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Biomedical subjects

J Castanet

Publications and source records attributed to J Castanet.

At least 55 records · Page 3Linked to original sources
PubMed1994

Juvenile pityriasis rubra pilaris associated with hypogammaglobulinaemia and furunculosis.

We report a case of follicular keratosis with inflammatory changes, consistent with a diagnosis of atypical juvenile pityriasis rubra pilaris. An unusual feature was the occurrence of severe Staphylococcus aureus folliculitis and furunculosis, a phenomenon rarely encountered in pityriasis rubra pilaris and the other follicular keratoses. Standard antibiotic and antiseptic treatment for chronic S. aureus infection was ineffective. The patient was subsequently found to have hypogammaglobulinaemia, and treatment with human polyvalent immunoglobulin infusions was successful in eradicating the sepsis. It is therefore probable that the hypogammaglobulinaemia played a pathogenic role in the development of cutaneous sepsis.

Adult↗
PubMed1994

Age estimation and longevity in reptiles.

After a brief recall of the classical meaning of the concept of longevity, the first part of this chapter describes and summarises the main current technique for the estimation of age in reptiles. Among them, sclerochronology is primarily taken into account. The cautious analysis of seasonal growth cycles recorded in hard tissues, although not as rigorous as the mark-release-recapture method of animals in their natural conditions, now appears as a rapid and reliable chronological tool already successfully used in individuals of many reptile species. Sclerochronology is especially efficient for the comparison of several populations, and it is the only method for fossils. The second part presents a synthetic review of known longevities and records in the different groups of reptiles. A short discussion about the significance of longevity shows that for reptiles, because of their thermic metabolism (ectothermy), the physiological longevity must be strongly distinguished from the chronological longevity, especially for a comparison with that known for birds and most mammals.

Aging↗
PubMed1994

Association of eosinophilic fasciitis, multiple morphea and antiphospholipid antibody.

The occurrence of morphea-like changes during the course of eosinophilic fasciitis is considered to be rare. We observed such a case with simultaneous occurrence of both types of lesions. Histologically, fibrosis and inflammatory infiltrate were seen in the entire dermis, the subcutis and the fascia, suggesting that the same process might account for all skin changes. In addition, our patient had an antiphospholipid antibody, neurologic symptoms and livedo-like cutaneous lesions. However, whether the antiphospholipid antibody played a pathogenic role or not remains unclear. Corticosteroid treatment was successful.

Aged↗
PubMed1994

Sclerodermatous changes revealing porphyria cutanea tarda.

We report a patient with sclerodermatous changes secondary to porphyria cutanea tarda, who responded to venesection treatment. The clinical characteristics of cutaneous sclerosis secondary to porphyria cutanea tarda and the degree to which it can mimic generalized morpheas are discussed.

Aged↗
PubMed1994

[Aseptic adenitis in pyoderma gangrenosum].

INTRODUCTION: Extra-cutaneous manifestations of neutrophilic dermatosis are rare. Symptomatic cases are usually multiform and confusing. We report a case with an aseptic lymph node abscess associated with pyoderma gangrenosum. CASE REPORT: A 28-year-old woman with past history of pyoderma gangrenosum was seen for abdominal symptoms and fever related to an epigastric mass. Due to signs indicating abscess formation, surgery was performed and led to total regression of the symptomatology. Recurrence was evidenced 3 months later with skin lesions which were negative on bacteriological examinations. The diagnosis of lymph node manifestations of pyoderma gangrenosum was retained. General corticotherapy was very effective. Relapse occurred again 6 years later and was treated with thalidomide. DISCUSSION: Lymph node involvement has been described in Sneddon-Wilkinson's disease associated with pyoderma gangrenosum. In neutrophilic dermatosis, pulmonary manifestations appear to be the least exceptional of the extra-cutaneous lesions. The pathophysiology has not been elucidated although recent hypotheses suggest that G-CSF could be involved. Corticotherapy is remarkably effective in most cases but thalidomide could be an interesting alternative treatment.

Abdominal Pain↗
PubMed1994

["Bronze baby" syndrome].

"Bronze baby" syndrome is a rare complication of phototherapy for neonatal jaundice occurring due to modified liver function, particularly cholestasis, of various origins. We report a case which occurred in a premature infant who developed a grey-brown coloration during phototherapy. The infant had haemolytic jaundice due to Rhesus incompatibility complicated by cholestasis of thick bile fluid. Abnormal accumulation of unexcreted photoproducts due to the cholestasis appeared to be the cause of the bronze coloration. The clinical course was favourable and the skin coloration returned to normal a few weeks after the end of the phototherapy. It is essential to identify the underlying liver disease in order to determine the prognosis of this syndrome.

Anemia, Hemolytic, Congenital↗
PubMed1994

[Pustular vasculitis disclosing Behçet disease].

INTRODUCTION: Pustular vasculitis is a classical manifestation of Behçet's disease. We report a case where the papulopustular eruption formed an arch on the skin and the histology examination showed predominant lymphocytic infiltration. CASE REPORT: A 29 year-old with a past history of recurrent buccal aphthosis had developed episodic papulopustular eruptions over the past 3 years. The diagnostic of Behçet's disease was made on the basis of an association with lymphocytic meningis, uveitis and erythema nodosum. General corticosteroid therapy was effective, but did not prevent skin relapse, controlled with colchicine. DISCUSSION: Pustular vasculitis usually presents with pustular eruptions on purpuric lesions and polynuclear infiltration of the dermis. Predominant lymphocytic infiltration is usually due to a pathergy phenomenon and would be specific for Behçet's disease. In our patient, colchicine was effective, although the mechanism remains to be explained.

Adult↗
PubMed1993

Paraneoplastic Raynaud's phenomenon.

A testicular tumour could be diagnosed by the occurrence of a Raynaud's phenomenon complicated by severe digital arteritis. The arteritis rapidly regressed under prostacyclin therapy. Such vascular manifestations are frequent in testicular carcinoma, but they usually develop after chemotherapy. To our knowledge, this is the first case where they preceded the diagnosis and specific treatment of a tumour of the testis.

Adolescent↗
PubMed1993

Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.

We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.

Aged↗
PubMed1993

Cutaneous leukocytoclastic vasculitis and renal cancer: two cases.

We report two cases of cutaneous leukocytoclastic vasculitis (CLV) leading to the discovery of an as yet asymptomatic, surgically curable clear cell carcinoma of the kidney. CLV causative factors or associated diseases are usually drugs, infection, or collagen vascular disease, but rarely malignancies. In such cases, these are more often malignant hematologic diseases than solid neoplasms. We believe that in apparently idiopathic CLV, a screening examination should be done to detect any underlying early-stage curable solid malignancy.

Adenocarcinoma↗
PubMed1993

Neutrophilic dermatosis associated with chronic neutrophilic leukemia.

Chronic neutrophilic leukemia is an uncommon myeloproliferative disorder. We report a new case that fulfills the clinical and biologic criteria for such a diagnosis. The hematologic disease was revealed by a neutrophilic dermatosis that finally disappeared spontaneously after a duration of 1 year. Despite the lack of parallelism in the course of dermatologic and hematologic manifestations, we believe they were strongly linked. Occurrence of neutrophilic dermatoses in the course of other myeloproliferative disorders is well known. However, in our case, clinical and histologic features could not be used to distinguish between atypical Sweet's syndrome and specific cutaneous lesions because of the mature appearance of both skin and blood neutrophils.

Aged↗