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Biomedical subjects

J Dusek

Publications and source records attributed to J Dusek.

At least 109 records · Page 6Linked to original sources
PubMed1986

Significance of nucleo-cytoplasmic maturation asynchrony in multiple myeloma.

Bone marrow samples of 97 patients with multiple myeloma were examined ultrastructurally over a period of eight years, and the degree of nucleo-cytoplasmic maturation asynchrony (NCA) of myeloma plasmocytes was estimated according to the classification scale of Graham and Bernier. One half of the patients showed first degree, 40 percent second and 10 percent third degree of NCA. Clinical classification of the disease according to the staging system of Durie and Salmon and the quantitative staging system of Salmon and Wampler showed some relation to the degree of NCA. The degree of NCA was found to be related to the density of the bone marrow infiltration with myeloma plasmocytes but not to the response to chemotherapy. Some relation was seen to exist between the degree of NCA in myeloma plasmocytes at diagnosis and the prognosis of the disease. The role of electron microscopical analysis in MM diagnostics and its contribution to management of the disease are discussed.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

[Primary hemangioendothelioma of the bone marrow].

A case of malignant haemangioendothelioma in a 61-year-old female is described. The tumour infiltrated extensively medullary spaces in a number of bones without their destruction. Extraskeletal neoplastic foci were found in the intestine and in a lymph node, liver and especially spleen were involved more extensively. Several diagnostic features of the tumour are listed together with its position in some recent classification schemes.

Bone Marrow Diseases↗
PubMed1985

Ultrastructure of isoproterenol-induced myocardial damage in chick embryos.

Isoproterenol is known to cause severe myocardial lesions when given in toxic doses to adult homoiotherms. Previous studies on chick embryos revealed myocardial damage with scattered necroses in the outer layer of ventricular myocardium. The present ultrastructural study, performed on embryos 6 to 20 days old, has shown various types of cellular lesions; mainly cellular oedema, mitochondrial swelling, necroses of isolated cardiac muscle cells, fatty degeneration, accumulation of glycogen, and signs of increased proteosynthesis in the surviving muscle cells. Morphological features of the lesions differed from those which are known to be induced by isoproterenol in adult animals and seemed to depend on the stage of embryonic development.

Animals↗