheumatoid disease, we suspect that this phenomenon may not be as rare as originally believed, and that it may represent another mechanism by which behavioral changes develop in this disorder.

Aged↗
PubMed1981

Familial dementia of adult onset with pathological findings of a 'non-specific' nature.

A family is described in which 4 of 10 siblings developed a dementing illness that culminated in death within five to six years of onset. The pathological findings in 3 members were strikingly similar, and consisted of widespread nerve cell loss and astrocytosis within the cerebral cortex, status spongiosus within the outer cortical layers and, in 2, nerve cell loss and astrocytosis within the dorsomedial nucleus of the thalamus. It is concluded that the disorder described in this report does not conform precisely to any of the currently recognized categories of familial dementing disease.

Aged↗
PubMed1981

Pallidonigral pigmentation and spheroid formation with multiple striatal lacunar infarcts.

A 72-year-old hypertensive man had focal seizures and mild memory loss. At autopsy, there were many lacunar infarcts, particularly in the neostriatum. Rust-brown discoloration and spheroid formation within the globus pallidus and pars reticulata of the substantia nigra resembled Hallervorden-Spatz disease, in which more detailed analysis of the striatum may be worthwhile.

Aged↗
PubMedDate not supplied

A beta-associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo).

In this study of an aged wolverine (Gulo gulo), we document neuropathologic lesions (cerebral amyloid angiopathy (CAA), neuritic plaques (NPs), neurofibrillary tangles (NFTs), and granulovacuolar degeneration strikingly similar to those present in aging and Alzheimer's disease (AD), with the additional finding of concurrent cerebral hemorrhage. A beta immunoreactive cerebral amyloid angiopathy and senile plaques (neuritic and diffuse) were present throughout the cerebral cortex and hippocampus. Ubiquitin immunoreactivity was noted in peripheral portions of some of the plaques. Argyrophilic intracellular neurofibrillary tangles containing abnormally phosphorylated (Ser 202) tau protein were present within cortical and hippocampal neurons. The wolverine should be added to the list of nonhuman species (dogs, nonhuman primates, polar bears) with amyloid deposits similar to those in aged humans and in humans with AD. The aged wolverine appears to be distinct from other nonhuman species in possessing plaques and NFTs, as well as other histologic cerebral lesions frequently associated with AD.

Aging↗
PubMedDate not supplied

Cerebral venous angiomas: MR findings.

Seven patients with suspected cerebral venous angioma studied by either CT or angiography were imaged with magnetic resonance. Six of seven cases demonstrated a stellate appearance on contrast enhanced CT. In two patients this finding was verified by angiography. Flow void was identified on both T1- and T2-weighted pulse sequences. In one patient a field echo sequence demonstrated high intensity signal within the venous angioma. Magnetic resonance proved superior to CT in the identification of these lesions. A stellate configuration with an emanating transcortical vein and centrifugal drainage (transcortical venous flow) from the angioma into a sinus was present in all cases. Centripetal drainage via thalamostriate and internal cerebral veins was not seen. There was no evidence of mass effect, scar, or hemorrhage. Four of the angiomas were located in a frontal lobe and three in a cerebellar hemisphere. This distribution of the lesions is similar to that reported in the literature in which the frontal lobe is the most common location followed by the cerebellar hemisphere. An embryological explanation is cited and supported by a review of the literature.

Adolescent↗