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Biomedical subjects

J C Moreno

Publications and source records attributed to J C Moreno.

At least 37 records · Page 2Linked to original sources
PubMed1999

Hydroxyurea-induced leg ulcers: is macroerythrocytosis a pathogenic factor?

Hydroxyurea is a common cancer chemotherapy agent that inhibits ribonucleotide reductase, an enzyme essential to DNA synthesis. It is considered the drug of choice in the treatment of chronic myelogenous leukemia and essential thrombocythemia. The occurrence of leg ulcers have been described in 8.5% of patients receiving continuous treatment with hydroxyurea, but the cause of this complication is unknown. We report two additional patients and suggest that macroerythrocytosis, which occurs in almost all the patients taking hydroxyurea, may be a pathogenic factor. Macroerythrocytosis can be considered as an 'acquired' blood dyscrasia, and similar leg ulcers have long been known to occur with certain hereditary blood dyscrasias, such as sickle cell anemia, thalasemia, and spherocytosis.

Animals↗
PubMed1999

Malignant fibrous histiocytoma of the scalp. Multidisciplinary treatment.

BACKGROUND: Malignant fibrous histiocytomas (MFH) are uncommon in the skin, and even less frequent on the scalp. On the scalp they are often very difficult to excise and it is even more difficult to close the resulting wound. OBJECTIVE: To review all malignant fibrous histiocytomas diagnosed and treated in our Department during the past 6 years, and to describe the multidisciplinary procedure employed to treat one special case of aggressive malignant fibrous histiocytoma on the scalp that recurred twice. RESULT: Malignant fibrous histiocytomas represent 0.01% of malignant cutaneous tumors in our area. The immediate results after a multidisciplinary treatment performed on a recurrent malignant fibrous histiocytoma located on the scalp were excellent, but recurrence was observed 6 months later. Two years later we have also treated another case of MFH on the scalp. The same surgical technique was performed, but the patient received high-dose-methotrexate-based neoadjuvant chemotherapy (HD-MTX). One year later, this patient is still alive and no signs of recurrence have been detected. CONCLUSION: When malignant fibrous histiocytoma occurs on the scalp it must be treated immediately by means of an excision with a large peripheral edge of 2 cm from the visual or CAT limits of the lesion, since the first treatment must be definitive.

Adult↗
PubMed1997

Fiddler's neck.

The dermatologic pathological condition of musicians is a rare medical problem. We would like to draw attention to what is called "Fiddler's neck," a process that is peculiar to violin, viola, or cello players and that may be caused by two different mechanisms: contact allergic reaction or a mechanical action.

Adult↗
PubMed1997

Cryosurgical treatment of professional chronic radiodermatitis.

BACKGROUND: Chronic x-ray dermatitis in professionals is a frequent problem for doctors in our country due to the fact that many of them widely used radiotherapy without any protection 15-20 years ago. Surgery has been the most accepted treatment, though it generally decreases hand function. OBJECTIVE: Up to now, cryosurgery was not usually considered as a possible treatment if the lesions were located on fingers. In this study, the advantages of cryosurgery for the treatment of professional chronic radiodermatitis with incipient pretumoral lesions are emphasized. METHODS: Cryosurgery was performed on six patients affected with chronic professional radiodermatitis that showed keratomas and ulcerations, using both spray (keratomas) and a probe 0.5 cm in diameter (ulcerations, in situ squamous cell carcinoma). Nerve block anesthesia with mepivacaine 1% was used in all cases. Before the treatment, all suspected lesions were biopsied; if invasive squamous cell carcinoma was revealed in the dermatopathological study, the patient was rejected. Variables such as blister and necrosis formation, pain, and achromatic, sensibility, and mobility disorders were studied. The follow-up period was 2 years. RESULTS: Immediate postoperative results showed great pain and blistering in all cases. Residual achromias were observed early postoperatively in all cases, but were repigmented 1 year after therapy in four cases (66%). Sensory alterations (hypo- and hyperthesias) were found in four cases (66%) 1 month after treatment, although this complication was not observed 6 months after treatment. Finger mobility was perfect in all cases 2 months after treatment, and there was no recurrence in any case after 2 years of follow-up. CONCLUSIONS: We believe cryosurgery must be considered as an excellent treatment for professional chronic radiodermatitis with keratomas, ulcerations, and incipient squamous cell carcinomas. Its use may prevent further dramatic surgical treatment, like amputations, allowing the preservation of finger function.

Aged↗
PubMed1997

Mesenteric arteriovenous differences in glucose, lactate and insulin concentrations in rats and humans.

The present study was aimed to investigate the mesenteric arteriovenous differences in blood glucose and lactate and plasma insulin in humans (n=8) and rats (n=10). Arterial (abdominal aorta) and mesenteric vein blood glucose and lactate (enzymatic methods) and plasma insulin concentrations (radioimmunoassay) were measured in patients during abdominal surgery and in normal rats. Blood glucose levels were significantly (p < 0.05) higher in the abdominal aorta than in the mesenteric vein in both rats (9.2+/-1.0 vs 7.5+/-0.8 mmol/l) and humans (10.4+/-2.9 vs 8.5+/-2.7 mmol/l). Blood lactate levels were higher (p < 0.05) in the mesenteric vein in both rats (3.7+/-1.3 vs 2.8+/-0.9 mmol/l) and humans (0.7+/-0.23 vs 0.1+/-0.05 mmol/l). Plasma insulin concentrations were identical in the aorta or mesenteric vein in both rats (314.4+/-162.0 vs 311.4+/-94.2 pmol/l) and humans (62.4+/-43.2 vs 61.8+/-48.0 pmol/l). In conclusion, both rat and human intestine retained a high proportion of arterially administered glucose and released lactate under the studied conditions.

Adult↗
PubMed1996

Cellular blue nevus with massive regional lymph node metastases.

BACKGROUND: Small, well-differentiated groups of nevus cells have been found occasionally in the marginal sinuses and parenchyma of regional lymph nodes that drain sites of cellular blue nevi. OBJECTIVE: The histologic, immunohistochemical, and karyometric description of a pigmented cutaneous lesion, with the features of cellular blue nevus and located on the leg of a 14-year-old woman, that was accompanied by synchronic presentation of massive inguinal lymph-node metastases. METHODS: The excised specimens were processed routinely, embedded in paraffin, and sectioned into 4-microm-thick slices. The sections were stained using hematoxylin-eosin and the ABC immunohistochemical method for demonstrating S-100 and HMB-45. Karyometric analysis was performed in a static cytometer using Feulgen-stained sections. RESULTS: The cutaneous lesion had the cytologic and architectural features of cellular blue nevus. The lymph nodes showed massive invasion by pigmented cells and contained extensive necrotic foci. After 3.5 years of clinical follow-up, the patient is free from disease. CONCLUSIONS: The absence of malignant features in the cutaneous lesion and the bland nuclear features of the pigmented cells in the regional lymph node metastases suggest that this case could be interpreted as an unusual form of benign cellular blue nevus with metastases. Nonetheless, other possibilities, such as malignant melanoma mimicking a cellular blue nevus or primary malignant melanoma of the lymph nodes with concomitant cutaneous cellular blue nevus, cannot be definitively excluded. A conservative surgical approach with close follow-up was recommended.

Adolescent↗
PubMed1995

Experimental streptozotocin-reduced diabetes and intestinal glucose metabolism in the rat, in vivo and in vitro.

The intestine has a high glycolytic activity, but its metabolic role could be altered in diabetes mellitus. The aim of the present work was to investigate in vivo the glucose retained and the lactate produced by the intestine of normal and diabetic rats and in vitro the effect of different arterial glucose concentrations on glucose utilization and lactate, alanine, and pyruvate production in normal and diabetic rats when the glucose is supplied to the intestine exclusively via the vascular route. In vivo, the normal and diabetic rats retained similar percentages of the arterially supplied glucose (14.7 +/- 2.4, respectively). In vitro, when the preparations were perfused under hyperglycemic conditions, the glucose consumed, as a fraction of the quantity infused, was significantly lower (P < 0.05) in the diabetic (247.0 +/- 22.8 mumol/mmol infused glucose) than in normal (315 +/- 16.3 mumol/mmol infused glucose rats) rats. The lactate produced was significantly higher in diabetic than in normal rats whether the preparations were perfused under isoglycemic (P < 0.01; 1916.4 +/- 124.0 vs vs 1284 +/- 67.7 mumol/mmol consumed glucose) or hyperglycemic (P < 0.05; 1356.4 +/- 199.7 vs 898.0 +/- 87.3 mumol/mmol consumed glucose) conditions. There was significantly (P < 0.05) greater alanine release from the diabetic (123.7 +/- 21.8 mumol/mmol consumed glucose) than from the normal (40.7 +/- 10.3 mumol/mmol consumed glucose) rat preparations perfused under isoglycemic conditions.

Alanine↗
PubMed1992

Total upper lip reconstruction with bilateral fan flaps.

Reconstruction of the total upper lip may be easily performed using fan flaps. However, two details must be taken into consideration: 1) the wide pedicle in the commissural angle, including the facial artery, must be designed, and 2) the mucosal flap must be 8 mm longer, in the inner portions, than the skin flap used to reconstruct the lip semimucosa.

Carcinoma, Squamous Cell↗
PubMed1992

[Tinea faciei: epidemiology].

Because of its clinical peculiarities responsible for many diagnostic errors resulting in potentially toxic treatments, tinea faciei should be regarded as a process with a personality of its own. The authors have reviewed 46 cases of tinea faciei, evaluating and highlighting their clinical and epidemiological peculiarities. As regards age and sex, two peaks of maximum incidence can be found: one in childhood, the other in adults older than forty. Many lesions progress over more than 12 months before they are diagnosed. Their peculiar clinical features suggests various initial diagnoses, the most frequent of which are related to photosensitivity (lupus erythematosus, polymorphous light eruption). Among the most frequently isolated dermatophytes, T. mentagrophytes var. granulosa and T. rubrum are outstanding.

Adolescent↗
PubMed1987

International dermatosurgery: reconstructive treatment of the vulva--a new procedure: experience on 23 cases over 4 years.

The postvulvectomy reconstruction caused the authors diverse problems in the first three operations. The use of a bipedicle advancement flap obtained from the anterointernal region of the thigh, modified depending on the extension of the vulvectomy and the elasticity of the skin allow us to suggest the use of this technique due to its safeness, the facility with which it is carried out, and reduction of the hospital stay, as this makes the method socially economical.

Atrophy↗
PubMed1986

Wegener's granulomatosis in two sisters.

We describe two sisters with necrotising granulomas. The intervals between the onset of symptoms and diagnosis were eight and nine years. The pathological findings showed necrotising granulomas in both patients, this being consistent with a diagnosis of pathergic (Wegener's) granulomatosis. The one patient that accepted treatment responded well to cyclophosphamide, though the facial lesions responded only to radiation therapy. Since the second was almost asymptomatic we conclude that relatives of patients with Wegener's disease should be investigated.

Adult↗