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Biomedical subjects

J Chang

Publications and source records attributed to J Chang.

At least 559 records · Page 31Linked to original sources
PubMed1976

Pulmonary nocardiosis in an orangutan.

Pulmonary nocardiosis was diagnosed in an adult male orangutan (Pongo pygmaeus) being maintained in an outdoor facility. Periodically, the orangutan had had clinical signs of an upper respiratory tract infection, as evidenced by slight nasal discharge and cough. At the terminal stage, the orangutan had acute respiratory embarrassment, with epistaxis, and died before diagnosis could be made and treatment initiated. Gross necropsy findings included fibrosis of the pulmonary parenchyma as well as evidence of air sac infection, extensive pneumonia, and extensive chronic pleuritis. Microscopically, some of the lung sections had alveoli filled with polymorphonuclear cells, with other sections being diffusely fibrotic; the areas of fibrosis contained interspersed foci of polymorphonuclear cell infiltration. Many of the latter areas contained organism colonized in the form of granules that resembled those seen in actinomycosis. These organisms were gram-positive and branched, and measured close to 1 mum in diameter. Nocardia asteroides was isolated from the pulmonary tissue.

Animals↗
PubMed1976

Chromobacterium violaceum infection in a nonhuman primate (Macaca assamensis).

Chromobacteriosis caused by Chromobacterium violaceum was diagnosed as an Assam macaque, Macaca assamensis, that died 4 days after receipt of the Yerkes Primate Center, It was received from a primate facility in Florida where it has been housed with a group of rhesus monkeys for 5 years. The animal died suddenly without showing any signs of clinical illness. Necropsy findings included extensive hepatic necrosis with the formation of multiple large cavitary lesions. Foci of necrosis were also found in the lungs and lymph nodes. Numerous gram-negative bacilli were demonstrable in the lesions and Chromobacterium violaceum was isolated from the blood, liver, lungs, spleen and kidneys.

Animals↗
PubMed1975

Electron microscopy of albumin synthesis.

Albumin molecules appeared to be synthesized in the light hepatocytes of rats by bound polysomers on rough and endoplasmic reticulum and the nuclear envelope. The molecules were discharged directly into the cytosol, then to the external cellular spaces. This conclusion failed to support the current theory from biochemical studies that albumin is synthesized by bound ribosomes, discharged into the cisternae of rough endoplasmic reticulum, and transported to the smooth endoplasmic reticulum and then to the Golgi apparatus. In addition to the liver, positive syntheic activities were observed in the aorta, kidney, and hepatoma cells of rat. Earlier investigators have reported that only liver cells can synthesize albumin.

Albumins↗
PubMed1975

Disseminated oesophagostomiasis in the rhesus monkey.

Disseminated oesophagostomiasis was diagnosed at necropsy of 5 rhesus monkeys (Macaca mulatta). Nodular lesions were in visceral organs as well as in the colon and mesentery. Lesions varied greatly with respect to degree of organ involvement and damage due to parasite invasion. In 2 monkeys, nodular lesions were in the colon, mesentery, liver, kidneys, abdominal wall, urinary bladder, and uterus; in 1 of these 2 monkeys, a nodular lesion inhabited by a parasite was in a lung. The ectopic nodules in the less severely affected monkeys were scattered in the liver, kidneys, and abdominal wall.

Abdominal Muscles↗
PubMed1975

Limited form of Wegener's granulomatosis in ulcerative colitis.

The limited form of Wegener's granulomatosis is described as a complication in 2 cases of chronic ulcerative colitis. The coexistence of ulcerative colitis and the limited form of Wegener's granulomatosis raises the question of a common etiologic basis, possibly an immunologic defect. Awareness of such an association may help shed further light on the etiology of both disorders.

Adult↗
PubMed1975

The radiologic diagnosis of spontaneous mesenteric venous thrombosis.

Spontaneous mesenteric venous thrombosis is a distinct clinicopathologic entity that typically presents as abdominal pain of obscure origin. Pathologically, thrombosis of multiple small tributaries of the superior mesenteric vein causes segmental congestion, edema, hemorrhage and ultimately mucosal necrosis. Characteristic radiologic changes were found in 10 of 12 cases.

Contrast Media↗