Search PubMed⌕ Search

Biomedical subjects

J Dry

Publications and source records attributed to J Dry.

At least 91 records · Page 5Linked to original sources
PubMed1985

A comparison of flunisolide inhaler and beclomethasone dipropionate inhaler in bronchial asthma.

Ninety-nine patients, who had never previously taken inhaled steroids were enrolled in a randomized, single-blind, parallel study, the aim of which was to compare the efficacy and safety of flunisolide inhalation, 500 mcg twice daily, with beclomethasone dipropionate inhaler 100 mcg four times daily for the treatment of chronic asthma. The treatment period was for 6 weeks. The patients were examined clinically at entry, week 3 and week 6 and both treatment groups showed a marked improvement in almost all parameters during the course of the study. Flunisolide was statistically significantly superior to beclomethasone dipropionate for wheezing at week 6, coughing at week 6 and chest tightness at weeks 3 and 6. The number of asthma attacks per day decreased significantly more with flunisolide treatment than with beclomethasone dipropionate. The over-all evaluation of efficacy by both doctors and patients also showed flunisolide to be superior to beclomethasone dipropionate. In several other parameters there was a trend shown favouring flunisolide, and beclomethasone dipropionate did not show a superiority over flunisolide in any efficacy parameter. Both drugs were well-tolerated, with unpleasant taste being the most frequent complaint in the flunisolide group. No patient in either group withdrew from the study because of adverse events. In this study, flunisolide inhaler was more effective than beclomethasone dipropionate inhaler for the treatment of chronic asthma exhibited by patients who had never been treated with inhaled steroids.

Adolescent↗
PubMed1985

[Alcohol and urticaria].

The relationship of alcohol intake and urticaria is complex. The mechanism of action may be related to a hypersensitivity reaction to ethyl alcohol or to the other components of alcoholic drinks. Urticaria may also result from the pharmacological effects of alcohol or from the histamine content of the drink. The authors review the literature about hypersensitivity to alcohol and to the different components of alcoholic drinks, especially added compounds. The appropriate sensitivity tests for making this diagnosis are described.

Alcoholic Beverages↗
PubMed1984

[Acyclovir].

Explore the source record for details and available documents.

Acyclovir↗
PubMed1984

[Anaphylactoid accidents during general anesthesia. Apropos of 55 cases].

Analysis of fifty-five anaphylactoid accidents during general anesthesia (GA) in fifty patients shows significant female predominance (70%), relatively frequent allergic predisposition (34% as compared to 14.3% in a normal population) and fairly frequent responsibility of suxamethonium and succinylcholine. One or more, even recent, previous GAs do not seem to enhance the risk. 50% of intradermal skin tests to different anesthetics were negative, 40% were positive and consistent with clinical history, and 10% were positive but inconsistent clinically. Biological tests (basophil degranulation, lymphoblast rosettes, in vitro consumption of complement) were negative. Physiopathological mechanisms remain uncertain, whether they involve IgE allergy or complement activation. The frequency and severity of these unpredictable accidents must stimulate clinical and biological research in this field.

Adult↗
PubMed1984

Tests for allergy to housedust.

In an attempt to find a satisfactory combination of method and antigen extract for tests of hypersensitivity to housedust, variations of skin test, RAST, histamine release and basophil degranulation tests have been used to test efficacy of five commonly used extracts of housedust or its components. The Lincoln Multitest for skin prick tests in its present form induced too much trauma for type-I hypersensitivity tests, though it has advantages for comparison of several extracts. Histamine release and two versions of basophil degranulation tests all gave good results but not consistently. RAST gave the best correlation between all extracts, but neither the in vivo nor in vitro tests gave perfect concordance with sensitivity in all patients and all extracts.

Adult↗
PubMed1984

[Diagnostic value of the human basophil degranulation test in schistosomiasis].

The human basophil degranulation test (HBDT) was applied to the diagnosis of schistosomiasis. In 120 cases confirmed by parasitological examination, the test was shown to be extremely sensitive (90% clearly positive responses) and specific. The total immunoglobulin E levels were higher in infested subjects (average value: 2,000 IU/ml) compared to an average of 500 IU/ml in control subjects. However, wide individual variations were observed and other parasitoses can also produce considerable increases. The measurement of specific IgE showed a clear response with high positive levels in patients with bilharziasis whereas the response was always negative in the controls.

Adult↗
PubMed1984

[Sensitization by repeated skin tests with candidin and PHA].

Intra-dermal skin tests (IST) were applied with candidin (1:100) in 37 subjects and repeated 10 days later. The induration diameter of the second injection (read at 48 h) was greater (p less than 10(-8]. A correlation (r = 0.76, p less than 0.001) appears between the first and second induration diameters. In 17 of these patients (randomly distributed) we measured the absolute number of mononuclear cells bearing receptors of Fc IgG (RFc) before the first and before the second injection. The number of RFc was greater (p less than 0.02) after the second injection. It may be possible that candidin testing increase T suppressor cells. In 20 other subjects, we observed an increase of induration diameter (p less than 0.05) after a second IST of PHA (2 micrograms) applied 15 days after the first injection. Repeated IST with candidin and PHA induce a very high level of booster phenomenon. This fact may be kept in mind when interpreting serial IST in immunodeficiencies.

Aged↗
PubMed1983

[Role of platelet serotonin in common migraine. Concentrations and uptake].

Concentrations and uptake of platelet conjugated and unconjugated serotonin were measured in 15 healthy subjects and in 19 patients with common migraine. Venous blood was taken between migrainous attacks in all patients and during attacks in 8 of them. A significant decrease in unconjugated serotonin concentrations was observed during the attacks, whereas conjugated serotonin concentrations were the same as in controls. In addition, migrainous attacks were accompanied by a significant decrease in serotonin uptake by the platelets, with fall in Km, Vmax and -y. This abnormality was corrected when platelets removed from patients during attacks were incubated in plasma from controls, but it persisted when platelets from controls were incubated in plasma taken from patients during attacks. These findings suggest that one or several factors present in plasma are responsible for the decrease in serotonin uptake observed during migrainous attacks. Finally a study of correlations between these changes and the time elapsed since the last migrainous attacks demonstrated cyclic variations in abnormalities between attacks.

Adult↗