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Biomedical subjects

J Bryant

Publications and source records attributed to J Bryant.

At least 145 records · Page 8Linked to original sources
PubMed1987

A novel presentation of Coxsackie B2 virus infection during pregnancy.

A 39-year-old woman presented at 34 weeks gestation with a febrile illness. This initially settled but recurred 6 days later, when uncontrolled vaginal bleeding necessitated caesarian section. At operation, vesicles were seen on the mother's hyperaemic uterus. The infant developed tachypnoea, bradycardia, cerebral irritation, an enlarged liver and spleen, intravascular coagulation and a transient rash. Mother and child made a full recovery. Coxsackie B2 virus was isolated from the infant and rises in the titre of Coxsackie B virus-specific IgM were detected in mother and child.

Adult↗
PubMed1987

Pleomorphic lipoma of the bulbar conjunctiva.

We describe a patient who had most of the histologic features of the pleomorphic lipoma. Floret giant cells and nuclear pyknosis were well demonstrated in this case, and characteristic bubbly nuclear vacuolations were also seen. There was an absence of mitotic activity. The variable size of the adipocytes and nuclear pyknosis and the presence of collagen indicate an atrophying degenerative process in the formation of pleomorphic lipoma.

Conjunctival Neoplasms↗
PubMed1986

Efferent ductule cyst of tunica albuginea.

A cyst of the tunica albuginea is reported. For this cyst, anatomic arguments favor an efferent ductule origin over an origin from mesothelial rests. This cyst is an important benign differential diagnosis of a testicular mass and requires only local excision.

Adult↗
PubMed1986

Case reports.

Explore the source record for details and available documents.

Humans↗
PubMed1986

Concurrent cytomegalovirus and Coxsackie B virus infections in a heart-lung transplant recipient.

A 35-year-old woman with fibrosing alveolitis was given a combined heart and lung transplant at Papworth Hospital, Cambridge. Although her immediate post-operative course was satisfactory, she subsequently experienced concurrent primary cytomegalovirus and Coxsackie B virus infections associated with significant morbidity including pancreatitis. She made a full recovery and has remained well for more than 2 years after transplantation.

Adult↗
PubMed1985

Coxsackie-B-virus-specific IgM responses, complement-fixing islet-cell antibodies, HLA DR antigens, and C-peptide secretion in insulin-dependent diabetes mellitus.

To evaluate the role of Coxsackie B viruses in the pathogenesis of insulin-dependent (juvenile-onset, type 1) diabetes mellitus (IDDM), attempts were made to correlate virus-specific IgM responses with HLA genes, autoimmune responses, and C-peptide secretion. HLA DR3, DR4, or both were present in 73 of 90 (81%) diabetic patients; 22 of 23 (96%) with Coxsackie-B-virus-specific IgM had at least one of these HLA types, compared with 51 of 67 (76%) without virus-specific IgM. There was no correlation between HLA A, B, or C types or immunoglobulin allotypes and virus-specific IgM responses. 16 of 22 (64%) patients with Coxsackie-B-virus-specific IgM compared with 26 of 72 (36%) without had complement-fixing islet-cell antibodies; no relation was found between virus-specific IgM and antibodies against thyroid or adrenal tissue or parietal cells. C-peptide secretion was significantly lower in patients with Coxsackie-B-virus-specific IgM.

Adolescent↗
PubMed1985

Coxsackie B, mumps, rubella, and cytomegalovirus specific IgM responses in patients with juvenile-onset insulin-dependent diabetes mellitus in Britain, Austria, and Australia.

Patients from England, Austria, and Australia with recently diagnosed juvenile-onset insulin-dependent diabetes (type 1) mellitus (IDDM) and matched controls were tested for specific IgM responses to Coxsackie B1-5 viruses. 37 of 122 (30%) patients aged less than 15, but only 15 of 204 (6%) controls, were positive (p less than 0.005). Differences in Coxsackie B virus specific IgM responses between patients and controls were statistically significant for patients in England and Austria (p less than 0.005). Coxsackie B virus specific IgM responses were detected in only 3 of 31 patients aged greater than 16. Virus-specific IgM responses were directed against a single serotype, usually Coxsackie B4 or 5, in 23 of 37 (62.5%) children aged less than 15; 10 of 13 (77%) of children aged less than 7 had monotypic responses. Among families of Austrian patients with IDDM, 8 of 79 (10%) siblings had Coxsackie B virus specific IgM responses, 1 of whom subsequently had IDDM, but none of the 80 parents was positive. In contrast, there was no evidence of recent infection by mumps, rubella, or cytomegalovirus (CMV), since mumps-virus specific IgM was present in only 2 of 100 children with IDDM and 5 of 139 controls; no rubella or CMV specific IgM responses were detected in 60 sera from patients with IDDM.

Adolescent↗
PubMed1985

Basal cell carcinoma associated with keratoacanthoma.

This report describes a basal cell carcinoma associated with a keratoacanthoma, showing a histologic transition between the two lesions. Two previously reported cases of basal cell carcinoma are associated with keratoacanthoma, but do not show a transition between the two lesions. The malignant potential of the keratoacanthoma in this case is emphasized.

Basal Cell Carcinoma↗
PubMed1983

Impact of a maternal transport program on a newborn service.

We reviewed the maternal transfers for one year (1980) to the Emory Perinatal Center, a tertiary care center for North Georgia. Of 445 telephone consultations or patient referrals, 150 women gave birth at the tertiary center. Indications for maternal transfer were predominantly based on the needs or anticipated needs of the fetus. There were a total of 163 births, 10 of them stillborn and 153 live-born. Three infants expired in the delivery room. Sixty infants (40%) required 580 days of intensive care. A total of 1,439 days of care in the intermediate unit was required and 1,077 days of care in other areas of the nursery. Adjusting these figures for a 0.8 occupancy rate revealed that two intensive care beds, 4.9 intermediate care beds, and 3.6 minimal care beds were required for just these maternally transported infants. Maternal transfers will result in a disproportionate increase in the workload of a nursery because of the immaturity and small size of these infants. When considering a maternal transfer service, appropriate planning must be made to meet the special needs of both the infants and their mothers.

Birth Weight↗
PubMed1982

Enhanced cell killing through the use of cell kinetics-directed treatment schedules for two-drug combinations in vitro.

Kinetics-directed drug treatment schedules were tested in Chinese hamster ovary cells. Ten hr after treatment with 1,2:5,6-dianhydrogalactitol (DAG) (at a dose lethal to less than 5% of the cells), a 150% enrichment of cells into the S phase of the cell cycle was observed. This blockade in S phase was reversible and was followed at 18 hr after an exposure to DAG by a 200% increase in the fraction of cells in the G2-M phases of the cell cycle. Bleomycin, known to be most effective against G2 + M cells, had the greatest effect on cell killing when administered at that time. Rapid analysis by flow microfluorometry techniques was used to determine the DAG-induced kinetics changes, thus allowing treatment with the second drugs at the most opportune time. The DAG-induced kinetics changes were also demonstrated in a line of human adenocarcinoma of the stomach in vitro and in Ehrlich ascites tumor cells in vivo. In all cases, the enrichment of cells into S phase was reversible at the doses used and was followed by a reversible blockade in G2-M.

Adenocarcinoma↗