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J Buvat

Publications and source records attributed to J Buvat.

133 records · Page 8Linked to original sources
PubMedDate not supplied

[Hormonal profile in anorexia nervosa under control. Correlations with various somatic factors].

In order to precise the hormonal pattern of Anorexia Nervosa (AN) at its state phase, we assessed serum estradiol (E2), triiodothyronine (T3), LH and FSH, the maximum increments of their response to 100 microgram LHRH (delta LH and delta FSH) and the ratio of these increments (delta LH/delta FSH). These data were compared with those obtained in 10 normal women assessed at the early follicular phase (Student's test). Furthermore in 20 cases, we assessed LH and FSH during 5 days after a 20 mg IV injection of PREMARIN. E2, T3, LH and FSH are often decreased in AN. On the average, this decrease is very significant for the 3 first ones (p less than 0.001), and slightly significant for FSH (p less than 0,05). The LHRH-response is variable, with an inversion of the LH/FSH ratio as before the puberty in 56% of the cases. On the average, FSH-response is increased (p less than 0,05), and LH-response is normal. The response is delayed for the both gonadotropins. After PREMARIN, the 2 gonadotropins rarely clearly decrease (twice for LH and 5 times for FSH). There is a LH peak only in 3 cases. In order to specify the origin of these anomalies, we searched correlations between 11 hormonal data and some somatic parameters : weight, time, menstrual antecedents. We found 26 statistically significant correlations (12 times p less than 0,05- 5 times p less than 0,001- 9 times p less than 0,001). The following correlations are significant : E2 and LH, E2 and the maximal decrease of LH after PREMARIN (negative correlation), T3 and FSH, delta LH, and delta FSH, duration of the amenorrhea and T3, FSH and delta FSH, the weight and delta LH, the weight and delta LH/delta FSH, weight/height and delta LH/delta FSH, the menstrual antecedents and FSH. So, somatic factors strongly influence the hormonal pattern at the AN-state phase. The weight-decrease, the T3-decrease, and above all the E2-decrease which is independent of the previous ones seem to be the determining elements of the AN-hormonal pattern at this phase.

Adolescent↗
PubMedDate not supplied

[Basal prolactinaemia and responses to TRH and to sulpiride in different categories of male sexual dysfunctions (author's transl)].

We assayed serum prolactin (PRL) and serum testosterone (T) in 435 males complaining about a sexual dysfunction (SD) without any clinically detected etiology: erectile impotence (IMP): 320 cases distributed into 3 groups according to their semiology; anejaculation (ANEJ): 26 cases; premature ejaculation (EP): 75 cases; isolated lack of libido: 11 cases; isolated anorgasm: 3 cases. PRL-response to 200 micrograms of TRH was assessed in 41 cases, and PRL-response to sulpiride in 38 cases. We compared these results to those of 28 normal males with t test. Serum PRL exceeds 75 ng/ml in 3 IMP and 1 ANEJ, everyone presenting psychological disturbances. It is mildly increased (18 to 58 ng/ml) in 3,7% IMP and 17,3% EP and normal in the other cases. Mean PRL is lower in ANEJ and IMP than in normal males. PRL decrease is clearer in the group in which erection is the most disturbed. T is lower in ANEJ than in normal males, IMP and EP. Area under the curve of PRL-response to TRH is lower in ANEJ and IMP (for the groups with the most disturbed erection) than in normal males and EP. PRL-response to sulpiride doesn't differ from that of normal males in the 3 categories of SD. Research of linear correlations between scores of anxiety and depression and PRL maximal increments after TRH and sulpiride in EP and ANEJ is negative. So impotency and anejaculation may be the sole telltale sign of an hyperprolactinemia and PRL systematically must be assayed in these SD. But mild abnormalities probably are the witness of emotional disturbances which escort or cause SD and have no etiologic role.

Anxiety↗