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Biomedical subjects

J Bryant

Publications and source records attributed to J Bryant.

At least 163 records · Page 9Linked to original sources
PubMed1981

A pleomorphic lipoma in the scalp.

The pleomorphic lipoma is a benign neoplasm of lipocytes with atypical histologic features. The tumor shows a predilection for the region of the neck and shoulders of midde-aged and elderly men and must be differentiated from similar-appearing malignant entities such as liposarcoma and malignant myxoid fibrous histiocytoma. An occurrence of a pleomorphic lipoma in the scalp is reported and its histologic features described and discussed.

Humans↗
PubMed1981

Removal of the genome-linked protein of foot-and-mouth disease virus by rabbit reticulocyte lysate.

Rabbit reticulocyte lysate cleaves the genome-linked protein VPg from foot-and-mouth disease virus (FMDV) RNA. This activity could be reliably monitored since removal of the protein resulted in a change in migration in polyacrylamide gels of the small specific 5' and fragment of the RNA (S fragment). The unlinking activity cleaved the bond between the tyrosine residue of VPg and the RNA to leave a 5' phosphate on the RNA. The 5' sequence of the RNA from which VPg had been removed by rabbit reticulocyte lysate was the same as that of FMDV mRNA isolated from infected cells. VPg released from the RNA was rapidly degraded by the rabbit reticulocyte lysate to material which eluted with the inclusion volume of a Sepharose 6B column and partitioned to the aqueous phase during phenol extraction. The unlinking activity was inhibited by heating the lysate to 56 degrees C, by sodium dodecyl sulfate (SDS), EDTA, and Zn2+ ions but was unaffected by reducing agents, a translation inhibitor, and a number of protease and RNase inhibitors.

Animals↗
PubMed1981

Fatal case of cytomegalovirus pneumonitis in a postpartum woman.

This is the first reported fatal case of cytomegalic inclusion disease in a pregnant woman. The 28-year-old woman died after cesarean section for cephalopelvic disproportion. The diagnosis of cytomegalic inclusion disease was made at autopsy by finding enlarged pneumocytes with typical intranuclear inclusions, positive direct immunofluorescence on the lung tissue with antibody specific for cytomegalovirus, and retrospective serologic titers of 1:64 for the virus. The time of the infection is unclear, but the absence of infection in the newborn may suggest an onset late in pregnancy; there was no evidence of disease before labor and cesarean section.

Adult↗
PubMed1979

Senile confusion: assessment with a new stimulus recognition test.

There is a need for rapid and convenient assessment instruments to test the aged for senile confusion due to organic brain syndrome (OBS). The Mental Status Questionnaire (MSQ) and the Face-Hand Test (FHT) have certain limitations. A valid instrument must measure short-term memory loss and recognition. Sixty-two patients were examined in 17 different trials of the Stimulus Recognition Test (SRT), which involves 10 items. Each item classified the patients according to staff ratings (P less than .001), MSQ MSQ scores (P less than .005), and FHT scores (P less than .005). The composite MSQ score on a scale of 0--10 also served to separate the patients according to staff ratings (P less than .005). The SRT scores correlated .81 to .67 with the MSQ and FHT scores. The SRT does not show the same false positive patterns as the MSQ and FHT. For that reason, it constitutes a useful diagnostic supplement. Suggestions for further research are made.

Humans↗
PubMed1979

Classification of peste des petits ruminants virus as the fourth member of the genus Morbillivirus.

Peste des petits ruminants (PPR) is a virus disease of sheep and goats in West Africa. When first described, the virus was considered a variant of rinderpest virus. The biological and physicochemical characteristics of the virus indicate that it is closely related to measles, rinderpest and canine distemper viruses. These three viruses form the genus Morbillivirus of the Paramyxoviridae. PPR virus is sufficiently distinct from these 3 viruses to justify considering it as the fourth member of the Morbillivirus genus.

Animals↗
PubMed1978

Neoplastic behavior of chromosomally abnormal clones in New Zealand Black mice.

Old New Zealand Black (NZB) mice frequently develop reticulum-cell sarcoma and clones of aneuploid cells in their spleens. In order to define the relationship between neoplasms and chromosomal abnormalities, the pattern of distribution of aneuploid cells was studied to see if it corresponds to that expected of the malignancy, and chromosomally aberrant or normal spleen cells were transplanted into syngeneic newborn recipients. The results indicate that aneuploid cells arise focally but may disseminate widely in an affected mouse. A strong association was found between spleen-cell aneuploidy in a transplantation donor and both aneuploidy and histological evidence of reticulum-cell sarcoma in young recipients. Chromosomal aberrations in young recipients were always of donor origin. On the basis of these data, it seems likely that aneuploid clones which arise in the spleens of old NZB mice usually are at least potentially neoplastic.

Aneuploidy↗
PubMed1978

Hypochondriasis in an institutional geriatric population: construction of a scale (HSIG).

The staffs at three extended care facilities identified a group of 10 hypochondriacal patients. The research team asked these 10 patients and 59 controls, 27 questions relating to health attitudes and behaviors. Six items were found to be fairly useful in distinguishing hypochondriacal from non-hypochondriacal subjects. These six items were taken as the Hypochondriasis Scale for Institutional Geriatric Patients (HSIG), and each patient scored on the basis of his responses to these six items. This test proved to be one way of distinguishing between hypochondriacal and non-hypochondriacal groups (P less than .005). However, because of the possibility of false positive results, the scale should be used only to confirm staff suspicions of hyponchondriasis and should not be used as part of the clinical intake procedure.

Aged↗
PubMed1978

Metastatic tumors of the endocardium: report of three cases.

Because of their apparent rarity and the tendency of clinicians to lump indicative signs and symptoms under the heading of metastatic disease, metastatic tumors of the endocardium are seldom mentioned in the literature, in the three cases presented herein, endocardial metastases were evident at autopsy. In one case of malignant melanoma, clinical evidence for endocardial involvement was present in life. This article also presents a case of endocardial involvement by Wilms' tumor and a case of endocardial involvement by hypernephroma with pulmonry tumor emboli.

Adenocarcinoma↗
PubMed1977

Improved quality of packed cells.

Improved viability, quality, oxygen delivery capacity and metabolic activity of packed cells was obtained when blood was collected into (CP2D) citrate-phosphate anticoagulant with extra dextrose and, after separation of plasma, stored in an adenine-enhanced electrolyte solution. The system has been incorporated into clinical transfusion practice.

Adenosine Triphosphate↗
PubMed1977

Meibomian gland carcinoma seeding intracranial soft tissues.

Meibomian gland carcinoma is a rare sebaceous gland malignant tumor of the eyelid. Local recurrence and regional lymph node metastases are common among this group of eyelid neoplasms. Distant liver metastases have been mentioned in one case report, but this represents and unusual finding. In addition to local recurrence and regional lymph node metastases, this autopsy case report demonstrates meibomian gland carcinoma with extension to the trigeminal ganglia and metastases to the cerebellum.

Adult↗
PubMed1977

Packed red cell transfusions -- improved survival, quality and storage.

Various anticoagulant-preservative solutions were investigated with a view to determining which would give optimal shelf life of packed cells. Satisfactory 24-hour post-transfusion survival (greater than 70%) after 28-day storage was obtained with citrate phosphate 277 mM dextrose, 0.25 mM adenine (CP2 X D-adenine). After addition of a rejuvenating electrolyte solution through a multiple closed plastic pack system, there was further improvement in viability, oxygen delivery capacity and metabolic activity of stored erythrocytes, with reduction in both plasma potassium and microaggregate numbers. No untoward reactions were observed during or after transfusion of 440 units of rejuvenated blood.

Blood Preservation↗