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Biomedical subjects

J Conde

Publications and source records attributed to J Conde.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Connection between two peripherical markers in a group of asthmatic patients.

We have studied the goniometric value of the tda angle and the alpha 1 antitrypsin phenotypes in a group of thirty atopic patients with the following patterns: 1) they were affected with asthma, atopic dermatitis and rhinitis. 2) they presented positive prick skin tests for pneumo-allergens and had. 3) positive allergic antecedents. There exists a significant statistical value for the lower tda angle in the right hand, in the MZ phenotypes of alpha 1 antitrypsin bearers, with P less than 0.05 significance. In the left hand there are many individual values that are identical (62% of the total test effected) thus the statistical methods cannot be applied satisfactorily, bearing in mind the significant difference as the statistical group recognized. From this and other previous works, we can conclude that an individual whose right hand tda angle reaches values near 75%, and with a MZ phenotype of alpha 1 antitrypsin, has a greater possibility of pertaining to one of the groups of asthma, atopic dermatitis and rhinitis symptomatology.

Asthma↗
PubMedDate not supplied

Phenotypes of alpha-1-antitrypsin in intrinsic asthma and ASA-triad patients.

The frequency of presence of various phenotypes of alpha 1-antitrypsin was studied in 31 patients with intrinsic asthma and 11 with ASA-Triad, and compared to a group of 200 people representative of the general population. The MZ and SZ phenotype is more frequent in intrinsic asthmatics (p < 0.00001) and MZ in ASA-Triad (p < 0.0005) than in the control group. No differences were found between the intrinsic asthmatics and ASA-Triad. All the patients were divided into groups according to their clinical characteristics and an increase of the MZ phenotype was observed (p < 0.001) in patients with: nasal polyposis, intolerance to non-steroidal anti-inflammatories, a family history of atopy and peripheral eosinophilia (p < 0.01). Alpha-1-antitrypsin deficiency could be important in the pathogenesis of inflammatory processes and in the clinical manifestations characteristic of patients with intrinsic asthma and ASA-Triad.

Adult↗
PubMedDate not supplied

Variations of the cellular antigens CD4 and CD8 in pollinic patients during the spring.

In order to study the possible variations of CD4 and CD8 antigens in pollinic patients, we have studied 25 individuals (11 rhinoconjunctivitis and 14 rhinoconjunctivitis-asthma) before (T0), in the middle (T1) and after the spring (T2). The number of receptors per cell of CD4 start from values in T0, decrease in T1 and increase at the end of the spring (p < 0.00001), which could represent a mechanism to limit the clonal response to an antigen. An increase in the CD4/CD8 bright ratio could be indicate a higher helper mechanism in T1 with respect to T0 and T2 (p < 0.01). The opposite meaning is to given to the increase of CD8bright receptors in the asthmatic patients, and not only in those who suffer only from a rhinopathy (the only difference between the two groups of patients) during T2 over the T1 (p < 0.00001). The greater number of lymphocytes CD8 dim + during T1 with respect to T2 (p < 0.009) and the increase in the number of receptors of such cells during T1 with respect to T2 (p < 0.00001) suggests a possible intervention of these cells in the regulation of the response of the B and T lymphocytes. Of the two soluble factors CD4 (sCD4) and CD8 (sCD8), only the sCD4 increases during T1 (p < 0.0001) in an inverse manner as occurs with CD4 cell receptors, while the sCD8 remains unchanged during the three periods.(ABSTRACT TRUNCATED AT 250 WORDS)

Asthma↗
PubMedDate not supplied

[Cancer and geriatrics].

Undoubtedly we are living in a world where life expectancy is growing larger and birth rates are decreasing; in the western world we are slowly progressing towards a world of elderly people. Such forecast rises a challenge with two multidisciplinary fronts: stabilizing or controlling the biological processes of aging. Since we cannot interfere with the genetic predetermination of life, the choice could be to block the events that might alter such genetic programme, preserving our genetic inheritance, as well as promoting a healthy life style and preventing diseases acquired through life. We must create social and economic conditions that permit more and more elderly people to be active members of the community, with preserved or restored mental and working capacities. There are several factors that can interfere with the life programme that is biochemically impressed in our genetic inheritance, by changing or disrupting homeostasis and thus provoking aggression or instability factors, within what I use to call the biological sociology of the human being. Among such factors, cancer prevails as a complex biological process that settles in the human body like a biological terrorist, and evolves to a nosologic process--cancer disease--that threatens life, first leading to disease and afterwards causing a genetically non expected death. Epidemiological studies show that age-related risk is a reality that neither individual involvement nor the New Biology resources can surpass. Therefore, I thought that Cancer and the Elderly would be an interesting subject, according to the following: 1. Topics on demography and geriatrics.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMedDate not supplied

Plasma kallikrein amidolytic activity in patients with urticaria.

We have studied the plasma kallikrein amidolytic activity in healthy control subjects (inactive), patients with chronic urticaria (active) and patients with acute urticaria (active) from their admission to the emergency room (active) to the time after which their clinical symptomatology had disappeared (inactive). We found statistically significant differences (p < 0.01) in the active groups of urticaria patients. This leads us to believe that kallikrein participates in the development of symptomatology in these patients.

Female↗
PubMedDate not supplied

Production of soluble CD23 from peripheral blood lymphocytes of asthmatic patients.

The low-affinity receptor IgE (Fc epsilon RII) as shown to be identical to CD23 several years ago. The presence of the CD23 was demonstrated on a variety of human cells, such as T cells, monocytes, eosinophils, platelets, lymphocytes B, etc., and it can be cleaved in soluble fragments. We studied the in vitro production of soluble CD23 (sCD23) in PBMC of patients with bronchial asthma and in healthy donor cells. If we stimulate production with a polyclonal activator [Phytohemagglutinin (PHA) at a concentration of 10 micrograms/ml], it can be seen that the greatest amounts of sCD23 are produced on the fourth day and that production is greater in asthmatic patients than in control group (p < 0.01). When stimulated additionally by an antigen, the production of sCD23: Is greater when stimulated with PHA. Is released in quantities greater than in healthy group cells, when the PBMC are stimulated with the antigen to which the patients are sensitive (olive pollen). The quantity released depends on the concentration of the antigen added to the culture. Is not released in greater quantities by healthy groups cells in the presence of the antigen than in healthy group cells without the antigen. Is not released in greater quantities by cells of asthmatics in the presence of an antigen to which they are not sensitive (D. pteronyssinus). This leads us to conclude that the release of sCD23 in these patients could play a role in the physiopathology of extrinsic bronchial asthma.

Allergens↗
PubMedDate not supplied

Relationship of blood EG2+ eosinophils in patients with bronchial asthma.

The presence of eosinophils in peripheral blood has been previously associated with different degrees of activity in the evolution of disease in asthmatics. The eosinophil cationic protein is a mediator released by the eosinophils when they are activated due to various stimuli. The monoclonal antibody EG2 binds to human ECP, the epitopes which EG2 recognizes is only present in the secreted form of ECP, hence it only stains eosinophils which are undergoing activation and/or secretion. Flow cytometry was used to measure the level of eosinophils stained by the monoclonal antibody EG2 (eosinophil EG2+) in the peripheral blood of subjects with unstable extrinsic bronchial asthma, stable extrinsic bronchial asthma and healthy control group. A statistically significant higher level of eosinophil EG2+ was found in the group with unstable asthma than in either the group with stable asthma or the group of healthy subjects (p < 0.0002). No difference was found between the patients with stable asthma and the control group. The level of eosinophil EG2+ in peripheral blood, measured by flow cytometry, could be used as an indicator of inflammatory activity in patients suffering from bronchial asthma.

Animals↗
PubMedDate not supplied

Unusual course of the hepatitis C virus infection in one patient diagnosed of common variable immunodeficiency.

Common variable immunodeficiency (CV1) is defined by low serum IgG and IgA levels, and it is the second most frequent primary immunodeficiency. The indication for treatment with human gammaglobulin in patients with this syndrome has been well established. Here we report a case history of a patient diagnosed of common variable immunodeficiency, and she had treatment with i.v. commercial gammaglobulin. In the course of the disease, she developed symptoms that make us think about the possibility of hepatitis virus infection. HBV-associated antigens and antibodies, and HCV-Ab were all negative. So, amplification of HCV-RNA by polymerase chain reaction (PCR) was performed, and it became positive in two different determinations. Liver failure got worse quickly and the patient died. About the course of the HCV infection, only 30% of patients with acute hepatitis get biochemical resolution, and 50-70% become carriers and have persistent chronic hepatitis or active chronic hepatitis. In this case, HCV infection showed an unusual acute and fatal course, it is possible that the impaired immune status of the patient could play a role in the acute course of the disease. Therefore, every patient who have intravenous immunoglobulin replacement must be monitored regularly for liver function tests, and by PCR for HCV infection.

Adult↗
PubMedDate not supplied

H1-antihistamines and prescription compliance.

H1-antihistamines (H1A) have been used for more than 50 years in the treatment of allergic pathology. Their widespread consumption and the growing pharmaceutical offer is noteworthy. Despite this, we have not found any study on the compliance of these drugs in the scientific literature reviewed. The aims of this study are to evaluate compliance with the prescription of H1A in a sample of allergic patients diagnosed as pollen rhinoconjunctivitis (PRC), and to evaluate the possible association between the degree of compliance and certain patient-dependent parameters (age, sex, cultural level, knowledge of the prescription and treatment [duration, number of drugs, posology, method of administration and appearance of adverse drug reactions]). The sample size was 300, and 164 were attended. Of these 164 patients, 123 claimed to have taken correctly the H1A prescribed by the allergologist. Of the group of patient claiming to have followed treatment correctly, only 8 patients did not remember the number of packs of H1A bought, nor their price, nor the appearance of the tablets (or solution). Regarding the frequency of use, 101 patients took the H1A daily, and the remaining 22, depending on symptoms. Administration of the H1A was always oral-tablets in 114 cases and solution in 9. The compliance we have found is at a medium level, similar to that reported in other studies (although on other drugs), and no significant differences were found in relation to the parameters studied.

Adolescent↗