Search PubMed⌕ Search

Biomedical subjects

J Denis

Publications and source records attributed to J Denis.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Budd-Chiari syndrome with massive thrombosis of the subdiaphragmatic venous system and major fibrinopenia (author's transl)].

A 32-year-old patient without previous medical history died within three weeks of acute Budd-Chiari syndrome with massive thrombosis of the subdiaphragmatic venous system. No definite cause could be elicited. The course of the disease was complicated by anuria attributed to hepotorenal syndrome. Laboratory tests demonstrated major fibrinopenia. Detailed study of the haemostatic system was suggestive of hepatic failure associated with consumption coagulopathy of obscure origin.

Adult↗
PubMed1982

Cytochrome c3 from the sulfate-reducing anaerobe Desulfovibrio africanus Benghazi: antigenic properties.

Antisera were prepared against cytochromes c3 from Desulfovibrio africanus, D. vulgaris, and D. salexigens. Cross-reactions were observed between antisera to D. vulgaris and D. africanus cytochromes and heterologous cytochromes c3. A weak cross-reaction with antisera against both D. vulgaris and D. africanus cytochromes and the acid form of the D. salexigens cytochrome was seen; the basic form did not react.

Cross Reactions↗
PubMed1981

Relationship between plasma and brain tryptophan in pigs during experimental hepatic coma before and after hemodialysis with selective membranes.

Experimental acute liver ischemia in pigs induces an increment in plasma free tryptophan with decreased total tryptophan. Brain tryptophan is elevated in all brain areas. A slight, but significant increase of brain serotonin is demonstrated in the striatum only, while 5-HIAA (5-hydroxyindoleacetic acid) is significantly lower in the hypothalamus. Other brain areas do not show significant changes in serotonin and 5-HIAA levels. Neither the high plasma free tryptophan levels, nor the decreased sum of neutral competitive amino acids are consistent with such an elevation of brain tryptophan. Hemodialysis was carried out with two different kinds of membranes: cuprophan (with an efficient removal of molecules up to molecular weight 1300) and AN 69 polyacrylonitrile (efficient removal up to 15,000). Ammonia and aminoacid clearance are similar for both membranes. After AN 69, plasmatic free tryptophan and brain tryptophan are lower than after liver devascularization, but still higher than normal. Serotonin significantly increases in the cortex, midbrain and hypothalamus without concomitant rise of 5-HIAA levels. After cuprophan hemodialysis, plasma total tryptophan is lower than in normal and even comatose animals, whereas free tryptophan is normal. Intracerebral tryptophan is similar to AN 69 dialysed animals, but in the hypothalamus it is similar to nondialysed animals. Brain serotonin levels are not modified. 5-HIAA decreases in the hypothalamus. This finding suggests that middle molecules (which are not cleared out with cuprophan hemodialysis) are involved in the intracerebral transfer of tryptophan and the metabolism of serotonin, mainly in the hypothalamus.

Acrylic Resins↗
PubMed1981

[Antiviral agents and corneal epithelium cicatrisation: study in rabbits (author's transl)].

Five clinically-used antiviral drugs (3% adenine arabinoside ointment; 3% acycloguanosine ointment; 0.24% idoxuridine ointment; 1% trifluorothymidine drops) were compared with a control (petrolatum base) to determine their toxic effects on rabbit corneal epithelium after injury by iodine vapors: --Only trifluorothymidine significantly retarded healing of epithelial erosions. --Histopathologic examination after seven-day treatment showed that all five drugs, except vidarabine and to a lesser degree acycloguanosine, caused toxic changes in the regenerating epithelium.

Acyclovir↗
PubMed1980

HLA antigens and Berger's disease.

We have studied the frequencies of HLA-A, -B antigens in 73 Berger's disease patients, plus HLA-DR antigens in 35 of them, and compared the percentages of antigens frequencies with those of a local and national panel. This study does not confirm the positive associations with HLA-Bw35 or HLA-B12 which have been previously reported. The HLA-DR typing only showed increased frequency of blanks in the patients (P smaller than 0.01, but no significant corr.P). Patients with Berger's disease and renal failure have a higher (but still not significant) HLA-Bw35 frequency than those without renal failure. The reasons for the discrepancy between our group and others are analysed.

Glomerulonephritis↗
PubMed1979

[Complex anal fistulas (author's transl)].

Based on the experience of more than 6 500 patients with perianal suppurations, the authors conclude that the term of ano-rectal fistula should be rejected. The fistulas are rectal (secondary to an organic infection rectocolonic, or iatrogenic) or anal (with a cryptic starting point). The rectal fistulas are always complex for their internal opening being located in the rectal ampulla, they take the sphincteric apparatus as a whole and involve a major risk of post operative incontinence. Some of the anal fistulas are spontaneously complicated. It is the case of fistulas the track of which is located high in the sphincter, of those having multiple extensions, of some horse shoe fistulas with which the communication between the two ischio-rectal spaces is made by unusual passages. Most of them are iatrogenic. Without a doubt the complexity of some fistulas has been favoured by the prolonged and repeated use of antibiotics, but more often they are due to technical faults such as creation of false track during the search of the internal opening towards the superior pelvi-rectal space of towards the rectal ampulla with perforation situated more or less high up. The solution always difficult of therapeutics problems set by such cases should be looked for in the space of time placed between the operations, that alone allows to bring back progressively the complex tracks to their simple tracks.

Anal Canal↗