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Biomedical subjects

J Dietrich

Publications and source records attributed to J Dietrich.

At least 145 records · Page 8Linked to original sources
PubMed1976

[The effect of caffeine on action potentials induced by noradrenaline in the depolarized heart ventricle of the rat].

In Rat myocardium depolarized by high external KCl concentration, norepinephrine restores excitability in the form of slow rising electrical responses. Caffein alone does not induce such responses. This result agrees with the hypothesis that caffein reduces the slow inward current in the Rat myocardium. Caffein increases the effects produced by norepinephrine. This suggests an indirect action of the caffein on the calcium permeability mediated by intracellular AMP cyclic level.

Action Potentials↗
PubMed1976

Effects of taurine on the transmembrane ionic currents of rat and guinea pig ventricular fibres.

The effects of taurine on electrical properties of isolated myocardial ventricular fibres were studied in rat and guinea pig. The action potential amplitude was decreased in these species while the plateau and the repolarization phase were not altered. This suggests that simple inspection of the plateau phase is not sensitive enough to pick up changes in outward current since voltage clamp experiments showed that taurine decreased both potassium current and fast inward current. However, the slow inward calcium current remained unchanged with taurine in each species. These results suggest that the inotropic effects of taurine on rat and guinea pig heart contraction already described, were not due to modifications of the cell membrane permeability for calcium. It seems more reasonable to assume that the cardiac actions of this compound result from intracellular changes in calcium availability.

Action Potentials↗
PubMed1975

[Effect of taurine of the membrane electrical properties in guinea pig hearts].

The effects of taurine on electrical properties of isolated ventricular fibres were studied in guinea pig. The action potential amplitude was decreased while the plateau and the repolarization phase was not altered. Voltage clamp experiments at 18 degrees C revealed that taurine reduced the fast inward sodium current and the potassium current. The slow inward calcium current remained unchanged. These results suggest that the inotropic effects of taurine on guinea pig heart contractions already described were not due to modifications of the membrane permeability for calcium but rather to intracellular changes in calcium availability.

Action Potentials↗
PubMed1975

Acute non-traumatic transverse syndrome from a neurosurgical standpoint.

With a seventh of 233 neuro-surgical patients operated on in the area of the spinal canal, an acute or sub-acute transverse syndrome had become manifest before operation. The analysis of these cases shows that 2 out of 12 cervical, and 12 out of 100 lumbar cases of dislocation of the disk cause an acute or sub-acute transverse lesion of the cord with paraplegia. In 56 cases of intradural extra-medullary tumours, no acute development was observed. However, this was seen in 55% of the extra-dural tumour growths. The role of a vasal component in the event of speedy development of the transverse symptomatology in such cases is mentioned.

Hemangioma↗