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Biomedical subjects

J Colin

Publications and source records attributed to J Colin.

At least 181 records · Page 10Linked to original sources
PubMed1983

Combination therapy for dendritic keratitis with human leukocyte interferon and acyclovir.

We treated 45 patients with virologically verified dendritic keratitis with a combination of interferon and acyclovir 3% or with placebo and acyclovir 3% in a double-masked study. One drop of human leukocyte interferon (30 X 10(6) IU/ml) or albumin-placebo was administered daily. Acyclovir ointment was applied five times daily. The mean healing time of the corneal ulcers in 24 patients treated with interferon and acyclovir was 3.9 days and the mean healing time in 21 patients treated with placebo and acyclovir was seven days. The difference was significant (P less than .001).

Acyclovir↗
PubMed1983

[Evaluation of 80 virologically-confirmed cases of ocular herpes. Study of the correlation between the type of virus and the epidemiologic characteristics of the disease].

80 strains were isolated from patients with herpetic ocular infection during the period May 1979 to May 1981: 17 patients with herpetic blepharitis, 40 patients with superficial keratitis and 23 with deep stromal keratitis or kerato-uveitis. Among 63 patients treated with antiviral agents, clinical resistance to the drug was observed in 17 cases. The strains were typed as HSV 1.1, 1.2 or 2.2 by seroneutralization and thermosensitivity in cellular cultures. No relationship between the viral types and the patient age, previous history of corticosteroid therapy and the response of ocular lesions to antiviral treatment were detected. It appeared that there was a relationship between the viral type and the clinical type of infection: 70% of herpetic blepharitis and 83% of superficial keratitis were due to HSV 1.1 while 71% of stromal keratitis were due to HSV 1.2. No HSV 2.2 was isolated. These results seem to support the hypothesis that genetic differences between herpetic virus strains may determine their virulence.

Adult↗
PubMed1982

[Salivary lysozyme, immunoglobulins and beta 2-microglobulin in Gougerot-Sjögren syndrome].

Lysozyme (LZM), immunoglobulins and beta 2-microglobulin concentrations were measured in the saliva of 79 patients with primary (n = 29) or secondary (n = 50) Sjögren's syndrome and in a control population. beta 2-microglobulin and immunoglobulins A, G and M concentrations were higher, and LZM concentrations lower than in controls. A significant correlation was established between LZM and immunoglobulins, but no correlation was found between immunoglobulins and beta 2-microglobulin, nor between the latter and LZM. These results indicate that salivary LZM concentration may be of value in the diagnosis of Sjögren's syndrome.

Adult↗
PubMed1982

[Accidental localized vaccinia. A report of six recent cases (author's transl)].

Vaccination against smallpox should be discontinued in all countries except for individuals with a high risk of exposure (WHO, 1980). Since this vaccination is performed less and less often, one must expect complications to occur, the etiology of which may not be recognized. This course of events leads the authors to point out the difficulties in diagnosis and therapy of localized accidental vaccinia encountered in six patients hospitalized in Brest (1971-1979). Diagnosis is considered if the patient himself, or a person he came in contact with, was recently vaccinated. Diagnosis should always be established by virology. Such accidents can be avoided by a faultless vaccination technique and by giving sufficient information to the inoculated subject or to his relatives.

Adolescent↗
PubMed1982

Levels of T lymphocytes, but not specific antibodies, reflect clinical presentation in human herpes simplex keratitis.

Total erythrocyte Rosette-forming cells (ERFC) have been found to be decreased in 44 patients with recurrent ocular herpes but normal in 26 patients with the primary form of the disease. Active ERFC have been found to be decreased in 27 patients with herpetic keratouveitis and normal in 43 patients with superficial herpetic keratitis. Antibodies to herpes simplex virus could not be used to distinguish the various clinical presentations of the disease.

Adolescent↗
PubMed1982

[Ocular herpes simplex in children (author's transl)].

A series of 38 children with ocular herpes simplex infection is reported. The follow-up periods ranged between 1 and 10 years after the first ocular herpetic involvement. The primary ocular infection occurred in most cases between 2 and 6 years of age, with a similar rate in males and females. The number of recurrences increased with the duration of the follow-up period: during the first 2 years, recurrences developed in 50% of cases and after 2 years, all the children had new herpetic ocular attacks. Idoxuridine treatment failures were found in 11 cases of herpetic superficial keratitis. Ocular herpes simplex in children is a major cause of visual loss and disability. After a follow-up period of 5 years, 75% of patients with herpetic keratitis had a visual acuity of 5/10 or less.

Adolescent↗
PubMed1982

[Ocular herpes. Correlations between subpopulations of T lymphocytes and clinical manifestations?].

Herpes simplex virus can affect the cornea in many ways, the main differences concerning the evolutive stage and the severity. Using the rosettes technique, we have tried to know if the study of the T lymphocytes subsets may give some help in foreseeing the risk of stromal or recurrent keratitis. Peripheral lymphocytes and T lymphocytes subsets: total E, E-active, autologous rosettes forming cells (E, E-act., auto-RFC) were studied among 60 patients with different clinical manifestations of herpetic keratitis: i.e. 27 epithelial and 23 stromal ones, 20 primary and 40 recurrent keratitis. Two groups of patients were found to have decreased levels of one T lymphocytes subset: the stromal ones with the most serious prognosis had above all a E-act--RFC decrease (16,5 +/- 8,5% vs 24,1 +/- 4,7 for the controls, p 0,001); the recurrent ones had above all a E-RFC decrease (53,6 +/- 6,4% vs 63,7 +/- 8,7 for the controls, p less than 0,001). So the most severe herpetic keratitis: recurrent and stromal ones seem to have cellular immunity abnormalities that are not found in the superficial or primary keratitis.

Adolescent↗
PubMed1982

Measurement of systolic time intervals by electrical plethysmography: validation with invasive and noninvasive methods.

An experiment was conducted to validate the use of electrical impedance plethysmography for measuring systolic time intervals. This method is of interest in aerospace medicine since it is a noninvasive technique and very easy to use without causing discomfort to the subject. The equipment, with electrodes placed in front of the heart, gave both the first derivative of the electrical impedance variation and the E.C.G. The tracings were compared to simultaneous recordings of either the carotid pulse or blood pressures obtained by right and left catheterization. The results did not permit us to determine the right side systolic times. However, demarcated points of the plethysmogram permitted us to determine accurately the beginning of left mechanical systole and aortic opening and closure. Consequently, this method can determine the left ejection time (LPEP), the left isovolumetric contraction time (LIVCT), and the ventricular ejection time (LVET) with good accuracy.

Blood Pressure↗