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Biomedical subjects

J E Fulton

Publications and source records attributed to J E Fulton.

At least 73 records · Page 4Linked to original sources
PubMed1990

The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing.

Full-face dermabrasion provided an ideal opportunity to document the effects of dressings on wound healing management. Following the procedure, the abraded face was divided in half. One side was treated with the standard polyethylene oxide gel wound dressings. The other side was treated with a polyethylene oxide gel dressing saturated with stabilized aloe vera. The polyethylene oxide dressing provided an excellent matrix for the release of aloe vera gel during the initial 5 days of wound healing. By 24-48 hours there was dramatic vasoconstriction and accompanying reduction in edema on the aloe-treated side. By the third to fourth day there was less exudate and crusting at the aloe site, and by the fifth to sixth day the reepithelialization at the aloe site was complete. Overall, wound healing was approximately 72 hours faster at the aloe site. This acceleration in wound healing is important to reduce bacterial contamination, subsequent keloid formation, and/or pigmentary changes. The exact mechanism of acceleration of wound healing by aloe vera is unknown.

Aloe↗
PubMed1988

Role of anxiety and anger in acne patients: a relationship with the severity of the disorder.

Studies investigating the possible role of personality and emotional factors in acne patients have yielded inconsistent and sometimes contradictory results. In the present study acne patients self-rated the severity of their conditions as mild, moderate, or severe and were compared to a control group on several personality variables. These self-ratings were compared to the objective ratings made by their dermatologists. Acne patients who self-rated their conditions as severe were found to experience significantly higher levels of trait anxiety than patients with mild and moderate conditions and control subjects; patients with severe and moderate conditions showed a higher state of anxiety than control subjects. Acne patients rated as severe by their dermatologists showed higher states of anxiety, "anger-in," and "anger-out" than the others. No other significant differences in terms of severity emerged, supporting the view that acne patients are not markedly neurotic. The results suggest that anxiety and anger are significant factors for severe acne patients and that future research should include severity ratings from both patients and physicians in the research design.

Acne Vulgaris↗
PubMed1987

Anatomical defects associated with a feathering mutant (Ottawa naked) in domestic fowl.

An autosomal recessive mutation (Ottawa naked, nk) that causes abnormal feathering, fusion of the third and fourth toes, and low viability has been reported previously in the chicken. In the present study mutant individuals were examined from three different stocks: the original one in which the mutant was found and two outbred F2 stocks. Defects of the tail region were observed in all mutants from the original stock (20/20) and in 64% (16/25) of the mutants produced from the outcrossed stocks. The severity of the defects ranged from mild distortion and scoliosis of the coccygeal vertebrae to absence of all vertebrae from the lumbosacral level caudad. Forty percent (16/40) of the mutants from the original stock lacked caudal portions of the kidneys to varying degrees. Edematous areas were observed in 22% (15/67) of the embryos examined at 14 days of incubation. Other defects observed in the mutant embryos but not studied in detail are abnormal patterning or absence of scales, absence of the caudal spinal cord in embryos with severe rumplessness, and failure of the three metatarsal bones to fuse into a single element. Since all structures affected in the mutants differentiate primarily from or may be dependent upon the mesoderm, it is suggested that the site of gene action lies within this germ layer. A decrease was observed in both incidence and severity of the various defects following outcrossing, which suggests the presence of modifiers that influence the expression of the trait.

Animals↗
PubMed1987

Dermabrasion-Loo-punch-excision technique for the treatment of acne-induced osteoma cutis.

Three patients with chronic osteoma cutis secondary to acne vulgaris were treated with the dermabrasion-Loo-punch-excision technique. Under regional nerve block with lidocaine-bipuvacaine (50:50) a uniform dermabrasion was performed across the entire face, including the hairline and 1 cm below the jawline. This exposed the foci of osteoma cutis. Then the appropriate sized Loo punch (usually the 2.0- or the 2.5-mm punch) was used to excise the bluish-gray miliary lesions. The majority of the foci were removed in one operation. Following excision, the lesions were closed with 7-0 prolene suture. To prevent crust formation postoperatively, Aloe-vera-soaked polyethylene oxide gel dressings (Vigilon) were changed twice daily following an ice water compress. Sutures were removed rapidly in 5 to 7 days to prevent the appearance of suture lines. Although one patient required an additional procedure, the cosmetic results were excellent. Only a few small residual blue "dot" lesions remained in these three cases.

Acne Vulgaris↗
PubMed1987

Modern dermabrasion techniques: a personal appraisal.

Improvements in dermabrasion techniques have upgraded the therapeutic results for the removal of acne scars, sun-damaged skin, and related skin lesions in selected patients. To help patient compliance and therapeutic response, and to avoid pitfalls, extensive step-by-step predermabrasion evaluation and patient selection procedures are helpful. Standard checklists, operative techniques, and patient follow-up procedures have improved the results. Currently, the optimal dermabrasion procedure consists not only of an extensive facial planing, but the use of Loo punch or scalpel excision and the suturing of large cysts and scars during the procedure and the filling of valley-like depressions with liquid collagen or silicone after the procedure. These methods of extensive standard procedures and protocols, rigid patient selection, and pre-, during, and postdermabrasion follow-ups are presented so medical staffs can avoid common pitfalls.

Acne Vulgaris↗
PubMed1984

Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear.

Cosmetics continue to be used by acne-prone individuals. Often as more acne develops, more cosmetics are applied. In order to protect against this natural tendency, physicians should provide more patient information on the currently available products and ingredients. This presentation is designed to help in that effort. The data presented were gleaned from the rabbit ear assay, which is not an ideal animal model but is the best we have. If an ingredient is negative in the rabbit ear assay, we feel it is safe on the acne-prone skin. A strong, positive ingredient or cosmetic should be avoided. Ingredient offenders include isopropyl myristate and its analogs, such as isopropyl palmitate, isopropyl isostearate, butyl stearate, isostearyl neopentanoate, myristyl myristate, decyl oleate, octyl stearate, octyl palmitate or isocetyl stearate, and new introductions by the cosmetic industry, such as propylene glycol-2 (PPG-2) myristyl propionate. Lanolins continue to be a problem, especially derivatives such as acetylated or ethoxylated lanolins. Our most troublesome recent finding is the comedogenic potential of the D & C Red dyes. They are universally used in the cosmetic industry, especially in blushers. This may explain the predominance of cosmetic acne in the cheekbone area. All of these D & C Red dyes tested to date, the xanthenes, monoazoanilines, fluorans, and indigoids, are comedogenic. Actually, this is not surprising as they are coal tar derivatives. The natural red pigment, carmine, is noncomedogenic and can serve as a substitute for D & C dyes in blushers. Many finished products are comedogenic. Most troublesome to the dermatologists are the therapeutic tools that we use, such as Liquimat, Retin-A cream, Hytone, Staticin, Sulfoxl, Desquam-X, and Persadox HP cream. These should be reformulated. We have been unable to confirm that precipitated sulfur (U.S.P.) is a potent comedogen in the rabbit ear assay. Clinically, we still find sulfur quite effective as an adjuvant to the benzoyl peroxide therapy for the treatment of acne vulgaris. We would suggest that the bias against sulfur be reconsidered.

Acne Vulgaris↗
PubMed1983

Treatment of acne vulgaris by biofeedback relaxation and cognitive imagery.

A multielement intervention involving biofeedback-assisted relaxation and cognitive imagery treatment of acne vulgaris was investigated in this study with 30 patients receiving medical dermatological treatment. Patients were matched on age, sex, and pre-treatment acne severity and randomly assigned to groups. Treatment consisted of 12 sessions over six weeks and resulted in a significant reduction in acne severity as compared to the attention-comparison and medical control groups. Treatment group patients continuing home practice until follow-up maintained their gains, whereas those who discontinued failed to maintain gains.

Acne Vulgaris↗
PubMed1982

"Porcupine": a feather structure mutation in Japanese quail.

A type of feather structure abnormality in Japanese quail resulting from the failure of barbs to uncoil was found to be controlled by a single autosomal recessive gene, pc (porcupine). The mutation was first identified in two birds from a population homozygous for white plumage color. Porcupine quail have poor egg production, lower fertility, and higher embryonic and chick mortality compared to wildtype or heterozygotes.

Animals↗
PubMed1982

Short barb: a feather structure mutation in Japanese quail.

A type of feather structure abnormality in Japanese quail resulting in shortened barbs on contour feathers was found to be controlled by a single autosomal recessive gene, sh (short barb). The mutation was first identified in a full-sib family from the University of British Columbia wild type line. Unlike other feather structure mutations in Japanese quail reported previously in literature, the short barb mutation is not associated with poor reproduction.

Animals↗
PubMed1978

Dermabrasion by diamond fraises revolving at 85,000 revolutions per minute.

Use of a high-speed, air-driven turbo-grinder equipped with diamond fraises that revolve at 85,000 revolutions per minute has improved results in dermabrasions on the face by, it is estimated, 50%. Dermabrasions have been done with this turbo-grinder for scarring from acne, actinic damage, syringomata, lesions of adenoma sebaceum and some other facial conditions. The rapid evaporation, nonimflammability, nonnarcotic, and excellent freezing properties of Freon 12 eliminate the necessity for auxiliary cooling fans. It is thought too that the incidence of secondary infections and keloids have been decreased by use of an ointment of erythromycin (1%) topically during the healing period.

Acne Vulgaris↗
PubMed1976

Non-comedogenic cosmetics.

The need for a "comedogenic-free" cosmetic for acne patients led to this study using the only available mode, the rabbit. To facilitate the formulation of this benign cover-up, a range of cosmetics and ingredients was tested. Many cosmetics, fractions, and modifications of lanolins were comedogenic, as were emulsifiers such as butyl sterate, isopropyl myristate and sodium lauryl sulfate. From this data we incorporated non-comedogenic, into an acceptable cosmetic formulation for patients. The use of this formulation in susceptible acne-prone women reduced the rate of "acne cosmetica" in our clinic patients from 25% to less than 5%. We were unable to confirm a recent study suggesting that sulfur was a potent acnegen.

Acne Vulgaris↗
PubMed1975

Sebum: analysis by infrared spectroscopy. II. The suppression of fatty acids by systemically administered antibiotics.

Various tetracyclines and erythromycins have been used rather empirically for the systemic treatment of acne vulgaris for more than a decade. It has been impossible to accurately evaluate clinically the numerous derivatives and to compare their effectiveness with other antibiotics such as clindamycin. As a substitute for this approach, this present study ranks these antibiotics, when given orally, as to their effectivensss in suppressing the fatty acids in sebum in normal volunteers. As a group, the tetracyclines were more effective than the erythromycins in decreasing the fatty acids, but clindamycin was significantly more potent than either.

Acne Vulgaris↗
PubMed1975

Acne vulgaris.

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Acne Vulgaris↗
PubMed1975

Miconazole therapy for endemic fungal disease.

Miconazole nitrate (2.0%) cream was evaluated in the treatment of endemic dermatophytosis in an overcrowded prison. The active drug was compared in a random double-blind study with its control vehicle in the treatment of 99 inmates who had moderate to severe symptomatic disease. Tinea cruris and tinea pedis caused by Trichophyton rubrum predominated, although Trichophyton mentagrophytes and Candida albicans were also isolated and identified. Prompt clinical clearing occurred in 75.5% of those treated with miconazole versus 12.0% of those treated with the vehicle alone. Results of mycological examination closely paralleled and confirmed these clinical results.

Administration, Topical↗