[Growth and puberty in Turner syndrome].
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Adolescent↗
Biomedical subjects
J Battin
Publications and source records attributed to J Battin.
Infantile acute hemorrhagic edema of the skin: study of ten cases.
Infantile acute hemorrhagic edema of the skin is not included as a separate entity in the current English-language literature as it is in continental Europe. Therefore we have attempted to clarify the nosologic position of acute hemorrhagic edema among cutaneous vasculitides in children, on the basis of our experience in 10 cases. Our study confirms that acute hemorrhagic edema affects infants between 4 and 24 months of age. The two main features are an ecchymotic purpura, often in a cockade pattern, and an inflammatory edema of the limbs and face. Visceral involvement is uncommon. Spontaneous and complete resolution occurs within 1 to 3 weeks; one to four attacks may occur. Histopathologic examination demonstrates a leukocytoclastic vasculitis. Perivascular IgA deposits can occasionally be found. Besides typical acute hemorrhagic edema, some cases in 2- to 4-year-old children appear to overlap with Schönlein-Henoch purpura. We suggest that typical acute hemorrhagic edema should be regarded as a separate clinical entity. This allows an appropriate prognosis to be made for this generally benign disease of infants.
Acute Disease↗
Proteus syndrome in 7 patients: clinical and genetic considerations.
The Proteus syndrome is a congenital hamartomatous disorder delineated in 1983. Because of its polymorphic appearance, the syndrome was named after the greek god Proteus whose name means much less than the polymorphous much greater than. Major clinical findings include hemi hypertrophy, macrodactyly, exostoses, scoliosis, epidermal nevi, haemangiomas, deeply rugated soles of the feet and a variety of deep and subcutaneous masses. We report on 7 new cases of Proteus syndrome. All reported cases have been sporadic. Therefore this syndrome could be due to the action of a dominant lethal gene surviving by mosaicism.
Adult↗
Medulloblastoma in the nevoid basal-cell carcinoma syndrome: case reports and review of the literature.
The nevoid basal-cell carcinoma syndrome (NBCCS) is a rare autosomal-dominant inherited disorder. Its clinical manifestations are multiple basal-cell nevi and cysts of the jaw along with skeletal anomalies and various combinations of numerous other defects. NBCCS is characterized by a marked propensity for developing cancers. One of the most frequently reported tumour is brain medulloblastoma. We are reporting two cases of NBCCS and medulloblastoma. A review of the case reports demonstrates certain prominent features of medulloblastoma associated with NBCCS. The patients generally are males, presenting at an unusually young age, under 5 or 2 years and show a longer survival rate. Its lay down to search for NBCCS in early medulloblastoma's, especially under 2 years.
Adolescent↗
[Development of the prevalence rate of four intestinal parasites in children].
During the last 2 decades, the same coprological techniques for the detection of parasites have been applied by the same team in the parasitology laboratories of the Children's Hospital of Bordeaux. A marked decrease in the prevalence of the most frequently occurring parasites (Giardia and Entamoeba coli cysts, Ascaris and Trichocephale eggs) has been observed. Similar results have also been found in other French parasitology laboratories. This reduction in the parasite infection rate is concomitant with a sustained improvement in public hygiene and the living standards of families. It is also likely that an evolution in childhood behaviour at school, outdoors, and at home, accounts for a decrease in intestinal parasites.
Adolescent↗
[Neonatal primary hyperparathyroidism, parathyroid adenoma, chromosomal deletion: an approach to localizing the gene?].
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Adenoma↗
[Etiologic and biologic heterogeneity of growth hormone deficiency: significance of neuro-secretory dysfunction].
The pharmacological tests and the 24 hours secretion permitted to accept 96 cases among a group of 301 children with short stature. The aetiologic parameters are numerous. There are too a great heterogeneity for the diagnostic criteria of GH deficiency: severe or partial, concordant or discordant between the two biologic methods with a new variety called neuro-secretory dysfunction with normal pharmacological tests and poor endogenous secretion.
Adolescent↗
[Thyroglobulin and thyroid pathology in children].
Thyroglobulin, a marker for thyroid vesicles, is a normal constituent of serum. For the last ten years, thyroglobulin has been routinely assayed using a radioimmunologic double antibody technique. In children, normal values are usually under or equal to 30 ng/ml. Neonates have higher levels. The main indications of thyroglobulin assays in pediatrics include diagnosis of metastases of differentiated thyroid epitheliomas and etiologic diagnosis of congenital hypothyroidism. Thyroglobulin assays are less helpful in the other childhood thyroid diseases (goiter, hyperthyroidism).
Carcinoma↗
[Allergy and desensitization to hymenoptera venom in children].
Among 15 children who were stung by hymenoptera, 5 underwent semi-rapid desensitization using the outpatient Molkhou method. This technique was well tolerated; desensitization was stopped when protective IgG levels measured by RIP (radioimmunoprecipitation) reached 50% and skin tests and RASTs became negative. In a comparable series of adults, however, discontinuation of the desensitization was considered only following satisfactory tolerance of an accidental or planned sting. In children, semi-rapid desensitization is very effective and has also been proposed for allergies to air borne allergens such as mites and pollens when increased doses are required to improve protection.
Adolescent↗
[Acute infectious cellulitis. Apropos of 28 cases].
Acute infectious cellulitis is a common condition in pediatric patients. We retrospectively studied 28 cases seen over the last four years. Average age of patients was four years. Fever and a decline in general health were often found. Streptococcus pyogenes and Staphylococcus aureus were the most common organisms in our series. Outcome was favorable under early antimicrobial therapy selected according to age and clinical features. Before three months of age, cellulitis suggests a streptococcus B infection and should be treated by ampicillin or parenteral penicillin, combined with an aminoglycoside if called for. Between 4 months and 2 years of age, Haemophilus influenzae b or a pneumococcus are the most likely organisms; Haemophilus cellulitis should be treated by a third generation cephalosporin for ten days or longer, followed by ampicillin or ampicillin-clavulanic acid per os for ten or 15 days. Beyond 2-3 years of age, all organisms may be the cause of cellulitis, but the most likely are Streptococcus pyogenes and Staphylococcus aureus, treatment consists in administration of either a penicillin M or a macrolide, the route being selected according to the general condition and site of the cellulitis.
Acute Disease↗
[Acute myelomonocytic leukemia with eosinophils. Apropos of a case with a cytogenetic analysis and nosologic discussion].
Report of overwhelming leukemia with meningeal involvement in a 13-year-old. Cytologic and ultrastructural examinations showed features of myelomonocytic leukemia with abnormal eosinophils. The karyotype showed pericentric inversion of chromosome 16. Although these findings establish the diagnosis of acute myelomonocytic leukemia with abnormal eosinophils (M4Eo), this case ran an exceptionally severe course and exhibited some unusual cytologic features.
Adolescent↗
[Fatal myocardiopathy due to adriamycin in spite of a reportedly non-dangerous cumulative dose].
We report a case that illustrates the risk of major, irreversible heart failure despite theoretically safe cumulative doses of adriamycin. We discuss risk factors for cardiotoxicity, predictive methods among which echocardiography is the most useful, and preventive measures. Data are still lacking concerning long term consequences on cardiac function. Until less cardiotoxic adriamycin derivatives become available, modifications in the treatment regimen can be proposed, including a tolerance test, lower doses approximating 20 mg per week instead of 60 mg every three weeks, and administration by continuous infusion through a deep catheter or a pump as cardiotoxicity seems more dependent on drug level peaks than on total dose. These measures should reduce the hazards of adriamycin, a drug that also has potent antimitotic properties.
Cardiomyopathies↗
[Fertility in Turner's syndrome and the risk for offspring].
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Female↗
[De novo del (13) (q31.1----qter) in a girl. Effect of gene dosage on blood coagulation factors VII and X].
Partial deletions of chromosome 13 are heterogeneous. The authors describe a girl with a large terminal deletion.
Abnormalities, Multiple↗
[Benign tumors of the ovary and follicular cysts in children and adolescents].
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Adolescent↗
Congenital malformations and chromosomal aberrations.
Among a great number of chromosomal aberrations, the absence of cerebral malformations does not explain the reason for mental retardation and will lead to interpreting as normal the echography of a fetus which, after birth, will be revealed to have a trisomy. Trisomic brain anomalies are not constant or obligatory, but some of them (holoprosencephaly for 61% of trisomy-13 and agenesis of corpus callosum for 8% of trisomy-18) have a degree of specificity. As for cerebral and cerebellar heterotopias, they cannot be considered as real malformations as they are frequently found in premature newborns and disappear with maturation, thus proving that they are a sign of immaturity. There is still a lot of work to be done before we are able to meet the request for fetal integrity formulated by contemporary couples.
Brain↗
[Utero-ovarian echography during normal development and in sexual precocity].
Utero-ovarian ultrasonography provides biometric data concerning internal female sexual organs. The length of the uterus provides the best indication of estrogen impregnation. This low-cost, non-invasive examination is suitable for an initial investigation of whether the uterus is stimulated at the normal age or prematurely. The method can be used to monitor the advance of puberty as well as the effects of therapy, surgery, slowing by LH-RH analogs, puncture under ultrasound of a secreting follicular cyst. Follicular cysts of this type are now found to be very common, thanks to the possibilities offered by ultrasonography.
Adolescent↗
[Plasma thyroglobulin in treated hypothyroidism in children].
In order to appreciate the value of the dosage of thyroglobulin (Tg) in the reappraisal of the classification of hypothyroidism after the onset of substitutive treatment and the supervision of patients treated with L-thyroxin (LT), plasma Tg and FT4 levels were studied in 42 samples from 21 hypothyroid children (ages ranging from 18 months to 16 years) under LT treatment. These patients were divided into 2 groups according to the results of scanning: group I: a thyroid (n = 8) and group II: ectopic or hypoplastic thyroid gland (n = 13). A control group consisted of 60 apparently healthy children of the same ages. Tg was undetectable in 11 samples of 6 children but significant levels (6.8 to 17 ng/ml) were found in 5 samples of 2 children. In group II, Tg could be measured in 20 of 26 samples, the mean level (+/- SEM) not being different from that in the control group (14.32 +/- 2.25 and 18.12 +/- 1.28 ng/ml, respectively). However, in this group, Tg levels seemed to be lower (9.75 +/- 3.94 ng/ml) in samples from patients with LT excess than in euthyroid or hypothyroid patients whose values of Tg were 15.8 +/- 3.36 ng/ml and 16 +/- 3.91 ng/ml, respectively.
Adolescent↗