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Biomedical subjects

J Castanet

Publications and source records attributed to J Castanet.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Cutaneo-mucous manifestations of dengue].

OBJECTIVES: To describe muco-cutaneous manifestations of dengue fever, assessing their incidence and histopathological aspects. PATIENTS AND METHODS: During a dengue 2 epidemic, occurring in Guadeloupe in 1994, all patients admitted with a confirmed diagnostic of dengue fever were assessed for dermatological changes by 2 clinicians; 5 patients underwent skin biopsy with immuno-fluorescence staining. RESULTS: Among 39 adult inpatients (Sex ratio 1.1, medium age 41 years) none presented a severe form of the disease, whereas 18/39 (46 p. 100) had some muco-cutaneous changes, associating rash (13 cases (33 p. 100)), mucous membranes involvement (7 cases (18 p. 100)), or minor haemorrhages (6 cases (15 p. 100)). The rash appeared macular, discrete, itching, troncular with peripheral extension, rather than maculo-papular (morbiliform) as usually described. Apart from cases which minor haemorrhagic changes, significatively associated with marked thrombocytopenia (medium 37 x 10(9)/1), dengue cases either with or without muco-cutaneous changes had similar clinical (duration, severity) or biological (neutro-lympho-thrombocytopenia, transaminases) features, and evolution. Histological changes appeared non specific (minor lymphocytic dermal vasculitis, non contributive immuno-fluorescence). DISCUSSION: Clinical and histological features of the rash are unspecific and inconstant: they do not allow an easy and accurate diagnosis. Complete clinical, epidemiological (very recent travel in endemic areas) or biological data should be collected, and early virological or later serological confirmation is needed. As well as travel facilities are growing, the dengue area is extending: dengue fever should therefore be considered in every traveller with fever and rash.

Adolescent↗
PubMed1997

[Chronic edema, monoclonal dysglobulinemia and profuse telangiectasia: a distinct entity?].

INTRODUCTION: Monoclonal gammopathy and edema are features encountered during several diseases, especially systemic capillary leak syndrome. The diagnoses of POEMS syndrome, edematous systemic scleroderma and a fortuitous association may be also discussed. We report the cases of two patients which did not fulfill the criteria for such diagnoses. CASE REPORT: Although the 2 cases share some discrepancies, they have also similar and particular features: association of chronic edema, monoclonal gammopathy and profuse and acquired telangiectasias. DISCUSSION: The meaning of these cases remains to be clarified. It might be an entity close to the systemic capillary leak syndrome but characterized by the chronicity of edema and by a distinct cutaneous sign, the occurrence of numerous telangiectasias. These cases emphasize that the acquired and profuse telangiectasias belong to the wide range of cutaneous abnormalities which may be associated with monoclonal paraproteinemia.

Capillary Leak Syndrome↗
PubMed1996

Chronic varicella presenting as disseminated pinpoint-sized papules in a man infected with the human immunodeficiency virus.

A 39-year-old HIV-infected man had manifested a typical varicella successfully treated with intravenous acyclovir. Despite oral acyclovir, he developed 10 days later a widespread eruption of pinpoint-sized erythematous papular lesions. Histologic examination and viral culture showed a persistent varicella-zoster virus (VZV) infection. Intravenous acyclovir and foscarnet were both efficient. However, each withdrawal of intravenously administered treatment resulted in a rapid relapse. Among the atypical forms of chronic varicella, this eruption appears to be unique. As in our case, chronic VZV infection appears often to be a difficult therapeutic challenge.

AIDS-Related Opportunistic Infections↗
PubMed1996

[White papulosis of the neck. Clinical aspects of pseudoxanthoma elasticum].

INTRODUCTION: Acquired elastolysis of the papillary dermis simulating pseudoxanthoma elasticum and white papulosis of the neck are two skin diseases with clearly limited borders. The two entities can be distinguished clinically when papulae converge into yellowish-white patches and histologically by complete absence of the elastic network in the papillary dermis without thickening of the collagen network in the superficial and mid dermis. CASE REPORT: We observed a patient with the clinical and histological criteria for acquired elastolysis of the papillary dermis. Histological examination showed a thick collagen network as described in white papulosis of the neck. DISCUSSION: This case clearly demonstrates the histological continuum between these two entities. A review of the literature also provided evidence of borderline forms, leading us to propose grouping them together. Elastolysis of the papillary dermis would appear to be a relatively specific histological sign differentiating white papulosis of the neck, in a general sense, and acquired elastosis of the mid dermis. Two factors could explain the rare observations of acquired elastosis of the mid dermis in patients with acquired elastosis of the papillary derma: use of the Verhoeff Van Gieson stain without an internal control and imprecise localization of the biopsy.

Aged↗
PubMed1996

[Expression of growth dynamic in the structure of periosteal bone in Anas platyrhynchos].

An experimental study of the periosteal bone growth in the mallard from 42 to 154 post hatching days shows: (1) a noticeable time difference in the local biological age of the diaphyseal cortices between various long bones; (2) great differences in their histological structures, at a given individual age, expressing commensurate differences in local growth rates. Those results emphasize the importance of local factors to interpret the typology of the primary (periosteal) bone tissues. Experimental results allow to quantify the relationships between bone tissue typology and the velocity of its radial deposition.

Animals↗
PubMed1995

Subacute cutaneous lupus erythematosus associated with Hodgkin's disease.

Simultaneous occurrence of subacute cutaneous lupus erythematosus and malignancy has rarely been reported. We report the first case of subacute cutaneous lupus erythematosus associated with Hodgkin's disease. Although our case does not fulfill the criteria of paraneoplastic process, a relationship between the two disorders might be suggested by their simultaneous occurrence and in view of the cases of disseminated lupus erythematosus associated with lymphoma reported so far. The different hypotheses are discussed.

Hodgkin Disease↗
PubMed1995

[Alternaria tenuissima plurifocal cutaneous infection].

INTRODUCTION: Multiple skin localization of phaeohyphomycoses are rare and are encountered in immunodepressed subjects. We report a case due to Alternaria tenuissima in a patient given corticosteroids and IgA deficiency. CASE REPORT: A 73-year-old man presented with ulceronecrotic lesions on the two lower limbs which had developed over 15 days and poor general health. He had been taking corticosteroids for retroperitoneal fibrosis for 15 days. Skin biopsies demonstrated monoclonal dysglobulinaemia with IgG kappa and IgA deficiency. Itraconazol treatment was successful. DISCUSSION: Identification of Alternaria is in a skin sample, it not sufficient to determine its pathogenic nature. Strict criteria, especially histological criteria, are required. Most cases of cutaneous alternariosis are localized infections due to direct inoculation. They are seen in healthy patients or more often in immunodepressed subjects. Disseminated skin disease is rare and has been reported in 2 highly immunodepressed patients. Our patient was taking corticosteroids, but his deficiency state in IgA may have played a role in the development of the mycosis. Itraconazol appears to be effective treatment.

Aged↗