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Biomedical subjects

J Beyer

Publications and source records attributed to J Beyer.

At least 433 records · Page 24Linked to original sources
PubMed1981

C-peptide-measurement: a simple method for the improvement of specificity.

Sera containing insulin antibodies and proinsulin give artifactual high readings in C-Peptide measurement. This problem can be circumvented by the removal of antibodies and proinsulin prior to C-Peptide assay. A method is described which enables the removal of antibodies and proinsulin from sera without affecting the C-Peptide determination. Furthermore, this method allows a semiquantitative estimation of proinsulin, provided there is enough cross reactivity of the C-Peptide antibody with proinsulin.

Animals↗
PubMed1981

Effects of permeation of plasma proteins in diabetic patients.

A within-person trial in 35 diabetic subjects investigated the effect of six months' administration of 750 mg of calcium dobesilate daily on the erythrocyte sedimentation rate, erythrocyte and leucocyte counts, platelet aggregation, blood cholesterol and triglyceride concentrations, total serum protein concentration, electrophoretically determined serum proteins fractions, and the escape rate of intravenously injected 131-I-albumin. Significant increases in intravenous retention of 131-I-albumin, serum albumin and beta-globulin fractions, and total serum protein concentration resulted. No change in the remaining variables was detected. The results suggest that calcium dobesilate reduces pathologically increased transcapillary escape rate in diabetes mellitus.

Benzenesulfonates↗
PubMed1980

[Effect of calcium dobesilate on permeation of plasma proteins in diabetic patients].

The effect of six months of treatment with 750 mg calcium dobesilate on sedimentation rate blood count, cholesterol, triglycerides, platelet aggregation factor, total protein, electrophoretic distribution of serum protein concentrations, and kinetics of intravenous albumin marked with 131I was established in 35 diabetics with a mean duration of diabetes of 9.8 years. There was significant intravascular retention of 131I albumin and significant increase of serum albumin, beta-globulins and total protein after treatment. The other parameters remained unchanged. The results are interpreted as evidence of lowering of the increased transcapillary permeability within the vascular system seen in diabetics.

Aged↗
PubMed1980

[Glucose assimilation, insulin secretion and insulin sensititivy in psoriasis patients].

The discussion about a connection between diabetes and psoriasis is picked up again. Serum-values of glucose, insulin and C-peptide after intravenous glucose-load and of glucose and C-peptide after intravenous insulin-load were tested. The level of insulin and C-peptide after i. v. glucose-load was found higher in psoriasis-patients (hyperinsulinism). Considering earlier investigations and new results in diabetes-research (incretin concept), a connection between the two diseases must be denied. The carbohydratemetabolism-deviation in psoriasis could be declared by an enteropathy.

C-Peptide↗
PubMed1980

The effect of PEEP ventilation on hemodynamics and regional blood flow with special regard to coronary blood flow.

An experimental study was performed to evaluate the effects of positive end-expiratory pressure (PEEP) on central hemodynamics and on regional blood flow (RBF) using the radioactive microsphere (MS) method. Ten dogs with intact lungs and 10 dogs with oleic acid-induced pulmonary edema were ventilated with PEEP 10 and PEEP 20 (cmH2O). PEEP significantly reduced cardiac output (CO) by 25% at PEEP 10 and 40--50% at PEEP 20 despite volume expansion with dextran 60. RV afterload rose markedly due to a significant increase of pulmonary vascular resistance. PEEP tended to redistribute CO in favor of brain, heart and adrenals, at the expense of stomach, pancreas and thyroid glands. Hepatic artery flow was moderately reduced; renal RBF was seriously affected only when PEEP caused an extreme low-output state. RBF to the RV remained essentially unchanged, whereas RBF to the LV decreased, roughly paralleling the respective ventricular work. Nevertheless, the RV may suffer from underperfusion during PEEP, since its tension-time-index rises; this may indicate increased oxygen needs exceeding actual oxygen delivery.

Adrenal Glands↗
PubMed1980

Glucagon secretion in four duodenopancreatectomized patients after arginine and glucose load.

It is well established that in sera of totally duodenopancreatectomized dogs after complete insulin deprivation an immunoreactive glucagon can be found, which is indistinguishable from the pancreatic glucagon, and which can be stimulated by oral glucose and i.v. arginine as well. In four duodenopancreatectomized patients we found, after 26 h insulin deprivation, normal and elevated basal levels of IRG which were not stimulated by intravenous arginine but by oral glucose. Dilution tests of the sera before glucose stimulation showed immunological properties different from pancreatic standard glucagon, whereas in sera after stimulation immunoidentity with pancreatic standard glucagon could be demonstrated. Gel chromatography of the sera after stimulation yielded at least three immunoreactive peaks, the first over 30 000 daltons, a second eluting in the region of insulin, and a third of about 2000 daltons. True glucagon (3500 MW) could not be clearly demonstrated.

Adult↗
PubMed1980

Treatment of delayed puberty by intranasal application of gonadotropin-releasing hormone (GnRH).

Seven male patients between 15(5)/12 and 19(6)/12 years of age with delayed puberty, two of them anosmic, received 200 microgram GnRH nasally (N) six to eight times daily for a period of 3 months, or in one case for 6 months. Changes in basal secretion and responsiveness of the gonadotropins were recorded by serial GnRH tests. Serial measurements of serum testosterone (T) were also done. While serum T, before treatment, was low it prepubertal levels in all patients, basal serum gonadotropins and gonadotropin responsiveness in the GnRH tests were found to be within the adult range in most of the patients. In the two anosmic patients, after 2 to 4 weeks of treatment decreasing gonadotropin responsiveness of GnRH was observed, and no, or only transitory, increases of serum T were found. In another patient, in spite of sustained gonadotropin responsiveness of GnRH throughout the treatment, no increase of serum T was seen which is probably due to additional primary Leydig cell deficiency. In the other four patients increases of serum T were observed which, however, did not reach the middle of the normal adult range. If stimulation of T secretion was achieved a further increase of serum T was observed after termination of the treatment. Thereafter, serum T returned to pretreatment values in one patient or stayed within the normal adult range in two other patients. No significant effects on clinical parameters were found with the GnRH therapy. This is probably due to the short duration of therapy in these patients as well as to the changes in serum T observed during the treatment, which are small in comparison to gonadotropin therapy.

Administration, Intranasal↗
PubMed1980

Plasma catecholamines in long-term diabetes.

To investigate a possible defect in sympathetic innervation of the blood vessels in diabetics, 18 normals, 13 normotensive juvenile diabetics without complications and 13 normotensive juvenile diabetics with complications were first treated with an increasing infusion of norepinephrine (NE) and subsequently given a two minutes' exercise with a 150 Watt load. Plasma catecholamines were measured under both conditions. In the infusion experiments diabetics were found to have higher NE levels than normals. In normals NE fells to starting levels 5 min. after completion of the work load. In diabetics this fall-back rate was slower. The reduction in the fall-back rate was correlated with the duration of the diabetes.

Adult↗
PubMed1980

[Regional blood flow in splanchnic organs during positive end-expiratory pressure ventilation (author's transl)].

An experimental study was performed on 10 dogs to evaluate the effect of positive end-expiratory pressure ventilation (PEEP) on hemodynamics and regional blood flow (RBF). The following conclusions can be drawn from the results of this study: 1) PEEP leads to a significant reduction of cardiac output (CO). 2) Total blood flow to the preportal splanchnic organs, and consequently the portal venous flow, decreases in proportion to the reduction of CO. Within the splanchnic area, there is a redistribution of RBF in favour of the small and large intestines, at the expense of stomach and pancreas. 3) The arterial blood flow to the liver is only moderately affected. 4) The observed changes of RBF may in part contribute to the complications of the splanchnic organs occurring in PEEP-ventilated patients. 5) PEEP should be used only when strictly indicated; close monitoring of organ function appears mandatory in these patients.

Animals↗
PubMed1980

[Studies on the reliability of hard diagnosis of Marek's disease and lymphoid leukosis of chickens on the basis of pathologic-anatomical findings].

The reliability of criteria for diagnosis and differential diagnosis of Marek's disease and lymphoid leucosis of fowl, as part of herd diagnosis and on the basis of pathologico-anatomic findings as well as of pathomorphological and statistical tests has been checked for treatment in this paper. Tumorous lesions were macroscopically and histologically recorded from 1,261 hens of various industrialised poultry units. Marek's disease was established in 316 cases, lymphoid leucosis in 828 cases, mixed manifestations in 33 cases, and other neoplasias in 84 cases. These animals, together with 591 hens in which Marek's disease had been experimentally induced, were evaluated by pathologico-anatomic criteria of differential diagnosis. The conclusion was drawn that differential diagnosis of Marek's disease and lymphoid leucosis on the basis of pathologico-anatomic findings, without histological testing, was sufficiently reliable, when undertaken as part of herd diagnosis monitoring. The expected small number of false diagnoses will be unimportant to herd diagnosis. Both diagnosis and differential diagnosis will be conducted by the following criteria: age of animal, alterations caused by Marek's disease to nerves, eyes, and skin, tumour growth in bursa fabricii caused by lymphoid leucosis, atrophy of bursa fabricii caused by Marek's disease, as well as differences between both diseases regarding tumour development in other organs, with due consideration to be given to the number of affected organs, as a whole, and to pathologico-anatomic organic changes caused by tumour growth.

Animals↗
PubMed1979

[Modern methods in localization of pheochromocytomas (author's transl)].

In six patients with adrenal pheochromocytoma the tumors were localized by ultrasonography, phlebography of the adrenal glands and by estimation of plasma catecholamines selectively obtained from the vena cava and the adrenal gland veins. All tumors were localized by selective catecholamine estimation, five by ultrasonography, and four by phlebography. The smallest pheochromocytoma of 1.5 g weight was only localized by selective catecholamine estimation but not by ultrasonography or phlebography. This tumor, however, had been visualized by computed tomography. To avoid diagnostic errors by selective catecholamine estimation, it is important to withdraw blood from the adrenal gland veins prior to the injection of any radiographic contrast media, since this may result in an extremely enhanced secretion of catecholamines from the adrenal medulla.

Adrenal Gland Neoplasms↗
PubMed1979

[The diagnosis of phaeochromocytoma: sensitivity of vanillylmandelic acid and urinary catecholamine determination and the Katecult test (author's transl)].

Tumour weight was compared with maximal vanillylmandelic acid and catecholamine excretion in 24-hour urine in 21 patients with phaeochromocytoma. The tumour weight correlated both with vanillylmandelic acid (r = 0.805, P less than 0.001) as well as urinary catecholamine levels (r = 0.725, P less than 0.001). Normal vanillylmandelic acid excretion was found in seven patients; urinary catecholamine levels were abnormal in all patients. The Katecult test was additionally performed in ten patients, with nine positive results.

Adrenal Gland Neoplasms↗
PubMed1979

[Endocrinological prediction of the responsiveness of depressive patients to lofepramine (author's transl)].

In a pilot study of 15 depressive patients of the neurotic and endogenous type we could show that some neuroendocrinological parameters are apt to predict the thymoleptic efficacy of lofepramine. These parameters, which were measured with a simple global stimulation test (insulin hypoglycaemia combined with injection of TRH and LHRH), were as follows: high basal blood glucose; high hypoglycaemic blood glucose; high decrease of blood glucose in comparison to the basal level; low basal TSH; low increase of HGH and low increase of cortisol after hypoglycemia. A synopsis of these parameters allowed a correct classification of 14 out of 15 patients according to therapy response and therapy resistance.

Adult↗
PubMed1979

[Adrenal and extra-adrenal phaeochromocytoma: diagnostic features and localisation by determining plasma catecholamines (author's transl)].

Urinary catecholamines and urinary excretion of vanillylmandelic acid confirmed the diagnosis of phaeochromocytoma in ten patients. In two of seven a modified glucagon test significantly aided confirmation of the diagnosis. In all patients the tumour was localised both by catecholamine determination in blood from the vein draining into the inferior vena cava (IVC) and by adrenal phlebography. Site of the adrenal tumour was definitively determined by the high catecholamine level in the adrenal veins and by phlebography. Three extra-adrenal tumours, a thoracic and two abdominal ones, were localised by high catecholamine levels in blood from other veins draining into the IVC. Vanillylmandelic acid determinaion was unreliable in the diagnosis of small phaeochromocytomas.

Abdominal Neoplasms↗