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Biomedical subjects

J David

Publications and source records attributed to J David.

At least 163 records · Page 9Linked to original sources
PubMed1976

Central nervous system active 5-oxo-1,4,5,6,7,8-hexahydrocinnolines.

Among a series of 5-oxo-1,4,5,6,7,8-hexahydrocinnolines examined for their CNS activity, 1-(2-diethylaminoethyl)-3-(p-fluorophenyl)-5-oxo-7,7-dimethyl-1,4,5,6,7,8-hexahydrocinnoline (23) and 1-(2-dimethylaminoethyl)-3-phenyl-5-oxo-7,7-dimethyl-1,4,5,6,7,8-hexahydrocinnoline (27) had sedative and anticonvulsant properties and were also acitve in tests used to characterize antidepressants. But their narrow safety margin precluded further follow-up studies. Derivatives 35-38 of 2-(omega-phenacyl)-3-hydrazino-5,5-dimethyl-2-cyclohexenone were active in tests used to characterize antidepressants and were weakly sedative but not anticonvulsant.

Animals↗
PubMed1976

Effect of carbamazepine (Tegretol) on seizure and EEG patterns in monkeys with alumina-induced focal motor and hippocampal foci.

Qualitative and quantitative aspects of chronic carbamazepine (Tegretol) medication on focal seizures and associated interictal EEG abnormalities in Rhesus monkeys with alumina-induced foci in either the sensorimotor cortex or the hipocampus was investigated. In both groups of animals, carbamazepine produced qualitative control of visible seizures and reduced intracortical spike propagation, but did not cause complete normalization of the background EEG; quantitative indices, such as spike density and amount of paroxysmal discharge representative of abnormal EEG activity, were significantly reduced with respect to predrug values during medication and after cessation as well. Threshold to pentylenetetrazol was elevated by carbamazepine in both groups of epileptic monkeys. Aggressivity and other clinical manifestations in monekys with hippocampal foci were markedly reduced by carbamazepine.

Aluminum↗
PubMed1976

A comparison of buoyant density and polypeptides of Drosophila P, C and A viruses.

On the basis of their buoyant densities in CsCl and their capsid polypeptides, three viruses isolated from Drosophila spp. which were originally described as serotypes, are now classified as distinct viruses. The biochemical properties of each virus suggest that it has several key features in common with the mammalian picornaviruses.

Capsid↗
PubMed1975

[Resistance to starvation in insects: importance of the amount of lipid reserves in adult Drosophila melanogaster].

At 25 degrees C, mean survival duration of adults starved after emergence varied from 58 to 112 hours, according to genotype and larval growth conditions. This duration was highly correlated with the amount of lipids. The great variability in the amount of lipids (from 15 to 35% of initial dry weight) seems to have an adaptative significance for adult survival in natural conditions.

Animals↗
PubMed1975

[The discovery, in Drosophila, of viruses belonging to three new groups].

Viruses belonging to three new groups have been discovered by the technique used to detect the Picornaviruses. Virus F was found in two French laboratory stocks of D. melanogaster. Virus G and virus RS came from wild flies: a sample of D. melanogaster from Guiana (virus G) and a mixture of different Drosophila species from Singapore (virus G and virus RS).

Animals↗
PubMed1975

Picornaviruses of laboratory and wild Drosophila melanogaster: geographical distribution and serotypic composition.

Picornaviruses were sought in a large number of D. melanogaster strains, coming from laboratories or recently collected from different parts of the world. About a third of these stocks contained viruses. Regions naturally infected were warm countries. Picornaviruses found in laboratories as well as in wild drosophila flies were the already known P and C viruses, of serotype 1 and 2, and a new virus of serotype 3 belonging by its biological properties to the P group. We did not find derological relationship between D. melanogaster and A. mellifera Picornaviruses.

Bees↗
PubMed1974

Cellular hypersensitivity in Guillain-Barré syndrome.

The Guillain-Barré syndrome is hypothesized to be secondary to cellular hypersensitivity to peripheral nerve antigens. To test this theory lymphocytes from 100 subjects were studied using the macrophage-migration-inhibition factor (MIF) assay. Thirty-four normal controls gave a mean migration of 100.4 +/- 9%. Of 34 patients with peripheral nervous system disease, only those with the Guillain-Barré syndrome showed hypersensitivity with a mean migration of 72 +/- 11%. Of 34 patients with central nervous system disease only three with multiple sclerosis and two with stroke gave similar results. Positive results in the Guillain-Barré syndrome were found only in patients presenting with classical disease and who were ill at the time of study.

Antigens↗