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Biomedical subjects

J Craig

Publications and source records attributed to J Craig.

139 records · Page 8Linked to original sources
PubMedDate not supplied

Through a dark glass more clearly? Health information managers and strategic planning in the 1990s.

This article considers the application of a formal strategic planning approach to the health information management profession. After a brief discussion of the two main strategic planning models, the process adopted by the Health Information Management Association of Australia at its recent strategic planning workshop is described and the planning outcomes are outlined. The merits of explicitly expressing strategic intent through the creation of a vision of the future and the establishment of strategies and an action plan to realise the vision are discussed.

Australia↗
PubMedDate not supplied

The mutagenicity of saccharin impurities. I. Detection of mutagenic activity.

Sodium saccharin, ortho-toluenesulfonamide and impurities extracted from commercially produced saccharin with water and organic solvents were tested for mutagenicity with strains of Salmonella typhimurium. The organic solvent soluble impurities exhibited strong mutagenic activity for TA98 and slight activity for TA100. Mutagenic activity for S. typhimurium TA98 was demonstrated in extracts of some but not all lots of sodium saccharin produced by both Maumee and Remsen-Fahlberg processes. The significance of the mutagenic impurity to the carcinogenicity of saccharin is discussed.

Drug Contamination↗
PubMedDate not supplied

Phase I study of high-dose cytarabine and cisplatin in patients with advanced malignancy.

Nineteen patients with advanced malignancy participated in a phase I trial of high-dose cytarabine (ara-C) and cisplatin in combination. Dose and schedule were based on laboratory data indicating synergy for concurrent use of these drugs. Cisplatin (100 mg/m2) was administered during the 2nd and 3rd hours of a 3-hour ara-C infusion. The ara-C dose was escalated in subsequent patients following a starting dose of 1 g/m2. Two brief responses were noted. The study was terminated prematurely due to protracted (several weeks) nausea, occasional vomiting, and severe lassitude.

Adult↗
PubMedDate not supplied

Cell membrane signals in the mechanism of insulin action. Claude P. Brown memorial lecture.

Present evidence points to the rapid formation of one or several mediators by proteolysis initiated by insulin and, possibly, other hormones. Mediators act intracellularly at a number of subcellular sites, including cytoplasm, mitochondria, endoplasmic reticulum, cell membrane, and nucleus (figure 9). These mediators control enzymes that are controlled by covalent phosphorylation. As a result, the mediators impart an overall integrated control of metabolism. Evidence strongly suggests that the mediators are peptides. They appear to be formed by limited proteolysis from cell membrane proteins or glycoproteins and act as transmembrane signals following the binding of insulin to its receptor and the activation of the insulin-receptor complex.

Animals↗