Biomedical subjects
Publications and source records attributed to J Biermann.
From the bark extract of Discaria febrifuga Mart. the known alkaloids frangufoline (I), adouétine (II), scutianine B (III), franganine (IV) and two new ones, discarine C (V) and D (VI), were isolated. Their structures are elucidated by degradation reactions and spectroscopic investigations.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The physical working capacity 170 (PWC 170) exhibits a characteristic age-dependent course: With advancing age the values increase, although the physical performance capacity decreases. This reaction points to a slow responding heart rate in elderly individuals. After a four weeks treatment in a rehabilitation center combined with a high level of physical activity there was a decline of the PWC 170 in middle-aged persons. These results show that regular exercise generates a pronounced acceleration of the heart rate; this adaptive functional situation leads to a fast adjustment of the heart rate to the actual level of the load. In untrained elderly individuals the PWC 170 is no reliable parameter to indicate the physical performance capacity and the cardiac adaptation.
203 patients with an average age of 52.1 having been sent to undergo a 4-week course of cardiovascular treatment, took daily physical exercise at low intensity, the effects of which on parameters of the cardiovascular system and on the metabolism are shown. VO2 max in men was increased by 15.1%. Heart rate and blood pressure fell significantly. The reduction of the absolute values of serum lipids (cholesterol and triglycerides) and the arteriosclerosis indices LDL-C/HDL-C and Apo B/Apo A1 confirm that it is possible to reduce the cardiovascular hazard by physical exercises in elderly people, too.
The effect of a daily swimming-training of 20--30 minutes for four weeks (six times a week with intensities of 50--60% VO2 max) on the lipid and lipoprotein spectrum, respectively, was investigated in 40 elderly male patients in a heart-circulatory cure (on an average 48,7 years old). At the beginning all patients had an HDL-cholesterol level lower than 0.91 mmol/l which rose significantly towards the end of the cure. LDL-cholesterol dropped significantly. The lipid index by Klimov and the quotient LDL-C/HDL-C descended at the end cure. The separation of the lipoproteine (Lp) by discelectrophoresis and the evaluation of their percentage showed a reduction of the beta-Lp and an increase of the alpha-Lp coinciding with the lipid-data. The quotient beta-Lp/alpha-Lp also decreased significantly. In the apolipoproteins A and B statistically ensured alterations in concentrations could not be determined. The disproportional changes of the lipid- and protein-portions were referred to in the discussion. According to our results the lipid-portion of the Lp (especially LDL- and HDL-cholesterol) indicated the changes more sensitively than the apolipoproteins A and B. The data demonstrate the possibility of raising the HDL-cholesterol-level of elderly men by physical training.