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Biomedical subjects

J Borbujo

Publications and source records attributed to J Borbujo.

At least 19 recordsLinked to original sources
PubMed1996

Subungual hemorrhages. A primary manifestation of diabetes mellitus.

Subungual hemorrhages may be observed in a variety of systemic diseases and in some otherwise healthy persons. We describe three male patients who were referred because of toenail hemorrhages. Analytical investigations showed hyperglycemia in all the patients. Toenail bilateral hemorrhages were the first manifestation of previously undiagnosed type II diabetes mellitus in all cases. Ophthalmologic examination showed signs of background diabetic retinopathy in all three patients. The existence of retinopathy suggests that subungual hemorrhages might be due to microvascular involvement and could herald the presence of diabetes mellitus.

Aged↗
PubMed1996

Dermatomyositis and flagellate erythema.

Flagellate erythema, described by Moulin in 1970 as reminiscent of the lesions produced by flogging and by other authors as zebra-like lesions, was noted first in association with bleomycin treatment, but later occasionally reported in relationship with dermatomyositis, mostly from Japan. It is characterized by linear, erythematous, cutaneous streaks, pruriginous or painful, arising on an oedematous background and disappearing spontaneously over several weeks. So far, fewer than five cases have been reported in association with dermatomyositis, but we now present a further one.

Back↗
PubMed1996

[Cutaneous infection caused by Mycobacterium chelonae. Presentation of 3 cases with multiple lesions].

OBJECTIVE: To review the clinical, diagnostic, therapeutic and prognostic characteristics of cutaneous diseases caused by atypical mycobacteria and more specifically those by Mycobacterium chelonae. To improve our knowledge of this disease and its differential diagnosis with other cutaneous infections associated with folliculitis. DESIGN: Retrospective descriptive study. SETTING: Primary care and Dermatology specialty in a Health Center in the Madrid metropolitan area. PATIENTS AND OTHER PARTICIPANTS: The clinical records of non immunosuppressed patients, with multiple cutaneous lesions caused by Mycobacterium chelonae and confirmed by culture were reviewed. The evolution time, treatment regimes before diagnosis and possible epidemiological factors were studied. MEASUREMENTS AND MAIN OUTCOMES: Culture confirmed three non immunosuppressed patients with multiple lesions in both legs. Lesions had been present for longer than two months and had been treated with topical and systemic antibiotics with no improvement. The only relevant epidemiological finding was wax depilation. CONCLUSIONS: It is important to know the existence of this type of infection, since diagnostic suspicion allows for an early and efficient therapy which will present the emergency of important scars.

Adolescent↗
PubMed1994

Rubinstein-Taybi syndrome with piebaldism.

A young girl is reported suffering from multiple congenital anomalies typical of Rubinstein-Taybi syndrome, in association with cutaneous lesions of piebaldism and occipital poliosis. Clinical characteristics of both entities are described and cutaneous manifestations of Rubinstein-Taybi syndrome are reviewed. To the best of our knowledge, this is the first case reporting such an association.

Child↗
PubMed1994

Cooling effects on the histaminergic response of rabbit ear and femoral arteries: role of the endothelium.

The effects of cooling on the isometric response of rabbit isolated central ear (cutaneous) and femoral (non-cutaneous) arteries to histamine were determined at 37 degrees C and 24 degrees C (cooling). Under resting tension, both types of arteries contracted to histamine (10(-7)-10(-3) M), and the sensitivity of ear arteries, but not of femoral arteries was lower at 24 than at 37 degrees C. Chlorpheniramine (10(-7) M) blocked the contraction of both types of arteries to histamine at both temperatures. In ear arteries, endothelium removal or treatment with the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 10(-5) M) did not affect the contraction to histamine at 37 degrees C, but it reversed the decreased contraction at 24 degrees C. In femoral arteries, endothelium removal or L-NAME (10(-5) M) did not affect the response to histamine at 37 and 24 degrees C. Ear and femoral arteries precontracted with endothelin-1 (10(-8)-10(-7) M) and pretreated with chlorpheniramine (10(-5) M) relaxed to histamine (10(-7)-10(-4) M), and the sensitivity of this relaxation in ear arteries, but not in femoral arteries, increased at 24 degrees C. The relaxation of ear and femoral arteries to histamine was not modified by endothelium removal, L-NAME (10(-5) M) or meclofenamate (10(-5) M), but it was blocked by cimetidine (10(-6) M) at 37 degrees C and 24 degrees C. These results suggest: (1) ear and femoral arteries have contracting H1 and relaxing H2 receptors, probably located on smooth musculature, and (2) cooling reduces the contraction and increases the relaxation of cutaneous arteries to histamine: the reduction of this contraction could be caused by an augmented availability of endothelial nitric oxide, and the increment of this relaxation could be caused by an augmented sensitivity of H2 receptors of smooth musculature induced by cooling. These features do not seem to occur in deep vessels.

Animals↗
PubMed1993

[Molluscum contagiosum: one year examination at a health center].

OBJECTIVE: To study the prevalence of Molluscum contagiosum in our environment, in order to understand and control it better. DESIGN: A retrospective descriptive study was undertaken. SETTING: The Dermatology Clinic of the "V Centenario" Health Centre at San Sebastián de los Reyes (Madrid). PATIENTS: All cases diagnosed during 1991 were selected. MEASUREMENTS AND MAIN RESULTS: The following variables were analysed: age, sex, date of the consultation, duration of the lesions, family members affected, number and site of the lesions, referral diagnosis and HIV serology. The method of comparing proportions was used for the analysis. Twenty-nine patients (9 female), with an average age of 12 +/- 11 years, were diagnosed: this supposed 0.37% of the patients seen at the clinic over a year. Six patients identified a possible source of contagion. 55.2% had less than 5 lesions. The most common site was the trunk (44.8%) and extremities (48.2%). Only 24% had a correct diagnosis in the interclinic notes. 20.7% were not diagnosed. Two patients were HIV (+); both with numerous lesions in the genital area. All the cases were treated by mechanical means. CONCLUSIONS: Knowledge of the disease must be improved, to make diagnosis more rapid and thus avoid transmission; given that diagnosis and treatment is simple and completely attainable at the Primary Care level.

Adolescent↗
PubMed1993

Anticardiolipin antibodies in autoimmune thyroid disease.

IgG and IgM anticardiolipin antibodies were assayed by an ELISA technique in 69 patients with autoimmune thyroid disease (ATD) and compared with 43 patients with thyroid disease of no autoimmune aetiology (non-ATD) and 72 healthy controls. IgG anticardiolipin antibodies were detectable in 3 of 41 patients with Graves' disease, in 4 of 28 patients with Hashimoto's thyroiditis, in 5 of 43 non-ATD patients and in 3 of 72 normal subjects (differences not significant). IgM antibodies were measurable in 3 patients with Graves' disease, in 1 patient with Hashimoto's thyroiditis, in 1 non-ATD patient and in 2 normal subjects (differences not significant). Patients with anticardiolipin antibodies did not exhibit a higher titre of thyroglobulin or thyroid microsomal antibodies than patients without anticardiolipin antibodies. There was no relation between IgG or IgM anticardiolipin antibody levels and the thyroid function status, the serum concentration of thyroid hormones or thyrotrophin levels. Neither was there any correlation between anticardiolipin antibody levels and age, sex, previous treatments or time of disease progress. Our results suggest that there is no association between anticardiolipin antibodies and ATD.

Adolescent↗
PubMed1992

Multiple linear cylindromas.

We report a case of multiple cylindromas with a linear arrangement on the lower right extremity. The patient had more than 100 tumors, but the scalp was spared. Some tumors showed overlapping features with eccrine spiradenoma. We believe this is the first report of multiple linear cylindromas.

Adenoma, Sweat Gland↗