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Biomedical subjects

J C Gerster

Publications and source records attributed to J C Gerster.

At least 109 records · Page 6Linked to original sources
PubMed1990

[Destructive arthropathies].

Destructive arthropathies occur not only in septic arthritis and inflammatory rheumatism but also in degenerative joint disease. The destruction may be slowly progressive or conversely very fast, leading for instance to rapid destruction of the hip joint. Articular chondrocalcinosis and apatite deposition disease are often associated with destructive arthropathy. It is assumed that enzymatic release from leukocytes which have phagocytosed the crystals could play a major role. There is no clear cut evidence that clinical or intrasynovial use of corticosteroids or non steroidal antiinflammatory drugs is responsive for joint destruction. Interestingly, in chronic hemodialyzed patients destructive arthropaty can occur especially in the vertebral column. Amyloid of deposition of beta-2 microglobulin origin is considered as a causative factor.

Arthritis↗
PubMed1989

[Still's disease in adults: apropos of 6 cases].

We describe six cases of adult onset Still's disease diagnosed between 1981 and 1987. These cases are well representative of the different clinical and evolutive features of this disease. Two patients had visceral involvement, two suffered from destructive arthritis. The evolution was very variable and depended on the severity of articular and visceral involvement. More than 228 cases of adult Still's disease have been reported since Bywater's first description in 1971. We recall the clinical and biological signs of this disease and the diagnostical criteria recently proposed by Reginato.

Adult↗
PubMed1989

[Articular involvement in Swiss patients with a Borrelia burgdorferi infection--report of 8 cases].

Eight cases of Lyme's arthritis are reported. In four of them, they are related to an erythema chronicum migrans, in two to an acrodermatitis atrophicans. In two cases, there was no cutaneous manifestation, but the serology was strongly positive for Borrelia burgdorferi, and there was rapid relief of the pain with antibiotic therapy. It is suggested that Lyme's arthritis is not rare in Switzerland and that it must be searched for in every case of arthritis of unknown etiology, especially when there is a history of cutaneous involvement. The arthritis is cured by antibiotics.

Adolescent↗
PubMed1989

[Destructive arthropathies].

Destructive arthropathy occurs not only in septic arthritis and inflammatory rheumatism but also in osteo-arthrosis. The destruction may be slowly progressive or conversely very fast. Old age, female sex and local overload are contributing factors. There is no clear-cut evidence that the articular chondrocalcinosis and apatite deposits are associated with destructive arthropathy. Enzymatic release due to the phagocytosis of the microcrystals could be one of the causes of the destruction. There is no clear-cut evidence that the clinical use of intracorticosteroids or of non steroidal anti-inflammatory drugs is reasonable for destructive arthropathy.

Aged↗
PubMed1989

Osteoarthrosis and apatite synovitis. Pathological study of a metacarpophalangeal joint.

A case of metacarpophalangeal osteoarthrosis associated with synovial apatite deposits is reported. The size of the crystals indicates that they have been thickened by a recrystallization process; the latter could have been provoked by Ca and Po4 ions released by dissolution of some apatite crystals brought by calcified debris of bone or cartilage coming from the abraded osteoarthrotic surfaces. The role of such thickened crystals in synovial inflammation is discussed as well as their possible diagnostic value in determining origin and pathogenesis of a given synovial apatite deposit.

Apatites↗
PubMed1989

Upper limb pyrophosphate tenosynovitis outside the carpal tunnel.

Three cases of calcium pyrophosphate dihydrate (CPPD) crystal deposits in tendon sheaths outside the carpal tunnel are reported. Crystals were shown by x ray diffraction analysis in one case and by compensated light microscopy in the other two. Surgical excision of the tendon synovial sheath had to be done in two cases (one case with CPPD crystal deposits).

Aged↗
PubMed1989

[Fibrositis].

Explore the source record for details and available documents.

Adult↗
PubMed1989

Cervicooccipital hinge changes during longterm hemodialysis.

A radiological survey of the upper cervical spine was carried out in all our unit cases treated by longterm hemodialysis for at least 8 years. There were 23 patients, 16 men, 7 women, whose mean age was 56.5 years. Among them, 9 had radiological changes in the cervicooccipital hinge. Bone cysts of various sizes were found in the dens (5 times), in the body of C2 (3 times) in the lateral masses of C1 (5 times) and in the anterior arch of C1 (3 times). A pauci-symptomatic odontoid fracture was demonstrated in 1 case. Only 3 patients suffered from cervical pain. Although no biopsy was performed, it is suggested that the bone cavities could be due to local amyloid deposits. beta 2 microglobulin serum levels were considerably increased in all cases.

Adult↗
PubMed1989

[Rheumatic disorders and AIDS].

Various rheumatologic diseases were reported in patients infected by the HIV (human immunodeficiency virus); in most cases, they are related to Reiter's syndrome, reactive arthritis and opportunistic germs arthritis. Based on three cases we summarize the present knowledge in this field.

Acquired Immunodeficiency Syndrome↗
PubMed1988

[Low-dose oral methotrexate in the treatment of rheumatoid polyarthritis].

28 patients with severe rheumatoid arthritis were treated with pulse weekly oral methotrexate over a mean follow-up of 24 months (6-36 months). Within one month the patients improved significantly by all clinical standards of efficacy and erythrocyte sedimentation rate. Maximum improvement tended to occur after 6 months' therapy and was maintained for up to 36 months in most patients. 11 patients discontinued treatment because of adverse effects. It is concluded that this trial confirms the efficacy of methotrexate in rheumatoid arthritis. Careful baseline and follow-up monitoring is recommended due to frequent adverse reactions.

Adult↗
PubMed1988

Synovial fluid lactic acid in acute and chronic pyrophosphate arthropathy and in osteoarthritis.

A comparison of synovial fluid lactate levels has been made in cases of chronic pyrophosphate arthropathy (PA) with and without joint destruction, acute PA and osteoarthritis. No statistically significant difference could be observed between results of chronic PA and osteoarthritis. By contrast, synovial fluid lactate levels were significantly higher in acute PA in comparison with the two other groups. These data suggest that hypoxia is unlikely to play a role in destructive arthropathy commonly found in chronic PA.

Acute Disease↗