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Biomedical subjects

J D Oriel

Publications and source records attributed to J D Oriel.

At least 73 records · Page 4Linked to original sources
PubMed1982

Epidemiology of chlamydial infection of the human genital tract: evidence for the existence of latent infections.

A group of 536 women attending a clinic for sexually transmitted diseases was investigated for cervical infection by Neisseria gonorrhoeae and Chlamydia trachomatis. Conclusions have been reached concerning the existence and significance of latent and subclinical chlamydial infection of the female genital tract, and on the sexual infectivity of Chlamydia trachomatis to women. The results of the study indicate (1) demonstrable chlamydial infection in 25% of all women attending the clinic for the first time, and in 11% of those with unknown contact history; (2) sexual transmission of Chlamydia trachomatis; 45% of women exposed to chlamydiae contract the infection compared with 75% of those exposed to Neisseria gonorrhoeae; (3) the possibility of reactivation of latent chlamydial infection by Neisseria gonorrhoeae in some women.

Chlamydia Infections↗
PubMed1982

Rosaramicin and tetracycline in the treatment of non-gonococcal urethritis. A comparison of clinical and microbiological results.

The clinical and microbiological outcome of the treatment of 94 men for uncomplicated non-gonococcal urethritis (NGU) was studied. Rosaramicin 250 mg six hourly for seven days was given to 46 men and tetracycline 250 mg six hourly for seven days to 48 men; the follow-up period was up to six weeks. Complete resolution of the clinical signs of infection was seen in 40 (87%) of the men treated with rosaramicin and in 37(77%) of those treated with tetracycline. Chlamydia trachomatis was eliminated from 17 of the 18 men treated with rosaramicin and from all of the 16 men treated with tetracycline. Ureaplasma urealyticum was eliminated from 12 of the 14 men treated with rosaramicin and from 15 of the 19 receiving tetracycline. Clinical recovery correlated well with the elimination of C trachomatis but less well with that of U urealyticum. The two antimicrobial agents were equally effective in the therapy of NGU, but gastrointestinal side effects were significantly more common in men treated with rosaramicin.

Chlamydia trachomatis↗
PubMed1982

Provision of a chlamydial culture service to a sexually transmitted diseases clinic.

Urethral specimens from 215 men were inoculated on to McCoy cell cultures, both at the local laboratory and at a central reference laboratory, Chlamydia trachomatis was isolated from 58 (28%) patients; 12 of these isolates were, however, obtained only at the local laboratory. The results show the feasibility and convenience of a central laboratory supplying a peripheral laboratory with uninoculated prepared cell cultures. Such a service is not only more cost effective but obviates the problems of transporting specimens to a central laboratory.

Bacteriological Techniques↗
PubMed1979

Relationship between sexual intercourse and urinary-tract infection in women attending a clinic for sexually transmitted diseases.

The prevalence of urinary-tract infection (UTI), diagnosed by examination of a single midstream urine from sexually active women was found to be 6.4%. Significant bacteriuria was most common in women who presented within 24 h of coitus but was not related to the number of sexual partners. UTI occurred significantly more often in women who presented within 4 days of intercourse than in women seen after a longer interval. Whether frequency of intercourse affects the prevalence of UTI remains to be determined.

Adolescent↗
PubMed1979

Single-dose minocycline in the treatment of gonococcal urethritis. Clinical efficacy in relation to bacterial resistance and its effects on associated Chlamydia trachomatis infections.

Seventy-two men with gonococcal urethritis were given a single 300-mg dose of minocycline. The failure rate was 13% and the trial was terminated at an early stage. Failure was correlated with increased resistance of Neisseria gonorrhoeae to minocycline. The activity of penicillin, spectinomycin, erythromycin, tetracycline, sulphamethoxazole, cefuroxime, cefotaxime, rosamicin, thiamphenicol, and piperacillin against N. gonorrhoeae were examined in vitro. With the exception of spectinomycin, parallel patterns of resistance to the other antibiotics and minocycline were found. Resistance to spectinomycin was not found, confirming the usefulness of this antibiotic in the treatment of gonorrhoea. The incidence of PGU was significantly lower after a single dose of minocycline than in previous studies.

Anti-Bacterial Agents↗
PubMed1978

Infection of the uterine cervix with Chlamydia trachomatis.

For identification of those variables in the history and in the clinical and routine laboratory examination that are most likely to indicate infection of the uterine cervix with Chlamydia trachomatis, 284 women attending a venereal disease clinic were studied, were studied, of whom 58 (20.4%) yielded the organism from the cervix. Women with chlamydial cervical infection showed no distinctive symptoms. Although associations were found between the presence of C. trachomatis and cervical discontinuity, purulent cervical exudate, and inflammatory changes in cervical cytology, these signs were not pathognomonic of chlamydial infection since they were also seen in some women infected with other microorganisms. There was a significant relationship between the presence of antibodies, detected by immunofluorescence, and the recovery of C. trachomatis in cell culture. There were no associations between ethnic group, history of sexually transmitted disease, method of contraception, phase in the menstrual cycle, or numbers of sexual contacts and infection with C. trachomatis.

Adolescent↗
PubMed1978

The antimicrobial susceptibility of Chlamydia trachomatis in cell culture.

The action of 22 antimicrobial agents against the SA2f strain of Chlamydia trachomatis has been studied by the use of a simple cell culture technique. Tests for bactericidal activity were undertaken with some of the agents, and latency of infection was demonstrated. The susceptibilities of 10 clinical strains of C. trachomatis and of SA2f to oxytetracyline, erythromycin, and spectinomycin in cell culture were found to be identical.

Anti-Bacterial Agents↗