Biomedical subjects
Publications and source records attributed to J Dickson.
The DNAs of a number of herpesviruses from Australian marsupials have been analyzed using restriction endonucleases, dot-blot hybridizations, and analytical ultracentrifugation in CsCl. The data clearly show the presence of 2 distinct viruses, designated macropodid herpesviruses 1 and 2.
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Allowed 70 undergraduate students to interact for 44 minutes with ELIZA--a computer simulation of psychotherapy. Their responses during the first and second halves of the session were compared, and several differences were found. Removing the effect of the simple volume of responses (using the analysis of covariance) did not change the significance of many of the differences.
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Polioencephalomalacia (PEM) was induced in sheep, with an overall incidence of 63 per cent, using local bracken fern (Pteridium esculentum) rhizomes as a source of thiaminase type 1 and pyridine as a basic cosubstrate. The condition was thiamin responsive and PEM was confirmed by histopathological examination. In a separate experiment to examine the effect of pyridine, it was shown that, for the duration of the experiment, pyridine had no toxic effect and caused no histologically detectable brain lesions.
Various organic hydroperoxides are reduced when added to rat liver mitochondrial suspensions. Succinate increases the rate and duration of the reductions except for linoleic acid hydroperoxide which appears to inhibit its own reduction. 3-Hydroxybutyrate replaces succinate but other reductants used are less effective. The rate of reduction of tert-butyl hydroperoxide by succinate is not inhibited by cyanide but is partly inhibited if antimycin or rotenone are also added; ATP reverses the antimycin inhibition. Other inhibitors include the uncoupler, carbonyl cyanide p-trifluoromethoxyhydrazone, ADP + Pi, the thiol reagents N-ethylmaleimide and p-hydroxymercuribenzoate and inhibitors of the mitochondrial transport of carboxylic acids. In some cases, the GSH concentration of the mitochondria during the reductions correlates with the reduction rate (e.g. with succinate and after N-ethylmaleimide) but in others it is dissociated. The results suggest that hydroperoxide reduction requires the GSH-glutathione peroxidase pathway but that entry of the oxidants into the mitochondrial matrix is also an energy-dependent step.
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