Biomedical subjects
Publications and source records attributed to J Berger.
The use of electrocautery and topical thrombin at the donor and recipient sites has decreased most of the oozing normally present in skin graft vestibuloplasty procedures. It has effectively reduced operating room time, has significantly reduced post-operative morbidity, and has shortened both hospital stay and recovery time for the patient.
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The marrow haemopoietic recovery started without a previous lymphocyte influx. Marrow lymphocytic regeneration followed this process in erythropoietic and granulopoietic series. Lymphocyte regeneration in rats was more rapid after evening cyclophosphamide injection.
Within the granulopoietic recovery phase the proportion of neutrophils and their precursors in the spleen was elevated from 1.7 +/- 0.3% (controls) to 14.7 +/- 2.2% (on day 14 after cyclophosphamide). Splenic granulopoiesis persisted for a time after the appearance of marrow recovery. These data suggest that the rat adult spleen can become a markedly granulopoietic organ during the regeneration of granulopoiesis which follows experimentally induced myelosuppression.
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A score test for the null hypothesis of proportional hazards against rank-regression alternatives is proposed as a complement to the logrank test for comparing censored survival curves. The test statistic has an asymptotic normal distribution that is independent of the logrank distribution under the null hypothesis, and its power is good against acceleration alternatives (i.e. with crossing hazards) where the logrank test fails. Monte Carlo studies indicate that its small-sample properties are comparable to those of the logrank and ranksum procedures.
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The first Australian case of acquired immune deficiency syndrome (AIDS), which occurred in a 27-year-old homosexual man, is reported. The patient, an American citizen now resident in Sydney, presented with life-threatening pulmonary consolidation. AIDS is characterized by severe defects in cell-mediated immunity associated with infections and neoplasms (most commonly Pneumocystis carinii pneumonia and Kaposi's sarcoma). The cause of the syndrome is unknown, but it may be a new infectious agent.
Twenty-three (9 male, 14 female) wild horses (Equus caballus) in the Great Basin Desert were immobilized by ground techniques with succinylcholine chloride during 1,950 person-hr. Induction (means = 2.09 +/- 0.59 min) and recovery (means = 12.4 +/- 5.0 min) were rapid and most animals were returned in less than 10 min to original bands. Dosages ranged from 0.66-0.77 mg/kg body weight and neither abortions nor band changes in group membership resulted. However, a few concerted efforts up to 24 hr were needed to return some animals to original bands and three non-drug related mortalities occurred. The responses of bands to darted members and the overall influence of the operation on reproduction, movements, and social structure are presented.
Total leukocyte, erythrocyte, absolute lymphocyte, eosinophil and segmented neutrophil counts in the peripheral blood of SPF rats kept under light/dark 12 h/12 h cycles were investigated with respect to a time standardization of blood drawing for haematological examinations in long-term studies, especially in preclinical safety evaluations of new drugs. Mesor and amplitude were subject to seasonal variations in the circadian rhythm of leukocyte, absolute lymphocyte, segmented neutrophil and eosinophil counts. Variations in erythrocyte counts were sometimes statistically significant but they were moderate and no circadian rhythm was evident. Thus, examinations of the rat blood picture during biomedical studies have to be related to the pertinent time of circadian clocks and in long-term studies also to the time of season.
There were slight and rapidly disappearing changes in the bone marrow and blood morphology of laboratory rats after repeated bleedings on consecutive days, except marked increases in the counts of circulating reticulocytes. However, the significantly elevated reticulocyte count was not accompanied by the similar increase in the count of marrow erythroid nucleated cells. Marked increments could be found in the counts of splenic erythroid nucleated cells and, therefore, it is possible for rat circulating reticulocytes to originate following repeated bleedings from the spleen. The validity of investigations of bone marrow and blood morphology for detecting haemorrhage is discussed with a view to preclinical safety drug evaluations performed on adult laboratory rats.
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