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Biomedical subjects

J Braun

Publications and source records attributed to J Braun.

At least 595 records · Page 33Linked to original sources
PubMed1976

Melioidosis complicated by pericarditis.

A case of acute and recrudescent melioidosis complicated by pericarditis and pericardial effusion is described. The potential for the appearance of future cases in the United States and the necessity for physicians to remain aware of this potential diagnosis are discussed.

Adult↗
PubMed1976

Abnormalities of urinary sediment and renal failure following sulfinpyrazone therapy.

A patient with recurrent thrompophlebitis had sterile pyuria with white blood cell casts and transient, mild renal failure during therapy with sulfinpyrazone. These abnormalities resolved on cessation of therapy, but similar changes in the urinary sediment recurred during therapy with sulfinpyrazone. These abnormalities resolved on cessation of therapy, but similar changes in the urinary sediment recurred during a second course of sulfinpyrazone therapy.

Acute Kidney Injury↗
PubMed1975

Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation.

The sensitivity of cells exposed in vitro to the antibiotics bleomycin or adriamycin is only mildly increased at 41 degrees over that seen at 37 degrees. However, at 43 degrees a marked synergism between the effects of hyperthermia and drug is observed. This synergism can also be demonstrated to occur in solid tumors in vivo. Cells after bleomycin exposure at 37 degrees repair potentially lethal damage, and 43 degrees inhibits this repair. This inhibition may in part account also for the observed sensitization of the cells to bleomycin, but not to adriamycin, since for the latter no repair can be demonstrated. However, fluorescence measurements show that at 43 degrees much more adriamycin is able to enter the cells than at 37 degrees. The possible implications of the results for cancer treatment are discussed.

Animals↗
PubMed1975

Enhanced cell killing by bleomycin and 43 degrees hyperthermia and the inhibition of recovery from potentially lethal damage.

The effect of hyperthermia on bleomycin (BLEO) toxicity and repair was studied in "unfed" monolayer cultures of Chinese hamster cells. Synergy of toxicities was observed with simultaneous exposure to BLEO and 43 degrees. For example, when cells were exposed for 1 hr to BLEO (40 mug/ml) at 43 degrees, survival was reduced to 4 X 10(-5); separately, hyperthermia and 37 degrees BLEO exposure each resulted in a survival of 20%. Heating at 43 degrees prior to drug exposure at 37 degrees also produced substantial sensitization, indicating that the primary sensitizing effect involved cell damage rather than an increased rate of drug action; 41 degrees produced only modest cell sensitization to BLEO and the effect was not retained in cells heated prior to drug exposure. No increase in [14C]BLEO uptake was observed at 43 degrees over than at 37 degrees, and thus the increased cytotoxicity was not correlated with a gross change in cell permeability to BLEO, although increased drug availability to particular sensitive targets could not be ruled out. Studies of the repair kinetics after different 43 degrees BLEO protocols demonstrated that most of the cells sustaining potentially lethal damage rapidly recovered. However, 43 degrees hyperthermia inhibited this recovery and, with increasing durations of 43 degrees exposure, the fixation of potentially lethal damage was enhanced. Because of the substantial repair of BLEO damage observed in vivo, the possible usefulness of hyperthermia as an adjunct to BLEO therapy is discussed.

Animals↗