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Biomedical subjects

J David

Publications and source records attributed to J David.

At least 181 records · Page 10Linked to original sources
PubMed1975

Picornaviruses of laboratory and wild Drosophila melanogaster: geographical distribution and serotypic composition.

Picornaviruses were sought in a large number of D. melanogaster strains, coming from laboratories or recently collected from different parts of the world. About a third of these stocks contained viruses. Regions naturally infected were warm countries. Picornaviruses found in laboratories as well as in wild drosophila flies were the already known P and C viruses, of serotype 1 and 2, and a new virus of serotype 3 belonging by its biological properties to the P group. We did not find derological relationship between D. melanogaster and A. mellifera Picornaviruses.

Bees↗
PubMed1974

Cellular hypersensitivity in Guillain-Barré syndrome.

The Guillain-Barré syndrome is hypothesized to be secondary to cellular hypersensitivity to peripheral nerve antigens. To test this theory lymphocytes from 100 subjects were studied using the macrophage-migration-inhibition factor (MIF) assay. Thirty-four normal controls gave a mean migration of 100.4 +/- 9%. Of 34 patients with peripheral nervous system disease, only those with the Guillain-Barré syndrome showed hypersensitivity with a mean migration of 72 +/- 11%. Of 34 patients with central nervous system disease only three with multiple sclerosis and two with stroke gave similar results. Positive results in the Guillain-Barré syndrome were found only in patients presenting with classical disease and who were ill at the time of study.

Antigens↗
PubMed1974

Increased thermal stability of chromatin containing 5-bromodeoxyuridine-substituted DNA.

The replacement of thymidine by 5-bromodeoxyuridine in DNA leads to a greatly enhanced stability of chromatin from hepatoma tissue culture or embryonic rat pancreas, as measured by thermal chromatography on hydroxylapatite. The increased stability is directly correlated with the degree of bromodeoxyuridine substitution. On the other hand, the incorporation of bromodeoxyuridine into DNA results in a modest stabilization of purified DNA. Substitution of nucleotide also alters slightly the hyperchromicity profile generated during the thermal denaturation of purified DNA and chromatin. The observed changes can best be explained by an altered interaction between the bromodeoxyuridine-DNA and other chromatin components, presumably proteins. These results suggests that the selective effects of bromodeoxyuridine on cytodifferentiation may be due to an increased affinity of regulatory proteins for bromodeoxyuridine-DNA.

Animals↗