Biomedical subjects
J C Hart
Publications and source records attributed to J C Hart.
An epidemic of clam-associated hepatitis.
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Sagittal growth of the craniofacial complex in normal embryonic mice.
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Techno-legal factors in developing the radiation dose record.
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Changes in the hydroxyproline, hexosamine and sialic acid of the diabetic human and beta, beta'-iminodipropionitrile-treated rat retinal vascular systems.
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On the legalistic aspects of the radiation exposure record.
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The electroretinogram in multiple sclerosis and demyelinating optic neuritis.
The electroretinogram (ERG) to flashes of white light presented under photopic conditions and the pattern reversal visual evoked potentials (PR-VEPs) from both eyes were recorded from 14 patients with multiple sclerosis (MS) with monocular demyelinating optic neuritis (DON) and from 11 patients soon after presenting with monocular demyelinating optic neuritis alone. Fifteen and 10 normal subjects, matched for age and sex, were used as controls for each group of patients respectively. In the DON group of patients and controls the flicker following ERG (FF-ERG) to white flashes of light at 40 Hz was also recorded. Skin electrodes and averaging procedures were used for all the recordings. The PR-VEP elicited with stimulation of the affected eye was absent or abnormally delayed, and the amplitude of the 'b' wave of ERG of the affected eye was diminished in all patients. The 'b' wave latency, however, was similar in both affected and non-affected eyes and the controls. There was no difference in 'a' wave amplitude and latency between eyes of patients and normal subjects. The FF-ERG in 8 out of 10 patients with satisfactory recordings was diminished in the affected eye. These results provide neurophysiological evidence that retinal damage is not due to loss of myelin but is an early feature of demyelinating optic neuritis. This damage preferentially affects the retinal elements associated with the generation of the 'b' wave of the ERG, probably the glial cells of Müller.
Uniform safety of beating heart surgery using the octopus tissue stabilization system.
BACKGROUND AND PURPOSE: Minimally invasive coronary artery bypass grafting (CABG) has been facilitated by the introduction of the Octopus Tissue Stabilization system (OTS). OTS improves exposure immobilizing the heart with minimal hemodynamic effects allowing multivessels off cardiopulmonary bypass (CPB) CABG. The purpose of this study was to compare the utilization and clinical outcome of the OTS in three geographically distinct centers. METHODS: 239 patients who underwent OTS-CABG at Allegheny University Hospital/Medical College of Pennsylvania, Harrisburg Hospital, and Park Nicollet Clinic/HealthSystem Minnesota were reviewed. Age, acuity of patients, and number and type of vessels bypassed were recorded. Complications, mortality, length of hospital stay, incidence of conversion to CPB and blood transfusions, and operating room costs were compared to risk matched control patients who underwent CPB CABG during the same period. RESULTS: Results were similar in all three centers. The average age was 62.3 years. Emergent operation was necessary in 7%-10% of patients, the operations averaged 1.8 grafts/patient. Arteries bypassed were LAD, DIAG, OM, RCA, PDA, and RPLB. There were 96% of operations completed without CPB. Morbidity was low (12%). Atrial fibrillation and blood transfusion rate were decreased. Mortality was 0 compared with a predicted mortality of 1.6%. Hospital length of stay was shorter and operating room costs were 61% lower. CONCLUSIONS: OTS provides predictable reproducible immobilization allowing the performance of single and multiple off-pump CABG to almost all coronary branches with minimal morbidity and decreased costs in a variety of patients. Similar findings from three different centers suggests that these results are easily reproducible.
Multivessel off-pump coronary bypass with the Octopus experience in 226 patients.
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Effect of recipient lamellar keratectomy on corneal topography in penetrating keratoplasty.
Recipient tissue weakness is thought to be a cause of the high residual astigmatism that may follow penetrating keratoplasty (PK). In a rabbit model, we investigated the topographic effect of a controlled lamellar keratectomy (6 x 3 x 0.25 mm) on the recipient side following PK. Results from 10 animals indicate an overall flattening of 5 D along the axis of the keratectomy--i.e., the axis of recipient tissue weakness. Our results indicate that recipient corneal integrity may be a factor in corneal transplant topography.
Growth of the craniofacial complex during formation of the secondary palate.
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Effects of exogenous surfactant on neonates supported by extracorporeal membrane oxygenation.
OBJECTIVE: The purpose of this study was to evaluate the impact of exogenous surfactant on the duration of extracorporeal membrane oxygenation needed to support neonates. STUDY DESIGN: Retrospective case review. RESULTS: The duration of extracorporeal membrane oxygenation decreased from 112 +/- 43.3 hours to 76 +/- 17.9 hours. There was no difference in duration of mechanical ventilation, duration of supplemental oxygen, incidence of chronic lung disease, or length of hospital stay. CONCLUSION: Surfactant administered soon after initiation of extracorporeal membrane oxygenation results in a significant reduction in the duration of extracorporeal support for neonates.