Biomedical subjects
Publications and source records attributed to J C Jones.
An apparatus designed to study the growth rates of surface colonies in constant conditions, i.e. not affected by nutrient diffusion as in a closed Petri dish, is described. In contrast to classical experiments in closed systems, an exponential growth of colony radius is obtained for a period of more than 72 h. Nutrient concentration gradients are shown to be eliminated by analytical techniques.
The effect of feed alcohol in an apparatus designed to study growth rates of surface colonies in constant nutrient conditions was studied. The results obtained indicate that departure from exponential growth in normal conditions is due to accumulation of alcohol in the system.
The growth rates of yeast surface colonies under constant nutrient conditions were studied as a function of nutrient concentration. This was complementary to the initial experiment to measure the rates under such conditions, and to the investigation of the effects of alcohol. The possibility of fitting an equation of the Michaelis-Menten type to the variation of growth rate with carbon source concentration is considered.
The high alkalinity of the injection vehicle of certain parenteral solutions of acetazolamide produces necrosis of the skin upon sc injection. The possible modification of this effect on the teratogenicity of acetazolamide was examined. Acetazolamide in a vehicle of pH 10.5 produced 36.6% fetal malformations, in a vehicle of pH 8.7, 6.1%, and in neutral suspension, 11.8%. Adrenal medullectomy or phentolamine plus the high pH acetazolamide reduced the frequency to 23.2 and 24.4%, respectively. The teratogenicity of the low pH acetazolamide was increased by epinephrine to 64.2%. The frequency of hemimelia and micromelia, and of bilateral involvement, was greater in litters exposed to the high pH acetazolamide or the epinephrine-acetazolamide combinations, and was reduced by phentolamine or adrenal medullectomy. Neither the high pH vehicle nor epinephrine produced fetal defects in the absence of acetazolamide. The biological disposition of acetazolamide was not altered by any of the treatments. Reduction of uterine blood flow may be responsible for the potentiation of teratogenicity by the high pH vehicle.
A method to allow students to self-record manuscript letter strokes was applied to three groups of first-grade school children. These children learned to use plastic overlays in some 80 to 120 min, with agreement between students and experimenter concerning correctness averaging 79%, 82%, and 84% in the three groups. A practical method allowing children to record their letter writing, thus receiving immediate feedback appears to have been demonstrated.
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In this report, we shall review the clinical and pathological features of 64 patients who survived 10 years or longer after resection for bronchogenic carcinoma. Most of these patients had either adenocarcinoma or bronchioloalveolar carcinoma. None of them had oat cell carcinoma. In many of the long-term survivors, there were pathological findings generally considered to indicate a poor chance for survival. Thus we believe that curative resection for bronchogenic carcinoma should be attempted whenever feasible to offer the patient every hope of long-term survival.
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