Search PubMed⌕ Search

Biomedical subjects

J C Jones

Publications and source records attributed to J C Jones.

At least 163 records · Page 9Linked to original sources
PubMed1981

Adjuvant therapy of stage II breast cancer: 48-month follow-up of a prospective randomized clinical trial.

A prospective, randomized clinical trial of adjuvant treatment of 318 stage II breast cancer patients, using chemotherapy, the antiestrogen tamoxifen, and immunotherapy is reported at 48 months follow-up. Women whose primary tumors have no estrogen receptors fall into a significantly poorer prognostic group than those whose tumors contain estrogen receptors. None of the adjuvant regimens appeared to offer any clear-cut advantage for the estrogen receptor negative patients. Those women whose primary tumor contains estrogen receptors appear to be in a prognostically favorable group, when their treatment regimen included the antiestrogen, tamoxifen. The adjuvant use of BCG immunotherapy does not appear to offer additional benefit, but the follow-up period of these treated patients is too brief to be conclusive. A longer period of observation is needed to determine whether this systemic treatment in estrogen receptor positive patients is preventing recurrence or merely delaying it.

Antineoplastic Agents↗
PubMed1981

Interference by polar metabolites in a direct radioimmunoassay for plasma aldosterone.

The CIS Aldoctk-125 kit, a direct radioimmunoassay for plasma aldosterone, has been compared with a conventional technique involving solvent extraction. Results given by these two methods were poorly correlated (r = 0.445, n = 103), the direct assay giving higher values, particularly in patients being dialysed for renal failure. When the kit was modified to include an extraction step, results correlated well with those of the standard method (r = 0.952, n = 60). These observations suggested interference form polar metabolites. The possibility that glucuronides were responsible was investigated by measuring plasma aldosterone before and after hydrolysis with beta-glucuronidase. Higher post-hydrolysis values confirmed the presence of glucuronides in plasma from normal subjects and patients with renal failure. Preliminary chromatographic studies on plasma form nine dialysis patients indicated the presence of tetrahydroaldosterone 3-glucuronide, and it is thought that this metabolite might contribute to the high values obtained with the direct assay.

Aldosterone↗
PubMed1981

Microtubule-organizing centres and assembly of the double-spiral microtubule pattern in certain heliozoan axonemes.

The double-spiral microtubule pattern is established by a self-linkage procedure when axopodial axonemes reassemble after cold treatment in multinucleate Echinosphaerium nucleofilum and mononucleate Actinophrys sol. Nuclei are related spatially to axoneme morphogenesis in both organisms but in rather different ways. Microtubules grow out in all directions from discrete clumps of dense material situated close to nuclei in E. nucleofilum as axonemal assembly begins. Each clump acts as a microtubule-organizing centre (MTOC) in so far as it is associated spatially with the assembly of microtubules for a single axoneme. The dense material spreads along the sides of a developing axoneme for several micrometers, where it probably promotes further microtubule assembly as the double-spiral pattern is established. Pattern is generated as microtubules that are randomly oriented to begin with become more closely juxtaposed and aligned with each other. There are indications that juxtaposition is brought about by the contractile action of a filamentous meshwork that interconnects the microtubules. Final positioning and alignment appears to be accomplished by a 'zippering' together of adjacent portions of microtubules that proceeds in both directions along the lengths of developing axonemes as self-linkage is effected. Considerable numbers of more or less radially oriented microtubules remain and project from the surface membrane of the single central nucleus during cold treatment of A. sol. Additional tubules assemble and become associated similarly with the nuclear envelope immediately after cold treatment. Initially these microtubules are not arranged in a double-spiral pattern, which is subsequently generated by procedures similar to those outlined above for E. nucleofilum. It is suggested that the surface of the nuclear envelope may act as an MTOC.

Animals↗
PubMed1980

Adjuvant chemotherapy, antiestrogen therapy and immunotherapy for stage II breast cancer: 45-month follow-up of a prospective, randomized clinical trial.

The results of adjuvant chemotherapy (CMF), endocrine therapy (t), and immunotherapy (BCG) in 318 women who had undergone mastectomy for Stage II breast cancer are reported after 45 months of life table analysis. CMFT therapy was found to be more effective than CMF alone in increasing recurrence-free survival. This beneficial effect appears to be limited to patients with estrogen receptor-positive tumors (ER+). Patients with estrogen receptor-negative tumors (ER-) (< 3 fmol/mg) have increased recurrence rates and higher mortality.

Antineoplastic Agents↗
PubMed1980

The renin--angiotensin--aldosterone system in the maintenance of blood pressure, aldosterone secretion and sodium balance in normotensive subjects.

1. Captopril given for 5 days caused a fall in blood pressure in normotensive subjects. The percentage fall in mean supine pressure was greatest on a low sodium diet (10 mmol/day), 19.6%, least on a high sodium diet (350 mmol/day), 11%, and in between on a normal sodium diet (120 mmol/day), 16.5%. 2. Captopril caused a marked fall in plasma aldosterone in normal subjects on all three sodium intakes. 3. Captopril caused an increase in sodium excretion on the normal (120 mmol/day) and low (10 mmol/day) sodium diet but not the high sodium diet. 4. These results suggest that the renin--angiotensin--aldosterone system is a normal mechanism for maintaining blood pressure and aldosterone secretion in normotensive man. The system may also be involved in the maintenance of sodium balance. 5. These results may lead to a better understanding of the role of the renin--angiotensin--aldosterone system in the maintenance or causation of high blood pressure in essential hypertension.

Adult↗
PubMed1980

Tuberous sclerosis presenting as chronic renal failure.

A patient with tuberous sclerosis presented with cutaneous lesions and chronic renal failure from multiple renal angiomyolipomas and diffuse rena cystic disease, but without apparent significant neurologic involvement. The clinical and pathologic features of tuberous sclerosis, as well as diagnostic and therapeutic procedures useful in this disorder, are reviewed with particular emphasis on the renal features of the disease.

Adolescent↗
PubMed1980

An in vitro study of marginal leakage associated with composite restorations using an acidified agar technique.

The marginal leakage associated with a composite restorative material was examined using an in vitro method for the production of secondary caries-like lesions after the restorations had been subjected to thermal cycling. The fillings were placed in cavities with a 90 degrees cavo-surface angle with and without etching of the walls with phosphoric acid and in cavities with a bevelled margin which were also acid etched. Some degree of leakage was demonstrated in 95% of the unetched cavities while approximately half of the restorations in etched unbevelled cavities showed leakage. With the bevelled and etched group virtually no leakage occurred.

Acids↗
PubMed1980

Granular cell tumor.

The case report presented herein involves a granular cell tumor of the vulva, an uncommon site, with unusual clinical characteristics.

Adult↗
PubMed1980

Antiestrogen, cytotoxic chemotherapy, and bacillus Calmette-Guerin vaccination in stage II breast cancer: a preliminary report.

A prospective, randomized clinical trial of three treatment regimens: (1) Cytoxan, methotrexate, and 5-fluorouracil (CMF), (2) CMF plus the antiestrogen drug, tamoxifen (CMFT), and (3) CMFT plus bacillus Calmette-Guerin (BCG) vaccinations in women with stage 22 breast cancer is reported. All patients underwent mastectomy and estrogen receptor (ER) analysis was performed. The results of this study show that patients with ER- tumors have recurrences more rapidly and have a higher mortality rate than patients with ER+ tumors (P less than 0.0001). In ER+ patients CMFT treatment is more effective in delaying recurrence than CMF alone at 33 months (P = 0.0176). This effect appears to be occurring in both premenopausal and postmenopausal women. In ER- patients the recurrence rate is high, and there is no significant difference among the three treatment groups. In premenopausal patients treated with CMF alone, however, ER- patients recur more rapidly than ER+ patients (P = 0.0313) and suggests that the effect of CMF may be related to the suppression of ovarian function. These findings have demonstrated a significant role for the use of antiestrogen therapy in patients with state II, ER+ breast cancer.

Actuarial Analysis↗
PubMed1979

Essential hypertension: effect of an oral inhibitor of angiotensin-converting enzyme.

Captopril, a specific oral inhibitor of angiotensin-converting enzyme, was given to 18 unselected patients with moderate essential hypertension. Mean blood pressure fell by 14.5% at the maximum dose given, and this fall was significantly correlated with the initial plasma renin activity. The main fall in blood pressure occurred two hours after the first dose of captopril. These results suggest that captopril effectively lowers blood pressure in patients with essential hypertension and that the renin-angiotensin aldosterone system may maintain blood pressure in essential hypertension. This does not necessarily imply that the renin-angiotensin system is the cause of the high blood pressure.

Adult↗
PubMed1979

Is "idiopathic" edema idiopathic?

Ten women with "idiopathic" edema had sodium and water retention and a rapid gain in weight when their accustomed intake of diuretics was suddenly stopped. The magnitude of these changes was directly related to the levels of plasma-rening activity before withdrawal of diuretics. Nine patients became edematous. Within 10 days of stopping diuretics, plasma-renin activity and urinary aldosterone excretion decreased to normal or below and within 20 days weight-gain and edema had subsided in seven patients. But the greatest gains in weight, in three patients, were sustained beyond 20 days. Nevertheless, a year later, two of these three patients were free of edema without the use of diuretics. Intermittent edema of unknown cause in most, if not all, otherwise healthy women seems to result from their use of diuretics, abetted in some patients by self-imposed flucuation of sodium and carbohydrate intake, and does not appear to be idiopathic.

Adult↗