Biomedical subjects
Publications and source records attributed to J Beer.
Data from 31 children (age 10.7 yr.) of divorced parents showed lower self-concept scores on the Piers-Harris Children's Self-concept Scale than 19 children of nondivorced parents, although the two sets of scores fall within the expected range.
123 high school students completed the short form of the Coopersmith Self-esteem Inventory-School Form and its Lie scale, Beck's Depression Inventory, and an Alcohol Dependency Scale. Analyses of variance (2 x 4) showed boys had higher mean Lie scores than girls, and freshmen had lower mean alcohol dependency scores than sophomores, juniors, and seniors. Correlations between self-esteem scores and depression scores were significant and negative, but values were significant and positive between self-esteem and lie scores and between depression and alcohol dependency scores. Much work is required to understand better the relations among depression, self-esteem, and drug and alcohol dependency in high school students if interventions are to focus upon prevention.
61 children (33 in Grade 5 and 28 in Grade 6) participated and were administered the Piers-Harris Self-concept Test, the Coopersmith Self-esteem Inventory--School Form, and the Children's Depression Inventory. At the end of the school year grade point averages (GPAs; 12-point scale) were calculated and Iowa Tests of Basic Skills were taken from their transcripts. Among the 58, 21 children were from divorced homes (10 girls and 11 boys) and 37 were from nondivorced homes (21 girls and 16 boys). Other subjects' data were not used because some data were missing. Children from divorced homes scored significantly lower on the self-concept test, self-esteem tests, and GPAs than children from nondivorced homes, although both scores would be considered average. Girls had significantly higher GPAs than boys. Children from divorced homes scored significantly higher on the Children's Depression Inventory than children from nondivorced homes, but there were no significant effects for the composite score from the Iowa Tests of Basic Skills for marital status of parents. Present results agree with prior observations that divorce has negative effects upon the children involved.
This paper reports on the kinetic and thermodynamic parameters describing the interaction of selected digitalis derivatives with hog and guinea-pig cardiac (Na+ + K+)-ATPase (Na+/K+-transporting ATPase EC 3.6.1.37). 32 digitalis derivatives were characterized as to the values of the delta G0', delta G----not equal to, and delta G----not equal to quantities in their interaction with (Na+ + K+)-ATPase from hog cardiac muscle in the presence of ATP, Mg2+, Na+ and K+. Nine derivatives were additionally characterized as to the values of the delta H0', delta S0', delta H----not equal to, delta S----not equal to, delta H not equal to, and delta S not equal to quantities in their interaction with the hog enzyme promoted by ATP, Mg2+ and Na+ in the presence or absence of K+. The formation of the inhibitory complexes is in any case an endothermic, entropically driven process. The Gibbs energy barriers in the formation and dissociation of the complexes, delta G----not equal to and delta G----not equal to, are imposed by large, unfavourable delta H not equal to values. K+ decreases the delta G0' value by increasing the delta G----not equal to value more than the delta G----not equal to value. In comparison with hog (Na+ + K+)-ATPase, the interaction of three derivatives with guinea-pig cardiac enzyme in the presence of ATP, Mg2+, Na+ and K+ is characterized by lower delta G0' values caused by lower favourable delta S0' values, and is accompanied by lower delta G----not equal to values. The magnitude of the kinetic parameters and the characteristic of the thermodynamic quantities describing the interaction between various digitalis derivatives and (Na+ + K+)-ATPase, indicate the induction of substantial conformational changes in the enzyme protein. A large entropy gain in the enzyme protein, observed irrespective of enzyme origin and ligation, appears to be the common denominator of the inhibitory action of all digitalis derivatives studied, suggesting that the digitalis-elicited relaxation of high conformational energy (negentropy strain) of the enzyme protein is the thermodynamic essence of the reversible inactivation of (Na+ + K+)-ATPase.
Light-eyed individuals generally perform better at self-paced activities while dark-eyed individuals perform better at reactive activities. Using multiple regression it was found that dark-eyed students hit a target with a frisbee more times than did light-eyed students.
30 subjects volunteered from three sources: community adults (M age = 32.8, SD = 13.4), college adults (M age = 23.8, SD = 8.3), and children (M age = 9.5, SD = 1.7) and were categorized as 'left-' and 'right-dominant' by scores on Your Style of Thinking and Learning. They reported the number of Necker cube reversals perceived in 90 sec., attempted to locate four embedded figures, and blindly traversed a 16-choice point finger maze in that order. 'Right-dominant' subjects located more embedded figures and made fewer errors on the finger maze than did 'left-dominant' subjects. College adults reported more Necker cube reversals than did community adults and children, and community adults reported more reversals than did children. Confounds of performance measures with fatigue and/or practice require further research.
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Four cases of myocardial infarction after termination of anticoagulant therapy are presented. The controversy on the clinical relevance of the "rebound-phenomenon" is discussed: although laboratory parameters seem to suggest a rebound, the phenomenon may be of clinical importance only in certain subpopulations at risk. In these patients withdrawal of the anticoagulant therapy should be gradual.
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The nearly fatal outcome of a case of chloroform sniffing is described. After a brief review of the organ toxicity of chloroform, a potential therapeutic approach is discussed. Inhalation anesthetics should be considered in the differential diagnosis of coma of unknown etiology in the adolescent.
The fluxes of the nuclear component of the galactic cosmic radiation are discussed in terms of energy spectra for the different elements. Influences of shielding by the earth's magnetic field on these spectra are described. Then energy spectra behind absorbing matter are calculated considering energy loss and fragmentation. Based on these energy spectra LET-spectra are calculated. The form of the LET-spectra and their dependence on the composition of the shielding material are discussed. For LET-spectra measured by different detectors the restricted energy losses are converted to LETinfinity. in water. After this it is possible to compare the results of different experiments with each other and with calculated LET-spectra.
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Friedrich Loeffler's discovery of the pathogen of foot and mouth disease actually ushered in the era of virus research on man and animal and gave birth, at the same time, to efforts for immunoprophylaxis against the disease. This led directly to the foundation of the world's first virological institute on Riems Island. A brief account is given of the developments that have taken place up to our days in research and production at Friedrich-Loeffler Institute for Epizootiological Research on Riems Island. The Institute is affiliated to the Academy of Agricultural Sciences of the German Democratic Republic. The importance of immunoprophylaxis to prevention and control of infectious diseases among agricultural animals has grown on the basis of present microbiological knowledge and along with progress in livestock production. This concept is explained in greater detail, and aspects of fundamental importance to appropriate research are expounded.
The [3H]-ouabain-(NaK)-ATPase complex when treated in the cold with sodium dodecyl sulfate (SDS) dissociates into a larger and smaller peptide called alpha and beta, resp.. Analysis of the released peptides by SDS-polyacrylamide gel electrophoresis reveals that [3H]-ouabain co-migrates with the alpha-peptide only, being apparently identic with the ouabain receptor molecule. The percentage occupancy of the receptor peptide with [3H]-ouabain can be increased up to 90% evidencing the stabilization of the [3H]-ouabain-alpha-peptide complex by SDS-exposure and release from the oligomeric enzyme. A hypothetic explanation for the seemingly paradoxical stabilising effect of SDS on the complex is offered.
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