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Biomedical subjects

J D Beck

Publications and source records attributed to J D Beck.

At least 181 records · Page 10Linked to original sources
PubMed1985

[Hexosaminidase activity in cell lines, serum and urine of leukemia patients in childhood].

N-Acetyl-beta-D-Hexosaminidase (E.C. 3.2.1.30) activity was investigated in cell lines, urine and serum of leukemic children by various biochemical methods for its usefulness in classifying different types of leukemia. We demonstrated in our small series that the activity of the I-isoenzyme of hexosaminidase in serum was dependent on the amount of tumour burden at the beginning of induction therapy. However it was not specific for a certain type of leukemia. In contrast to other reports an increased hexosaminidase-I-activity was found not only in C-ALL-cell lines but also in a T-ALL. Furthermore our results exclude any diagnostic value of urine hexosaminidase for the classification of leukemias.

B-Lymphocytes↗
PubMed1984

Removable prosthodontic treatment needs: a survey.

Population data on complete and removable partial prosthodontics in Iowa indicated the following. Denture wearers tend to be persons in the older age groups. The percentage of edentulous persons was lower than that reported nationally in 1971. Of every 1,000 persons, 156 were wearing dentures in one or both arches. Of every 1,000 persons, 53 needed a repair, reline, or replacement of an existing denture. Of every 1,000 persons, 70 needed a denture but were not wearing one. Persons of lower income and education were less likely to seek dental care but had the greatest need for treatment. Persons of lower income and education were at higher risk of having some form of mucosal lesions. The public will be unlikely to make use of dental services to prevent or treat lesions or to service a prosthesis unless they are specifically educated to do so.

Adult↗
PubMed1984

Risk factors for various levels of periodontal disease and treatment needs in Iowa.

A cross-sectional study of the non-institutionalized population of the State of Iowa was completed in 1980. Persons were interviewed by telephone and a follow-up dental examination was conducted in the home. Periodontal treatment needs were measured using the WHO-621 Index of Periodontal Treatment Needs which has been modified and is now known as the Community Periodontal Index of Treatment Needs. Findings were consistent with other recent studies, which have shown a relatively high proportion of gingival bleeding and calculus. Although moderate pocket formation (3-6 mm) occurs in approximately 30% of the adult population, complex treatment needs (pockets 6 mm or greater) occurred in only 1.3% of the population. While sex did not significantly affect the distribution of periodontal needs; age, recency of visit to the dentist and income are possible risk factors for serious periodontal disease.

Adolescent↗
PubMed1983

Primary polycythaemia in childhood and adolescence.

Four adolescents with polycythaemia are described where symptoms typical of the disease had already existed in childhood. Three patients fulfilled the criteria of a polycythaemia vera. In one female patient the possibility of familial erythrocytosis is discussed. Polycythaemia vera mononuclear cells formed erythroid colonies in cultures in the absence of erythropoietin. The patients were phlebotomized to maintain haematocrit readings of 40 to 45%. No case has yet progressed to myeloid metaplasia or acute leukaemia.

Adolescent↗
PubMed1983

Medical and psychosocial risk factors in the dental treatment of the elderly.

There is evidence to show that a 'new' type of elderly consumer of dental services is evolving with characteristics and expectations different from those of the 'old' elderly that dentists have had experience in treating. In providing care for the 'new' elderly the dentist must consider the many modifying factors which influence the type of treatment that an individual patient needs. These are the patient's lifespan, medical history, drug history, mental status, mobility, neuromuscular coordination, dental status, previous dental experience, the patient's or family's dental expectations as well as the economic status of the patient and the family. Before commencing treatment the dentist must also assess his/her own skills, the facilities in which he/she is working and the availability of equipment to carry out the dental procedures that may be required. Only when all of these considerations have been taken into account can rational dental care for an individual elderly person be planned and completed. The variation in what is rational is large. For one patient it may be no treatment at all and for another the most technologically sophisticated care dentistry can provide.

Aged↗
PubMed1982

Sociomedical and behavioural aspects of dental care for the elderly: statement of the problem.

In providing dental care for the elderly, dynamic changes in disease states and population groups must be recognized. These are creating a need for the dental profession to address itself to the increasing complexity of dental treatment required for ageing populations. The existence of different populations of elderly has implications for geriatric dentistry. There are similarities between the problems in countries with ageing populations, isolated from society, and the problems in countries without such populations, but with the problem of accessing other isolated populations.

Aged↗
PubMed1982

Dental students' confidence in prosthodontics and attitudes toward the elderly.

Data were examined concerning dental students' confidence in removable prosthodontic treatment and their attitudes toward elderly persons before and after a ten-week clinical prosthodontic rotation. The Rosencranz and McNevin Aging Semantic Differential (SD) Scale was used to measure attitudes regarding the elderly; another SD was designed to measure confidence in removable prosthodontics. Both student's attitudes toward elderly persons and their confidence in carrying out removable prosthodontic treatment improved significantly after the rotation; the greatest improvement occurred when students treated patients of all ages. There was a significant relationship between confidence in performing removable prosthodontic treatment and clinical grades, but not didactic grades.

Aged↗
PubMed1981

T-lymphocyte subpopulations in the peripheral blood of patients with Crohn's disease.

Samples of peripheral blood from 26 patients with Crohn's disease (CD) and 26 healthy age- and sex-matched controls were tested simultaneously for B and T lymphocytes and T-lymphocyte subpopulations with receptors for IgM (TM) and IgG (TG). Patients with CD had reduced proportions of T lymphocytes, and this reduction showed a significant correlation to the CD activity index (r = -0.65, p less than 0.01). There was slight reduction of TM only (p less than 0.05) inpatients with highly active disease but not in the total population of patients studied. Proportions of B and TG cells were similar in patients and controls. Patients with no clinical or radiological but histological signs of active disease had T lymphocytes and subpopulations like patients with inactive disease. This suggests that the reduction of T cells and T-cell subpopulations in CD are secondary effects. With regard to T-lymphocyte subpopulations, our results are in contrast to a recently published report and do not suggest that analysis of T cells according to the expression of Fc receptors helps in the understanding of functional changes in the T-cell system in patients with CD.

Adolescent↗
PubMed1980

Subpopulations of human T lymphocytes. VI. Analysis of cell markers in acute lymphoblastic leukemia with special reference to Fc receptor expression on E-rosette-forming blasts.

A variety of surface markers, terminal deoxynucleotidyl transferase (TdT) activity, morphologic appearance, and cytochemical composition were studied in a group of 16 patients (13 children, 3 adults) with acute lymphoblastic leukemia (ALL). In 9 children, no surface markers were detected on lymphoblasts (null-type ALL). Leukemic blasts of 4 children formed E-rosettes. These E-rosette-forming blasts from 3 adult patients with ALL, were studied for the presence of Fc receptors. Of the leukemic blasts from these 7 patients, 2--76% expressed receptors for IgG Fc. Only 3 of 7 patients showed 9--42% receptors for IgM Fc. In addition, complement receptors were investigated in 6 of those 7 patients with T-cell ALL. Complement receptors were detected on 9--70% of the E rosette forming blasts from all 6 patients. TdT activity was elevated in T-cell ALL and in children with null-type ALL. The heterogeneity of Fc receptor expression on leukemic blasts in these patients demonstrates a malignant proliferation of T cells in different stages of differentiation or maturation. This observation might be helpful in subclassifying T-cell leukemias with regard to prognosis and the response to therapy.

Adult↗
PubMed1980

Childhood CML in blastic stage: an analysis of cell markers and cell kinetics.

The clinical course of Ph+CML and their terminal blastic stage is described in the following case histories. During blastic phase, cell surface markers, terminal deoxynucleotidyl transferase (TdT) activity, and flow cytometric measurements were used or determination of the blast cell phenotype which was undifferentiated by morphological and cytochemical criteria. A high proportion of blast cells expressed Fc receptors for IgG, TdT activity was normal in both children and RNA measurements of single cells flow cytometry showed a high RNA content in the majority of blasts. These findings are compatible with the phenotype seen in the myelomonocytic leukemias. Flow cytometry appears to be a useful adjunct to immunological methods and TdT activity for the rapid characterization of CML in blastic phase.

Child↗