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Biomedical subjects

J Coll

Publications and source records attributed to J Coll.

At least 127 records · Page 7Linked to original sources
PubMed1981

Incorporation of fatty acids into phosphatidylcholine species by liver homogenates from chick embryos.

Labeled palmitic, stearic, oleic, linoleic and araquidonic acids were incorporated into phosphatidylcholines by incubation with liver homogenates from 13, 17 and 21 day-old chick embryos. Palmitic acid was incorporated into dienoic and tetraenoic phosphatidylcholines whereas linoleic acid was incorporated into dienoic phosphatidylcholines. Labeled palmitic and linoleic acids were specifically found into positions 1 and 2 of the phosphatidylcholine molecule, respectively. Under in vitro conditions, the incorporation of either palmitic or linoleic acids into phosphatidylcholines was 2-3 fold greater in liver homogenates from 17 day-old chick embryos than in those from 13 or 21 day-old ones.

Age Factors↗
PubMed1981

Deacylation and reacylation of phosphatidylcholines by liver homogenates from chick embryos.

Liver homogenates from 13, 17 and 21 day-old chick embryos were incubated with phosphatidylcholine and lysophosphatidylcholine labeled with fatty acids to study deacylation and reacylation reactions of phosphatidylcholines during development. By using phosphatidylcholines labeled with palmitic or linoleic acids in position 1 or 2, respectively, phospholipase A2 activity was detected. By using lysophosphatidylcholine labeled with palmitic acid in position 1, preferential acylation with araquidonic acid was demonstrated. In agreement with this data, the incubation of dienoic phosphatidylcholines labeled with palmitic acid in position 1, with the liver homogenates, gave rise to labeled tetraenoic phosphatidylcholines. The extent of both deacylation and reacylation of the phosphatidylcholine molecule in position 2 by liver homogenates from chick embryos, decreased during development.

Acylation↗
PubMed1980

[Urinary tract infection in postmenopausal diabetic women. Clinical survey of hospital and nonhospital populations (author's transl)].

The incidence and clinical course of urinary tract infections in postmenopausal diabetic patients in comparison to non-diabetic women have been evaluated. All cases with former history of urinary instrumentation or underlying conditions favoring urinary infections were rejected. Urinary tract infection was present in 14.9 percent of postmenopausal diabetics versus 10.5 percent in the non-diabetics. The incidence of urinary tract infection in premenopausal women was 12.5 percent. Urinary pathogenes showed similar incidence rate in both groups: E. coli (41 versus 57 percent), P. mirabilis (20 versus 28 percent) and Klebsiella (11 versus 20 percent). Diabetic women showed a higher rate of sepsis and infection recurrence than non-diabetic (10.7 and 17.8 percent versus 2.6 and 2.6 percent, respectively). Severe impairment of renal function (plasma creatinine clearance > 2 mg/100 ml) was registered in 12.5 percent of postmenopausal patients with diabetes mellitus, but none of the non-diabetics suffered renal damage (p < 0.01).

Aged↗
PubMed1979

Pulpectomy procedure for deciduous teeth with severe pulpal necrosis.

Pulpectomies of deciduous teeth with severe pulpal necrosis should be considered as a possible treatment plan. Systemic and dental criteria have been devised to help the clinician to select cases in which successful results may be produced. A clinical success occurs when the pulpectomized tooth is painless, is firm in its alveolar socket, and is without a fistulous tract. Radiographically, any radiolucent area should be resolving with six months, and no pathologic root resorption should be observed. Research should determine whether pulpectomies may be done on children with severe systemic disease and should determine long-term consequences of underfilled and overfilled pulpectomies.

Dental Pulp Capping↗
PubMed1978

Stimulation of heme accumulation and erythroid colony formation in cultures of chick bone marrow cells by chicken plasma.

A fibrin clot culture system with high plating efficiency is described for the growth of erythroid cells from chick bone marrow. Erythroid colonies grown in the absence of adult chicken plasma (spontaneous colonies) were either benzidine-negative or weakly benzidine-positive. Colonies grown in the presence of chicken plasma were 90% strongly benzidine-positive and 40% more abundant than spontaneous colonies. Plasma from anemic chickens was more effective than control plasma in inducing heme accumulation (heme-stimulating activity) and in increasing the number of erythroid colonies (colony-stimulating activity). Spontaneous colonies from 48-h cultures were transformed into benzidine-positive colonies by exposing them for 6-10 h to chicken plasma.

Anemia↗
PubMed1977

Metabolically dependent and independent cell surface antigens.

In contrast to metabolically dependent tissue-specific cell surface antigens (MDA) which are available for reactions with antibodies only on surfaces of metabolically active cells, the availability of the universally distributed blood group A or Forssman-type antigens on cell surfaces was found to be independent of the metabolic activity of cultured cells. In case of the MDA, cytotoxic reactions were induced by antibodies alone, resulting in a disorganization of the cellular sheet without a significant release of radioactive label. Radioactive release in this cytotoxic reaction was increased by the addition of complement without additionally affecting the degree of cell sheet disorganization. In case of Forssman and blood group A antigens, such morphologically demonstrable cytotoxicity required complement, and the resulting pathology was always accompanied by extensive release of cellular contents. The ability of anti-MDA antibodies to induce cytotoxic reactions in the absence of complement may be related to a vital role of MDA in cellular function.

ABO Blood-Group System↗