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Biomedical subjects

J Brun

Publications and source records attributed to J Brun.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

[Daily profiles of melatonin, cortisol and gonadotropins in 8 adolescents with anorexia nervosa].

From a biological study of 8 patients with anorexia nervosa and an analysis of the daily profiles of gonadotropins, cortisol and melatonin, the authors discuss the possible relationship between anorexia nervosa and affective disorders. At the initial phase of the illness, plasmatic levels of FSH, LH and oestradiol were very low. 24-hour plasma cortisol values were comparable with those of a depressive population; when weight loss was equal to or higher than 25% of the initial weight, there was no suppression by dexamethasone. The daily profile of melatonin was maintained, with melatonin plasma levels significatively higher than in a control group of depressed patients.

Adolescent↗
PubMedDate not supplied

[Effect of acute administration of antidepressive agents at 2 P.M. on plasma and pineal levels of melatonin in the rat].

The authors measured the effect of different antidepressant drugs on the pineal production of melatonin in order to see if this test can be used in an antidepressants screening protocol. Six antidepressant drugs belonging to different pharmacologic classes have been tested. The results show that all the molecules used enhance the plasmatic and pineal concentration of melatonin. However the selectivity of this test must be reinforced by using classical methods for the detection of an antidepressant effect.

Animals↗
PubMedDate not supplied

[Melatonin. Chronobiologic peripheral endocrine index in depressive states].

The chronobiological studies with melatonin constitute valid arguments to consider melatonin as a peripheral index of depressive disorders. In a group of patients with major depression, we reported a lowering of melatonin nocturnal plasma levels, associated with cortisol hypersecretion. A similar lowering of melatonin was observed in a group of patients with cluster headaches, but without quantitative modification of cortisol secretion. Other studies are necessary in order to determine wether melatonin may be considered as a "state marker" of depression itself or a marker of the genetic vulnerability to depression.

Adult↗