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Biomedical subjects

J Berger

Publications and source records attributed to J Berger.

At least 415 records · Page 23Linked to original sources
PubMed1982

Treatment of protracted bilateral mandibular dislocation with Proplast-Vitallium prostheses.

A case of bilateral protracted mandibular dislocation complicated by the presence of unusual degenerative changes in the temporomandibular joints is presented. A synopsis of treatment modalities that have been used previously to treat similar conditions is given. Our treatment consisted of bilateral condylectomies, eminectomies, and insertion of Proplast-coated Vitallium condylar prostheses. These procedures resulted in the re-establishment of normal TMJ anatomy, the maintenance of proper posterior mandibular vertical dimension, correction of malocclusion, and relief of the patient's symptoms.

Adult↗
PubMed1982

A quantitative study on the recovery of rat marrow erythropoietic cells after experimental suppression of erythropoiesis by repeated doses of cyclophosphamide.

Rat erythropoiesis was experimentally depressed by repeated doses of cyclophosphamide (CY) or by restriction of food consumption and the diagnostic value of quantitative haematology examinations of rat marrow erythroid morphology was evaluated. A slight depression of rat erythropoiesis (following a dose of 5 mg/kg/day) as well as a higher one (15 mg/kg/day) and the following recovery were determined by a quantitation of marrow erythroid morphology and by peripheral reticulocyte counts, yet a lower validity of peripheral erythrocyte and marrow relative erythroid cell counts was obtained; erythrocyte counts did not change even after a high depletion of marrow erythroid cells. The restriction of food consumption led to a similar depression of rat marrow erythropoiesis as that observed after CY administration. Our data may suggest that the quantitation of marrow erythroid morphology and peripheral reticulocyte counts are desirable in haematological examinations in preclinical safety evaluations performed on rats provided a new drug administered in repeated doses can be cytotoxic.

Animals↗
PubMed1982

A quantitative study on recovery from acute haemorrhage in adult laboratory rats. I. Blood morphology.

We evaluated changes in blood morphology for detecting acute blood loss in laboratory rats. Haematologic indices which are normally used in investigating drug effects on rat blood morphology were examined. Sublethal acute blood loss (25 ml per kg body weight) modified rat blood morphology in a few minutes; the blood picture was normal within two weeks. Blood drawing (usually up to 10 ml per kg b.w.) can modify rat blood morphology within one week. Erythrocyte counts, haemoglobin concentration and haematocrit decreased earliest, reticulocyte counts were changed longest. Comparing our results and literature data the recovery of blood morphology from acute haemorrhage seems to be more rapid in rats than in men.

Animals↗
PubMed1982

A quantitative study on recovery from acute haemorrhage in adult laboratory rats. II. Bone marrow, spleen and liver morphology.

We investigate bone marrow, spleen and liver morphology in adult laboratory rats following acute haemorrhage to establish their validity in preclinical studies, especially in safety drug evaluations. The most marked changes were found in the proportion of spleen erythroid nucleated cells. Higher E: M ratios and relative erythroid cell counts were also marked in the bone marrow. Their increase was not so intensive and disappeared earlier than the increase of spleen erythropoiesis. Variations in counts of marrow neutrophils and their precursors were not specific.

Acute Disease↗
PubMed1982

The segmentation of nuclei in circulating neutrophils of laboratory rats.

In normal rats, we determined Edwin's (35 +/- 5) and modified (1 +/- 0) segmentation indices, Hynek's numbers (3.2 +/- 0.0) and neutrophil counts with different numbers of nuclear lobes (more than 99 per cent of neutrophils had 2-5 lobes and 0.6 +/- 0.4 per cent of neutrophils had 6 or more nuclear lobes). Neutrophil counts with 6 or more nuclear lobes seem to be sufficient for determination of experimental induction of hypersegmentation in rat neutrophils.

Animals↗
PubMed1982

Oxfendazole: anthelmintic activity in calves artificially infected with six species of nematodes and in calves naturally infested with tapeworms.

In a series of 5 trials, in which 115 artificially infected calves were used, larval anthelmintic tests were done to assess the activity of oxfendazole at 4, 5 mg/kg against all 3 parasitic stages of 6 species of namatodes. An efficacy of over 98% was demonstrated against the 4th stage larvae (L4), 5th and adult stages of Haemonchus placei, Ostertagia ostertagi, Cooperia pectinata, Bunostomum Phlebotomum and Oesophagostomum radiatum and the 3rd larval stage (L3) of H. placei and C. pectinata. Against the L3 of O. ostertagi, B. phlebotomum and O. radiatum efficacies of 81,7%, 92,4% and 97,3% respectively were shown. Against Dictyocaulus viviparus adult, 5th, L4 and L3 efficacies were recorded of 100%, 96,7%, 95,4% and 89,1% respectively. A test for ovicidal activity confirmed that cattle can be safely moved to clean pasture 8 hours after dosing. Complete removal of strobilia of Moniezia benedeni from 25 naturally infested calves followed a dose rate of oxfendazole at 4,5 mg/kg, but of these each of 4 calves retained one scolex.

Animals↗