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Biomedical subjects

J C Weber

Publications and source records attributed to J C Weber.

At least 73 records · Page 4Linked to original sources
PubMed1987

Can embolic stroke be diagnosed on the basis of neurologic clinical criteria?

Diagnosis of embolic stroke is based on identification of a source of embolus (SOE) and on neurologic symptoms acknowledged as "clinical criteria." To test the validity of these criteria, we analyzed the symptoms at onset in 193 patients hospitalized after acute cerebral infarction. Patients were grouped according to identification of a cardiac SOE (106 patients), an arterial SOE (38 patients), or no SOE (49 patients). Cross-tabulations demonstrated that only rapidity and loss of consciousness at onset were associated with the presence of a cardiac SOE to a significant degree. Although these symptoms were highly specific for cardiac SOE, they were not sensitive. A distinct clinical neurologic profile from the symptoms and mode of onset was not identified.

Adult↗
PubMed1985

Visual function and academic performance.

Evaluation of 1,910 first-, second-, and third-grade students indicated that visual function and academic performance as measured by reading were not positively related. Visual function tests included visual acuity, muscle balance, preferred eye and hand, color vision, refraction, sensory and motor function, and a writing and drawing task. Academic tests included the Metropolitan Readiness Test, the Cognitive Abilities Test, the Iowa Test of Basic Skills, and the teacher's assessment of reading level. A simple test which can be completed during the office visit and interpreted by the ophthalmologist in the office included drawing, copying, and writing. A segment of this test, the "draw a bicycle test," can be used by an ophthalmologist to demonstrate the difference between vision and performance when examining a child up to third-grade level who is referred because of school failure.

Accommodation, Ocular↗
PubMed1984

The macula in ocular toxoplasmosis.

Of 60 attacks of ocular toxoplasmosis, in 37 (62%) no apparent macular problems were demonstrated on inspection, in seven (12%) active retinitis was evident within 5 degrees of the umbo, and in seven (12%) some evidence was shown of mild macular edema; severe edema, such as cystoid macular edema, was uncommon.

Anterior Chamber↗
PubMed1984

Maternal drug histories and central nervous system anomalies.

Prescription data for the three months before the last menstrual period and for the first trimester of pregnancy were obtained for 764 mothers whose children had a defect of the central nervous system and for an equal number of mothers of control babies born from the same doctors' practices. There was a statistically significant difference overall between the numbers of mothers who were prescribed drugs in the study and control groups during the trimester before the last menstrual period but no such difference was found for the first pregnancy trimester, nor was there a significant difference for any specific group of drugs. For a composite group of non-steroid anti-inflammatory drugs, salicylates, and sulphasalazine there was a significant difference for the trimester before the last menstrual period. There are arguments against such an artificial grouping, however, and when the individual drugs were considered the comparisons were no longer significant. The odds ratios for all medicines containing folic acid taken in the trimester before the last menstrual period were considerably less than unity, in contrast with nearly all other comparisons. This supports a suggested protective effect against neural tube defects of folic acid supplements begun before the onset of pregnancy but the odds ratios of these comparisons were not statistically significant.

Abnormalities, Drug-Induced↗
PubMed1983

Serum immunoglobulins and uveitis.

Sixty-two percent of 975 uveitis patients had a statistically significant elevation in the levels of one or more of three serum immunoglobulins. The percentage of cases of above-normal values was greatest for IgM (43.8%), followed by IgA (34.0%), and then by IgG (11.9%). There was no statistically significant difference in immunoglobulin values obtained for one diagnosis as compared with all others, except for men with HLA-B27. They had a higher percent of elevated IgM values than men with all other diagnoses. Testing for immunoglobulins is of little or no value in the etiologic diagnosis of a single case of uveitis, but may be of value in research studies to better understand its pathogenesis.

Female↗
PubMed1983

Surgical treatment of congenital esotropia.

We conducted a retrospective study of 133 children (69 boys and 64 girls) who underwent bilateral medial rectus muscle recession (most by the augmented or en-bloc technique) for congenital esotropia. Esotropia was diagnosed before the age of 6 months in 84 patients and after the age of 6 months in the other 49. A total of 27 children underwent surgery before the age of 12 months; of these, three required second procedures. A total of 106 children underwent surgery after the age of 12 months; of these, eight required second procedures. The mean preoperative deviation was 40 prism diopters. Two patients had significant A pattern deviations and 17 had significant V pattern deviations. Six patients had dissociated vertical deviations. Five to 60 days after surgery, 52 patients had no deviation and 99 were within +/- 10 prism diopters of no deviation. Two months after surgery, 67 patients had no deviation and 114 were within +/- 10 prism diopters of no deviation. Final alignments (five months to seven years postoperatively) showed that 51 patients had no deviation and 109 were within +/- 10 prism diopters of no deviation. Despite adequate alignment, none of 13 patients whose esotropia was diagnosed before the age of 6 months, who underwent surgery before the age of 12 months, and who cooperated with testing achieved stereopsis. This suggested that there may be two types of congenital esotropia--one without fusion potential and one in which fusion is possible but lost secondarily because of peripheral esotropic factors.

Child, Preschool↗
PubMed1982

Thyroid dysfunction and uveitis.

In 544 patients with uveitis, those with presumptive diagnoses of toxoplasmosis, tuberculosis, sarcoidosis, toxocariasis, and "unknown" had significant hypothyroidism (defined as a thyroxine level below 5.3 microgram/dL). Those with diagnoses of histoplasmosis, syphilis, rheumatoid arthritis, Fuchs'heterochromic iridocyclitis, serpiginious choroiditis, or HLA B27 did not have such low levels. No diagnostic entities showed significant hyperthyroidism (defined as a thyroxine level of 12.0 microgram/dL or more). All results were based on thyroxine levels; further studies should employ more modern techniques.

Humans↗
PubMed1981

[Recognition and management of perforation of the gastro-intestinal tract during endoscopy (author's transl)].

In the course of 71/2 years there occurred 37 cases of perforation of the gastro-intestinal tract after endoscopic investigation or operation in the abdominal region. Analysis of the therapeutic results indicates that immediate laparotomy in case of confirmed perforation provides the best survival chance. In individual cases with pneumoperitoneum and no symptoms careful supervision in a surgical intensive care unit before surgical intervention can be justified.

Aged↗