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Biomedical subjects

J E Crowe

Publications and source records attributed to J E Crowe.

63 records · Page 4Linked to original sources
PubMed1977

Large vein of Galen aneurysms in the neonate. A constellation of diagnostic chest and neck radiologic findings.

A constellation of plain film findings which can assist in the diagnosis of large intracranial arteriovenous malformations in the newborn is presented. Alone, none of these findings is specific but in combination they become highly suggestive of the diagnosis. They consist of: 1. cardiomegaly with right chamber preponderance and superior mediastinal widening, 2. retrosternal fullness and posterior displacement of the trachea, and 3. retropharyngeal soft tissue thickening.

Cardiomegaly↗
PubMed1977

Acute bowing fractures of the forearm in children: a frequently missed injury.

Acute bowing of the bones of the forearm in children following trauma has only recently been recognized as a clinical and radiographic entity. This type of injury has been overlooked in the past because of lack of familiarity with the mechanical properties of curved tubular bones. Absence of a fracture line and the usual findings associated with a healing fracture on radiographs has contributed to the lack of recognition of this condition. The mechanism of injury, clinical and radiographic findings, clinical implications, and classification of these elusive childhood fractures are discussed on the basis of a study of 13 children.

Adolescent↗
PubMed1975

Cardiophrenic adenopathy in Hodgkin disease.

Hodgkin disease can involve diaphragmatic lymph nodes adjacent to the heart. When nodes at the cardiac apex are involved, the roentgenographic appearance simulates that of the normal pericardial fat pad. Though, to our knowledge, no cases have been reported in which this was the only intrathoracic manifestation of Hodgkin disease at the time the patient was first seen and the condition was diagnosed, it may be the only manifestation of relapse, as was true in the case presented.

Adolescent↗
PubMedDate not supplied

Immune responses of infants to infection with respiratory viruses and live attenuated respiratory virus candidate vaccines.

Respiratory viruses such as respiratory syncytial virus (RSV), the parainfluenza viruses (PIV), and the influenza viruses cause severe lower respiratory tract diseases in infants and children throughout the world. Experimental live attenuated vaccines for each of these viruses are being developed for intranasal administration in the first weeks or months of life. A variety of promising RSV, PIV-3, and influenza virus vaccine strains have been developed by classical biological methods, evaluated extensively in preclinical and clinical studies, and shown to be attenuated and genetically stable. The ongoing clinical evaluation of these vaccine candidates, coupled with recent major advances in the ability to develop genetically engineered viruses with specified mutations, may allow the rapid development of respiratory virus strains that possess ideal levels of replicative capacity and genetic stability in vivo. A major remaining obstacle to successful immunization of infants against respiratory virus associated disease may be the relatively poor immune response of very young infants to primary virus infection. This paper reviews the immune correlates of protection against disease caused by these viruses, immune responses of infants to naturally-acquired infection, and immune responses of infants to experimental infection with candidate vaccine viruses.

Child↗