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J Buvat

Publications and source records attributed to J Buvat.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Prolactin regulation in 14 cases of galactorrhea and hypogonadism with minimal modifications of the sella turcica (author's transl).

In this study we report 13 cases of amenorrhea-galactorrhea and one of a male patient complaining of gynecomastia, galactorrhea, sexual impotence and sterility with oligoasthénospermy. In these cases, the size of the sella turcica was normal but we found a localized depression of the bottom of the sella turcica; these modifications were situated at the antero-inferior part of the sella in 12 cases and posteriorly in the 2 others. Basal prolactin level was higher than normal values in 13 cases (12 female and 1 male patients): individual values varied between 45 and 367 ng/ml. Nycthermeral rhythm disappeared in the 9 cases studied. Administration of L-Dopa (500 mg orally) significantly suppressed the prolactin values in the 11 cases studied. Oral water loading (20 ml/kg) left prolactin values unchanged (10 cases). After oral glucose tolerance test (1 g/kg) no significant systematic variation occurred. The increase of prolactin values after stimulation by 200 microg. TRH IV as a bolus (4 cases) was not significant. We have found similar prolactin variations in cases of hyperprolactinemia with either normal pituitary fossa (7 cases) or macro-adenoma (6 cases).

Adenoma↗
PubMedDate not supplied

[Proceedings: Sulpiride effects on plasmatic gonadotropins in women (author's transl)].

The study of longitudinal evolution of plasmatic gonadotropins in women receiving sulpirid, a psychotropic drug with a strong anti-ovulatory effect, shows the coexistence of anovulation and the peristance of a physiological pattern of gonadotropins during the first cycle of treatment. It also shows the persistance of LH peaks comparable to preovulatory levels more than one year after the initiation of therapy. However, the basal line became very unsteady. This study suggests the presence of two types of perturbations with sulpirid. A hypothalamic-hypophyseal mild action and, an ovarian resistance to gonadotropins resulting from the hyperprolactinism induced by sulpirid.

Female↗
PubMedDate not supplied

[Physiopathogenesis of idiopathic hairy virilism. II. Sources and mechanisms of the increase of production of androgens in idiopathic hairy virilism].

The rise in the secretion of androgens appears in many cases (50 per cent of cases) of primary idiopathic hairy virilism to be mixed or exclusively ovarian which in turn excludes the adrenal (less than 10 per cent of cases) in the production of androstenedione and testosterone. The part that the adrenals play in hyperandrogenization seems to be the result of enzymic partial blocks which are more or less compensated for. Thus about half of cases of idiopathic hairy virilism are of mixed origin, although the role of the ovary is by and large predominant for testosterone, whether the ovaries are or are not macroscopically polycystic. Both overproduction of androgens and/or overproduction of oestrogens by the ovaries can be responsible for overfunctioning of the adrenals in an androgenic manner because of enzymic dysfunction. In some cases the reverse can be demonstrated but then the functional pathology is more obscure.

Androgens↗