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Biomedical subjects

J C Gerster

Publications and source records attributed to J C Gerster.

At least 127 records · Page 7Linked to original sources
PubMed1987

[Hereditary chondrocalcinosis in a Swiss family].

A Swiss family with hereditary articular chondrocalcinosis is described. Chondrocalcinosis was found on x-rays of five cases in two generations. In four there were recurrent attacks of pseudogout; in all observations the first rheumatic symptoms started early in the fourth decade. There was no history of consanguinity and the mode of inheritance was autosomal dominant, in agreement with most of the other familial pedigrees reported in the literature.

Adult↗
PubMed1987

Nonspecific inflammatory monoarthritis in the vicinity of bony metastases.

We describe a patient that presented with arthritis of a knee joint unresponsive to conventional treatment and who was found to have bony metastases of the distal femur from lung carcinoma. The presence of malignant cells could not be demonstrated in the synovial fluid or in the synovium. Our case illustrates the fact that malignant metastatic deposits in bone adjacent to a joint may cause a nonspecific synovial inflammation.

Arthritis↗
PubMed1986

[The place of apatite in rheumatic diseases. Study of 25 cases by x-ray microanalysis and scanning electron microscopy].

The importance of "apatite deposition disease" among the arthropathies has been recognized for some years: it is well known that X-ray microanalysis (XRMA) is an efficient method of determining the elemental constitution of microcrystalline deposits obtained from synovial fluids or from tendon washing solutions during examination in scanning electron microscopy. In all 25 patients studied (11 intraarticular and 14 extraarticular samples), alizarine red S staining was positive and XRMA confirmed the diagnosis of apatite deposition by determination of the phosphorus/calcium (P/Ca) ratio in the deposits. In the 25 patients the mean values obtained for the P/Ca ratios were situated between 0.362 and 0.450, with a general mean value of 0.411, i.e. a ratio clearly lower than the P/Ca ratio of pure hydroxyapatite specimens (0.438) measured in identical conditions. This apparent discrepancy seems to be related to the probable presence of carbonated apatites. The study confirmed the presence of apatite microcrystals in intra- and extraarticular location; in the first condition, these were generally found in patients with severe destructive arthrosis, whereas in the second condition the calcifications derived from supraspinatus tendons.

Adult↗
PubMed1986

[Algodystrophy].

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Humans↗
PubMed1986

Calcitonin and reflex sympathetic dystrophy syndrome.

Reflex sympathetic dystrophy syndrome is a difficult condition to treat. Many modalities have been proposed, all of them being clinically effective but whose efficacy is often difficult to assess, and has not been properly compared. A regimen of physical therapy (pressure therapy, antalgic electrotherapy and exercise therapy) with or without calcitonin was investigated in 24 patients randomly assigned to 2 groups, one given physical therapy alone (Group I) and the other physical therapy plus salmon calcitonin 100 MRC units daily for 3 weeks (Group II). Efficacy assessment was based on clinical (pain, oedema and movement in the affected parts), biochemical (blood and urinary phosphorus and calcium levels, plasma 25-OH-D, plasma parathyroid hormone (PTH), creatinin, alkaline phosphatases and urinary hydroxyproline) and scintigraphic parameters, as well as on the patient's ability to resume working. There was significant improvement in pain in the Group II patients after one week of treatment. As a result the authors advocate the use of calcitonin in addition to physical therapy in reflex sympathetic dystrophy syndrome - and even of calcitonin alone where physical therapy is not possible.

Adult↗