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Biomedical subjects

J Bernard

Publications and source records attributed to J Bernard.

At least 217 records · Page 12Linked to original sources
PubMed1983

T-cell origin of Lennert's lymphoma. Immunohistochemical and immunologic study of one case.

We observed a patient with Lennert's lymphoma. Immunocytochemical study of paraffin sections by the immunoperoxidase technique and immunologic study of viable cell suspension by monoclonal antibodies confirmed the T-cell nature of the neoplastic lymphoid cells. Subtyping showed a predominance of helper T lymphocytes. The histiocytic nature of the epithelioid-cell component of Lennert's lymphoma was also shown by immunostaining.

Cell Transformation, Neoplastic↗
PubMed1983

[Phenotype of T lymphocytes and macrophages obtained by broncho-alveolar lavage of human lung].

T lymphocytes and macrophages, isolated and purified from broncho-alveolar lavages performed in normal controls and in patients with various alveolar structure diseases were identified using monoclonal antibodies against different membrane markers. For T lymphocyte subsets, our results are consistent with previous observations showing a large number of lung helper T cells in patients with sarcoidosis with high-intensity alveolitis. For macrophage subsets, we pointed out, for all cases, a weak expression of monocyte markers.

Antibodies, Monoclonal↗
PubMed1983

The chemical composition of lymphocystis disease virus of fish.

After concentration with PEG-6000 and purification on a metrizamide gradient, the Lymphocystis Disease Virus (LDV) can be shown as a particle with a chemical composition of 1,6% DNA, 42,3% protein and 17,1% lipid, most of them being phospholipids. Sugars might constitute a major portion of the 39% unidentified components.

Animals↗
PubMed1983

History of congenital hemorrhagic thrombocytopathic dystrophy.

This history is divided into three parts: The history of the first patient and of the first family studied. The natural history of the disease (epidemiology, clinical disorder, platelet disorder, evolution). The history of research that relates to the disease: a) Methods (morphology, physiology, biochemistry, immunology). b) Concepts.

Blood Coagulation Disorders↗
PubMed1983

[Familial and recurrent hyperparathyroidism. Apropos of 7 adenomas in 3 members of the same family. Review of the literature].

Over a period of 23 years, 3 members of a family of 5 presented with 7 parathyroid adenomas (4 in the first case, 2 in the second case, 1 in the third case). Excision of each adenoma, with systematic pre-operative assessment of the remaining parathyroid tissue, led to complete clinical and laboratory cure of each episode. The delay in the appearance of recurrence was between 3 and 9 years. After reviewing the literature, the authors stress the importance, in any case of hyperparathyroidism, of routinely investigating the serum calcium levels in members of the patient's family, especially if the patient is young and if he has had several episodes or a multiglandular involvement in the one episode. The authors discuss the literature concerning recurrent familial hyperparathyroidism with endocrine polyadenomatosis and the "hypercalcaemia - hypocalciuria" syndrome.

Adenoma↗
PubMed1982

Long-term cost of combined radiotherapy and chemotherapy.

Complications after treatment of Hodgkin's disease are a good model to evaluate the long-term cost of combined chemo- and radiotherapy. Secondary malignancies and mainly acute myelocytic leukemias are the main complications. The 35 of 1,889 cases reported represent increased risk by factor 129. Often preceded by a leukemic phase, they are of poor prognosis. Solid tumors are increased by factor 2.8. They may occur in patients treated by prolonged chemotherapy with alkylating agent without radiotherapy. In seven of 31 patients, solid tumors appeared in the irradiated area. Sterility in young males was present during the first year, though some recuperation was observed thereafter. Better adjustment of treatment to individual risk, to drug sensitivity, and active combinations devoid of alkylating agents are required to reduce the rate of these complications.

Antineoplastic Agents↗
PubMed1982

Poor-prognosis acute lymphoblastic leukemias.

Burkitt's-type leukemias have specific cytologic, immunologic, and cytogenetic characteristics. Initial symptomatology frequently includes abdominal tumors and initial CNS involvement. Despite intensive treatment including high-dose cyclophosphamide, prognosis remains poor in most patients because of failures to achieve complete remission (CR) or because of early relapses, especially CNS relapses. Class III acute lymphoblastic leukemia in children is defined by the presence of two or more unfavorable parameters and recent progress has been achieved by intensive therapy. Cox's multifactorial analysis allows improved discrimination. A phase I protocol for increased-risk leukemias, including testis preventive irradiation and monthly reinductions without continuous maintenance for the first 6 months of CR, seems promising.

Adolescent↗
PubMed1982

A general method for the cytochemical and ultrastructural studies of human lymphocyte subsets defined by monoclonal antibodies.

After incubation with monoclonal mouse antisera raised against membrane differentiation antigens, subsets of human lymphocytes can be detected by means of latex microspheres or ox erythrocytes coated with anti-mouse Ig antibodies. Optimal conditions are described using a panel of monoclonal antisera (Ortho Pharmaceuticals and New England Nuclear). The method is as sensitive as the complement-mediated microcytotoxicity assay, is rapid, easy to perform and permits exhaustive light and electron microscopic studies of lymphocytes bound to the carrier particles. The advantages of the simultaneous analysis of cytological features and monoclonal antibody-defined surface markers in normal and pathological individual lymphocytes are discussed with regard to lymphoid cell maturation and neoplastic lymphocyte classification.

Animals↗
PubMed1982

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History, Modern 1601-↗