Caroli's disease: case report and management recommendations.
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Biomedical subjects
Publications and source records attributed to J C Harvey.
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Eight-nine consecutive patients who were considered candidates for counterpulsation were reviewed for complications of the percutaneous intraaortic balloon pump (PIABP). Indications for counterpulsation were cardiogenic shock in 37 patients, refractory ischemia in 35, postcardiotomy shock in nine, acute infarction with threatened extension in four, septic shock in three and elective preoperative use in one patient. In 67 patients (75.3%), successful passage of the balloon was accomplished in a single attempt; the opposite-side attempt was successful in 10 patients (11.2%) and neither attempt was successful in 12 (13.5%). Seventy-seven patients who underwent PIABP had major complications, including limb ischemia in 12, bleeding at the puncture site in three, permanent foot drop in three, aortic dissection in three, renal embolism in one and false aneurysm at the puncture site in one. Fourteen patients had minor complications: asymptomatic loss of pedal pulses in eight, transient bacteremia in two, parasthesias in two and wound hematoma in two. No patient had free perforation, balloon rupture or wound infection. The rate and severity of complications of PIABP are similar to those with conventional IABP insertion. Ease of insertion alone should not be grounds for using PIABP in patients who can be managed without counterpulsation.
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During the interval from 1940 to 1970, 41 patients treated for primary operable carcinoma of the breast had subsequent pregnancies. Of 27 patients with axillary nodes negative for tumor, nine had first trimester abortions and 14 had pregnancies occur less than two years following mastectomy. Fourteen patients had axillary nodes positive for tumor, seven having first trimester abortions and eight pregnancies having occurred within two years of mastectomy. No detrimental effect of subsequent pregnancy could be demonstrated, even among patients with positive axillary nodes or among those whose pregnancies occurred less than two years following mastectomy. Abortion could not be demonstrated to improve the survival rate. We conclude that pregnancy need not be avoided or terminated among those patients who are apparently free of a recurrence after undergoing treatment for carcinoma of the breast.
The acute aspects of organophosphate poisoning are well understood. Persistent weakness and muscular wasting in some cases have been attributed to neuropathic effects resulting in muscular atrophy from denervation. Recently, necrosis of skeletal muscle has been induced by chronic inhibition of cholinesterase with organic phosphates in a reproducible experimental model. The literature on organophosphate poisoning in man alludes to cases in which it appears plausible to postulate this mechanism as a cause of a residual myopathy. A new case in which chronic organophosphate intoxication may be implicated in the etiology of a proximal myopathy is presented. Reports of additional cases, followed up from the onset of symptoms, are needed to determine whether primary myopathic effects are a clinically significant complication of chronic organophosphate poisoning.
Mesenteric desmoid tumors present difficult management problems among patients with Gardner's syndrome. Appearance of the problem is associated with prior abdominal surgery and with pregnancy. In the authors' experience, radical surgery alone has failed to control the disease and they recommend that it should be avoided when possible. Bypass procedures, interstitial implantation of radioactive materials, and chemotherapy represent alternatives which require further evaluation.
The prognosis of mucus-secreting adenocarcinoma of the trachea is grim. Its large size and infiltrative nature prohibit surgical resection and the response to radiation therapy has been poor. The authors report a case in which notable initial palliation was achieved through cobalt-60 therapy resulting in regression of the patient's tumour and a longer survival than that previously reported in patients with this disease.
Massive rectal bleeding may complicate Crohn's disease at any stage and tends to be persistent. Limited experience gained with this complication supports the use of selective agiography followed by conservative resection as the management of choice. Results of experimental studies suggest that selective infusion of vasopressors may be safely attempted when hemorrhage complicates Crohn's disease in its early stages but is probably too hazardous in cases in which the disease is more advanced.
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The results of repair of double outlet right ventricle in 26 children are reported. Eighteen of these patients had subaortic ventricular septal defect (VSD), without pulmonary stenosis (PS) in 5 and with PS in 13. Another 8 patients had subpulmonic VSD, without PS in 6 and with PS in 2. All had concordant atrioventricular relationships. There were six early deaths and two late deaths of the 26 patients in our study. Of these, 5 patients had severe associated cardiac abnormalities, and 2 who died early had had an incision in the systemic (right) ventricle.
The restless leg syndrome is characterized by unpleasant lower extremity nocturnal aching, muscle cramps, and restless shuffling. Although the cause remains unknown in the majority of cases, two instances are reported of the restless leg syndrome caused by peripheral cholesterol crystal microemboli. The syndrome caused by cholesterol microemboli and the syndromes of the restless leg are reviewed.
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Experiences in managing patients suffering cardiac stab wounds and coming to the University of Alabama Hospital in Birmingham from January 1964 to July 1972 are reviewed. From 1964 through July 1971, conservative management was used primarily, but most patients ultimately required operation. Analysis of our experiences during this period convinced us of the advisability of primary operative management for these patients, and since July 1971, primary operative management has been used. In the years from January 1964 to July 1972, 34 patients with cardiac stab wounds were treated at our hospital. Ten were managed conservatively with three deaths among this group. The remaining 24 received operative management either primarily or secondarily, and all of these patients survived. A patient managment program is outlined.
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