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Biomedical subjects

J Borbujo

Publications and source records attributed to J Borbujo.

34 records · Page 2Linked to original sources
PubMed1993

Anticardiolipin antibodies in autoimmune thyroid disease.

IgG and IgM anticardiolipin antibodies were assayed by an ELISA technique in 69 patients with autoimmune thyroid disease (ATD) and compared with 43 patients with thyroid disease of no autoimmune aetiology (non-ATD) and 72 healthy controls. IgG anticardiolipin antibodies were detectable in 3 of 41 patients with Graves' disease, in 4 of 28 patients with Hashimoto's thyroiditis, in 5 of 43 non-ATD patients and in 3 of 72 normal subjects (differences not significant). IgM antibodies were measurable in 3 patients with Graves' disease, in 1 patient with Hashimoto's thyroiditis, in 1 non-ATD patient and in 2 normal subjects (differences not significant). Patients with anticardiolipin antibodies did not exhibit a higher titre of thyroglobulin or thyroid microsomal antibodies than patients without anticardiolipin antibodies. There was no relation between IgG or IgM anticardiolipin antibody levels and the thyroid function status, the serum concentration of thyroid hormones or thyrotrophin levels. Neither was there any correlation between anticardiolipin antibody levels and age, sex, previous treatments or time of disease progress. Our results suggest that there is no association between anticardiolipin antibodies and ATD.

Adolescent↗
PubMed1992

Multiple linear cylindromas.

We report a case of multiple cylindromas with a linear arrangement on the lower right extremity. The patient had more than 100 tumors, but the scalp was spared. Some tumors showed overlapping features with eccrine spiradenoma. We believe this is the first report of multiple linear cylindromas.

Adenoma, Sweat Gland↗
PubMed1991

Alpha 1- and alpha 2-adrenergic response in human isolated skin arteries during cooling.

1. Dose-response curves for noradrenaline, phenylephrine and clonidine were determined isometrically in 2-mm cylindrical segments from human skin arteries at 24 degrees C and compared to those previously reported at 37 degrees C. 2. Noradrenaline (3 x 10(-10)-3 x 10(-4) M) induced dose-dependent contraction and the sensitivity was increased during cooling. Phentolamine (10(-6) M), prazosin (10(-6) M) or yohimbine (10(-6) M) produced a higher rightward shift of the control curve for noradrenaline during cooling. 3. Phenylephrine (10(-11)-3 x 10(-4) M) and clonidine (10(-11)-10(-6) M) caused dose-dependent contraction and the sensitivity of the arteries was augmented at 24 degrees C. 4. The arteries also showed a lower maximal contraction to the adrenergic agonists used and KCl (50 mM) during cooling. 5. The results suggest that cooling: (a) increases sensitivity of postjunctional alpha 1- and alpha 2-adrenoceptors in human skin arteries and (b) depresses contractility of these arteries to alpha-adrenergic stimulation and direct activation of vascular smooth muscle.

Adult↗
PubMed1989

Keratoderma palmoplantaris striata.

A patient with keratoderma palmoplantaris striata is presented. In the family tree there are 36 relatives affected to a varying degree. The familial incidence is the largest reported in the literature reviewed. The response to etretinate was excellent, controlling the lesions with minimal side-effects.

Adult↗
PubMed1989

Plasma neuropeptide pattern in acute idiopathic urticaria.

Immediate hypersensitivity responses, as acute urticaria, produce a release of neuropeptides by nerve endings, which present specificity of recognition by mast cells, basophils and other target cells. We have measured vasoactive intestinal peptide (VIP), somatostatin, bombesin, neurotensin and beta-endorphin by radioimmunoassay in plasma extracts of 20 patients with acute idiopathic urticaria and of 20 healthy subjects. VIP- and beta-endorphin-like immunoreactivities were found to be significantly decreased with respect to controls (p less than 0.001 and p less than 0.01, respectively). On the contrary, somatostatin- and bombesin-like immunoreactivities were significantly increased (p less than 0.001 and p less than 0.05, respectively). These findings could be a reflection in blood of a raised release of somatostatin and bombesin by nerve endings in the urticaria process. Moreover, the decreased plasma levels of VIP- and beta-endorphin-like immunoreactivities could be explained by a raised specific metabolism of these peptides in the urticaria process.

Adult↗
PubMed1989

Postjunctional alpha-1 and alpha-2 adrenoceptors in human skin arteries. An in vitro study.

Experiments were performed to characterize the postjunctional alpha adrenoceptors that mediate adrenergic constriction in human skin arteries. Abdominal s.c. arteries were obtained from patients who died 3 to 12 hr before, and vascular segments 2 mm in length and 600 to 1050 microns in external diameter were prepared for isometric tension recording. On application of norepinephrine, phenylephrine (alpha-1 adrenergic agonist) or clonidine (alpha-2 adrenergic agonist) the arteries contracted in a dose-dependent manner and, in terms of the mean EC50 values, the order of potencies was clonidine greater than norepinephrine greater than phenylephrine. With regard to their ability to induce maximal contraction, the order was norepinephrine = phenylephrine greater than clonidine. In the presence of phentolamine (nonspecific alpha adrenergic antagonist) or yohimbine (selective alpha-2 adrenergic antagonist) the control curve for norepinephrine was displaced to the right in a parallel way. Prazosin (selective alpha-1 adrenergic antagonist) depressed both the slope and maximal response of the control curve for norepinephrine but the shift was not significant. Prazosin and yohimbine produced a parallel rightward shift in the control curve for phenylephrine and clonidine, respectively. These results suggest that skin arteries of humans have a mixed population of postjunctional alpha-1 and alpha-2 adrenoceptors and that alpha-2 adrenoceptors are more prominent. They also suggest that the alpha-2 adrenergic component of the response to norepinephrine is a low-maximum effect compared to the alpha-1 adrenergic component. This could be of significance in regulating skin blood flow and thermoregulatory function.

Adult↗
PubMed1988

Spontaneous healing of Kaposi's angiosarcoma of the penis.

We report a case of Kaposi's angiosarcoma of the penis. Few cases have been reported of the initial and exclusive involvement of Kaposi's angiosarcoma of the glans penis and prepuce. Our case is unique because of the number of lesions and the spontaneous remission.

Aged↗
PubMedDate not supplied

A newborn with nodular ulcerated lesion on a giant congenital nevus.

The proliferative nodule is a lesion that develops within a congenital nevus. It is usually small (less than 5 mm), sometimes multiple, with a slow growth rate, and has a black or dark brown, smooth, shiny surface. It usually involutes spontaneously. We report a newborn infant who, at birth, had a giant congenital nevus with a nodular, ulcerative, hemorrhagic lesion within it. Physical and neurologic examinations were normal. Radiologic studies at birth and subsequently were normal. A fragment of the lesion was biopsied and histologic findings were compatible with a diagnosis of proliferative nodule in a giant congenital nevus. The rest of the nodule regressed spontaneously after 4 months.

Diagnosis, Differential↗
PubMedDate not supplied

[Amyloidosis maculosa: diagnosis in primary care].

Amyloidosis maculosa is a clinical entity with low incidence factor in our medium, which basically affects middle-aged women. The lesion is characterised by the presence of poorly defined, hyperpigmented, brownish or greyish maculae that converge and focus basically on the upper back and shoulders, usually accompanied by pruritus. Three patients were erroneously catalogued for years as having pityriasis versicolor. Two of these patients presented a typical clinical amyloidosis maculosa, and the third presented a less common manifestation of the disease: a single, well-defined lesion in the subscapular region. We believe that the approach to the diagnosis of pityriasis versicolor with hyperpigmented lesions that do not respond to specific treatment should be revised. Although amyloidosis maculosa has a low incidence in our medium, it is an entity which should not be discarded in these cases.

Adult↗