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Biomedical subjects

J Dumont

Publications and source records attributed to J Dumont.

At least 91 records · Page 5Linked to original sources
PubMed1980

Acute myeloid leukemia following non-Hodgkin's lymphoma: danger of prolonged use of chlorambucil as maintenance therapy.

Four patients who developed acute myeloblastic leukemia during the treatment of a non-Hodgkin's lymphoma are described. In three cases the same sequence was observed: a favorable histological type of lymphoma, an apparently complete and lasting remission, a long period of tri-cytopenia, and finally acute myeloid leukemia. The fourth patient had a non-favourable histological type of lymphoma and developed acute myeloblastic leukemia during a relapse. The illustrations clearly show the distinction between lymphoid and myeloid disease in the four cases. A review of previously reported similar cases is summarized in two tables. Many patients received chemotherapy including alkylating agents (as did the four patients reported here). Most of them received chlorambucil, usually given over several years, at total doses ranging from 2 to 15 g. This treatment, frequently used as maintenance therapy in low-grade malignancy lymphoma, seems to be particularly dangerous.

Adult↗
PubMed1979

Hairy-cell leukaemia with polyarteritis nodosa.

In four patients a systemic vasculitis similar to polyarteritis nodosa developed within 2 years of the onset of hairy-cell leukaemia. Arteriographic studies in two patients revealed microaneurysms, and biopsy specimens in three patients revealed a vasculitis affecting medium-sized vessels. Blood neutrophilia and neutrophilic vascular infiltrate were absent. One patient had circulating immune complexes. Two patients responded to corticosteroids alone, one required cyclophosphamide as well as steroids, and one improved without chemotherapy. The association of vasculitis with hairy-cell leukaemia may provide insight into the pathogenesis of arteritis.

Adult↗
PubMed1979

[Comparative study of anti EBV antibodies in non-Hodgkin's lymphomams and angio-immunoblastic lymphadenopathies (author's transl)].

Antibody titers to Epstein-Barr virus (EBV)--related antigens (viral capsid antigen : VCA; early antigen : EA; and EBV associated nuclear antigen : EBNA) were determined in the sera of 86 patients and 150 matched control subjects. The patients belonged to four histological groups : diffuse and nodular non-hodgkin's lymphomas angio-immunoblastic lymphadenopathies and apparented syndroms. The incidence of antibodies to other herpes-viruses (cytomégalovirus, herpes simplex virus, and varicella zoster virus) was compared. There was a significantly higher incidence of anti VCA and anti EA titers in some patients, not associated with an increase in titres of antibodies to other herpes viruses.

Adolescent↗
PubMed1979

[Angioimmunoblastic lymphadenopathy: ultrastructural study of lymph nodes. Possible relationship with Epstein-Barr Virus (EBV) (author's transl)].

Angioimmunoblastic lymphadenopathy (AIL) has been clinically and histopathologically described by several authors since 1972, but only a few papers have analyzed the morphological aspects of the lymph nodes as observed by using electron microscopy. In the past three years, we happened to see in the Curie Institute two typical cases of AIL, both of whose clinical and immunological data are briefly reported in this paper. We describe some peculiar patterns observed on the lymph nodes during the acute phase of the disease, by examination of semithin sections and electron-microscopic preparations. As have many others, we found strong diffuse B-lymphocyte proliferation, but we must emphasize that many plasmocytes had an obvious defect in cell maturation, but no monomorphous defect. We noted that the predominant postcapillary venules had hypertrophied endothelial and perithelial cells, and multilayering basal lamina. We found some unusual features such as lymphocyte and/or plasmocyte phagocytosis by macrophages, or the atypical aspect of eosinophilic granulations. Finally, in the cytoplasm of a few transformed lymphocytes we detected some viral-like particles resembling herpes virus. Whether this last finding may have been related to the pathogeny of AIL could not be resolved by using morphological techniques. In the second part of this paper, we discuss the etiology of the disease, taking in account our clinical, immunological, and morphological observations. The possible relation of AIL to infectious mononucleosis, and the hypothetical role of Epstein-Barr virus are discussed.

Acute Disease↗
PubMed1979

[Quantitative study of the medullar fibrosis in 84 cases of idiopathic myeloid splenomegaly (author's transl)].

84 bone marrow biopsies were analysed by quantification methods with Classimat. The initial diagnosis was: idiopathic myelofibrosis with splenomegaly. A previous study divided the patients among three categories, according to the classification in three progressive stages of the bone marrow disease. The quantitative lecture was done after reticulin coloration, "in blind", and on several biopsies from the same patient. The results show good correlation with classical histologic methods. The quantitative measure of fibrosis is already important as soon as the first stages of the disease. Correlations with prognosis are more difficult to define.

Biopsy↗
PubMed1979

Primary lymphomas of bone (so-called ("Parker and Jackson's reticulum cell sarcoma") : histological review of 75 cases according to the new classifications of non Hodgkin's lymphomas.

75 cases of primary lymphomas of bone ("reticulum cell sarcoma" described by Parker and Jackson) were reviewed. Biopsy specimens were classified according to several histological classifications, including Lukes' classification for nodal lymphomas. Among 24 tumors described as "histiocytic lymphomas" in Rappaport's classification of 1966, only one case remains as "true histiocytic sarcoma". The others were reclassified as follows : 6 tumors with a predominance of large cleaved cells, 13 tumors with large non-cleaved cells, 2 as immunoblastic tumors and 2 as unclassifiable. In non Hodgkin's lymphomas, the histological diagnosis and the results of the initial staging have been shown to be greater aids in the prediction of survival than the primary site of the disease. Therefore, the clinical and therapeutical approach to the patients with lymphomas of bone must be modified to be similar to that of patients with nodal localisations of the disease.

Adolescent↗
PubMed1979

[Results of the radiotherapy in the non Hodgkin's lymphomas treatment (author's transl)].

In our 98 patients all treated by association chemotherapy + cobaltherapy, 37 cases were stages III and IV and 71 cases were of diffuse pathology classification. Meanwhile the results were not so poor: 66% at 5 years survival (all stages) and 69% for stages I and II. The curves of survival rate generally stabilize at 7 years. The prognostic depend of the pathology class: diffuse LBS and diffuse HBS have an evolution similar to acute leukemia (44.5% and 19% at 7 years survival), on the opposite nodular LBS, diffuse LCS have 100% survival at 7 years. Diffuse cases have visceral relapses (liver, bone marrow, Waldeyer ring) or generalized lymphatic involvement; nodular cases have generally localized and only lymph-nodes relapses. The best results by large fields irradiation suggest a contiguous extension of the disease, but there is also distant lymph nodes relapses. In the nodular cases, relapses can be generally cured by localized radiotherapy. In the diffuse case, we do not know if it is better to give total lymphnode irradiation (or to give more chemotherapy with economic irradiation). 10 gastro-intestinal cases were treated by moving strip technique with excellent tolerance and 67.5% at 5 years survival. These results show that interesting results may be obtained in non Hodgkin lymphomas by association of chemotherapy, with selective and moderately large fields irradiation, even in disseminated cases, even in diffuse cases.

Antineoplastic Agents↗
PubMed1978

[Gas chromatography analysis of volatile monocarboxylic aliphatic acids (C2 to C6) of 15 strains of Veillonella of oral origin].

A qualitative and quantitative study has been carried out on 15 strains of the Veillonella genus, isolated in the oral cavity. Following two methods of preparation of samples for injection in a chromatograph GL, we have identified among the volatil monocarboxylic aliphatic acids from C2 to C6 the glucose fermentation products of these different strains. With the same methods, we studied in parallel these products from strains A.T.C.C. 10790-17444 (Veillonella parvula) and 17445-17446 and 17447 (Veillonella alcalescens). The results, despite the diversity of origin of all these strains, based on physiological and biochemical characteristics, confirm that volatil monocarboxylic aliphatic acids are characteristic of a genus specificity and not of a species. The presence of acetic acid, proprionic acid and iso-valeric acid was shown

Chromatography, Gas↗
PubMed1976

Anti-EBV antibody titers in non-Hodgkin lymphomas.

Antibody titers to Epstein-Barr virus (EBV)-related antigens, i.e. viral capsid antigen (VCA), the D and R components of the early antigen (EA) complex and the EBV-associated nuclear antigen (EBNA), were determined in a series of 86 patients with non-Hodgkin lymphomas and in 150 matched control subjects. The lymphoma patients belonged to four histological groups: diffuse, nodular, hyperbasophilic malignant lymphoma (HML) and unclassified. The EBV-related serological data were compared to the incidence of antibodies to other herpes viruses, i.e. cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella zoster virus (VZV), and correlated with immune disorders, which are particularly frequent in the HML type of lymphoma. The results revealed a significantly higher incidence of anti-EA-D titers in lymphoma patients and slight but significant increases in the geometric mean anti-VCA titers in the HML and unclassified group of patients. These elevated anti-EBV titers in patients were not associated with an increase in titres of antibodies to other herpes viruses. They did not correlate with the signs of immune deficiency observed or with the incidence of auto-antibodies.

Adolescent↗
PubMed1976

[Ultrastructural study of human pulp cells cultured in vitro].

Primary cultures from human dental pulp were produced in Leighton tubes in the compound nutritive medium of Eagle consisting of calf serum, ascorbic acid, penicillin and streptomycin. After 2 months, the coverglasses supporting the cultures were recovered and fixed for electron microscopy. The results obtained showed a polarisation of the cells, the presence of a cilium, a highly developed endoplasmic reticulum, a typical Golgi apparatus with coated vesicles in the vicinity, elongated dense secretion vesicles containing a cross-striated filamentous material, numerous mitochondria, microfilaments with thickenings, microtubules, secretion granules, multivesicular bodies and electron dense structures united by a fibre with a periodic cross-striation of 640 A. These cells secreted a collagenous matrix uith an at random fibrillar distribution, fusiform outlines of fibrils (diameters varying from 650 A to 3,600 A), a cross-striation of 640 A and the presence of electron dense zones on the fibrils. "Globules" (with a trilamellar membrane of about 110 A) were identified in the extracellular medium. The possible comparisons between the typical characteristics of these cells and those of the odontoblast and pulpal fibroblasts were discussed.

Cell Nucleus↗
PubMed1975

Non-Hodgkin's lymphomata: clinical and immunological data in relation to histology.

Two hundred and forty-four previously untreated patients seen since 1964 in the department of haematology at Saint-Louis hospital were analysed. Clinical data included results of initial work-up and prognosis evaluated by survival rate matched with principal variables: age, sex, histopathology, staging, incidence of clinical and biological systemic symptoms. Immunological data included results of systematic studies made in each category of non-Hodgkin's lymphomata. Hyperbasophilic lymphoma, a special group recently characterized, is discussed.

Adolescent↗
PubMed1975

Fracture healing.

The sequence of events occurring after fracture is now relatively well understood. Healing takes place in three phases--inflammatory, reparative and remodelling. In each phase certain cells predominate and specific histologic and biochemical events are characteristic. Factors that influence fracture healing are both local and systemic; the former include particularly the degree of local trauma and bone loss, the type of bone affected, the degree of immobilization and local pathologic conditions; the latter include age, hormones, local stress and electric currents. Natural processes of healing should be allowed to take their usual course and interference should be attempted only when there is demonstrable need or substantial advantages for the patient.

Bone and Bones↗