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Biomedical subjects

J Barry

Publications and source records attributed to J Barry.

At least 145 records · Page 8Linked to original sources
PubMed1979

Craniosynostosis: correlation of bone scans, radiographs, and surgical findings.

Skull scintigraphy was performed in 68 children with suspected craniosynostosis after injection of technetium-99m methylene diphosphonate. The scans demonstrated four patterns of sutural activity: normal, absent, increased, and wide. When correlated with surgical findings, "absent" indicated fused sutures, "increased" indicated fusing hyperactive sutures or sutures reacting to fusion elsewhere, and "wide" indicated splite sutures. Upon correlation with the radiographs, it was found that when the radiograph was normal, the scan contributed little; when the radiograph was abnormal or equivocal, the scan was often of great assistance in confirming fused sutures and detecting other abnormal sutures.

Child, Preschool↗
PubMed1979

[Periodic modifications of the preoptico-terminal LRH tract in the squirrel monkey during the estrous cycle (author's transl)].

The quantities of specific immunoreactive material along the preoptico-terminal LRH tract show important modifications during the estrous cycle in the squirrel monkey. During the late follicular phase and the peri-ovulatory period the preoptico-terminal LRH tract shows "low" or "very low" fluorescence intensity. A progressive but very important increase occurs during the luteal phase, followed by great variations during the early and middle follicular phases. These variations suggest a conspicuous release of LRH, especially during the middle follicular phase. It is supposed that the preoptico-terminal LRH tract (whose LRH is released into the capillaries of the vascular organ of the lamina terminalis and reaches the systemic blood) controls gonadotropic cell sensitivity to the preovulatory discharge of the hypothalamo-infundibular LRH tract, and perhaps also gonadotropins synthesis.

Animals↗
PubMed1978

Immunofluorescence study of the hypothalamo-infundibular LRH tract and serum gonadotropin levels in the female squirrel monkey during the estrous cycle.

The study of LRH reactive neurons of the medial basal hypothalamic group was made with rabbit antisera to unconjugated synthetic LRH, in normally cycling female squirrel monkeys. The specifically immunoreactive material present along the hypothalamo-infundibular LRH tract shows significant modifications that are particularly distinct in the lateral, posterior and anterior labia of median eminence, with a maximum concentration during the early and middle follicular phases, a sudden fall to a minimum concentration during the late follicular and ovulatory phases and with a progressive increase during the luteal and early follicular phases. Serum FSH and LH levels show a progressive decrease from the luteal phase to the late follicular phase, with differential modifications suggesting that a double regulation might take place in cycling squirrel monkeys. A parallel is suggested between the specifically reactive material along the hypothalamo-infundibular tract, serum gonadotropin levels and variations in the medial basal hypothalamic and infundibular LRH concentrations during the estrous cycle in the squirrel monkey.

Animals↗
PubMed1978

Natural history of asymptomatic coronary arteriographic lesions in diabetic patients with end-stage renal disease.

Arteriosclerotic heart disease is a major cause of death in insulin-requiring juvenile diabetic patients treated for end-stage renal disease. Eleven consecutive diabetic patients without clinical evidence of coronary artery disease underwent complete cardiac evaluations, including coronary arteriography, as part of transplant recipient work-ups. Seven were women and four were men; their mean age was 32 (21 to 50 years). Angiographically, every patient had multifocal atherosclerotic coronary disease. Four of seven patients tested had positive-stress electrocardiograms. In this group of patients followed for a mean of 19.8 months, eight died. Of these deaths, six were due to coronary heart disease and another due to a stroke. In two patients who became clinically symptomatic, serial angiograms revealed progressive disease of the coronary circulation; in one case, despite normal renal allograft function and serum lipid levels. The mode of end-stage renal disease treatment, serum lipids or blood pressure control could not be linked to mortality. It is concluded that arteriosclerotic heart disease is common in diabetic patients with end-stage renal disease even when angina is absent. The natural history in this high risk population is an important consideration in the selection of patients for end-stage renal disease treatment.

Adult↗
PubMed1978

The effect of sectioning auditory centrifugal fibers on the cochlear microphonic and action potential in guinea pigs.

This investigation on 8 guniea pigs determined the immediate effect on the cochlear microphonic (CM) and action potential (AP) of ipsilateral sectoning of the autitory centrifugal fibers. An acoustic signal was used to evoke the CM and AP of one ear of guinea pig and the homolateral olivo-cochlear bundle and lateral lemniscus were then sectioned. Differences between pre- and post-section CM and AP were measured. The results demonstrated an increase in the CM and a decrease in the AP in all animals. Speculation with regard to the overall function of the auditory centrifugal system was offered.

Action Potentials↗
PubMed1977

Immunofluorescence study of LH-RH producing cells in the human fetal hypothalamus.

The use of antibodies to synthetic LH-RH has enabled the detection by immunofluorescence of hypothalamic LH-RH producing cells in the human fetus. The perikarya of these cells are located in the pericommissural and peroptic regions, in the lamina terminalis and in the premamillary region. Reactive axons occur in the median eminence. The first LH-RH producing cells are seen as early as nine weeks of gestation. The specificity of immunocytological reaction has been controlled.

Axons↗
PubMed1977

Immunofluorescence study of LRF neurons in man.

Human LRF neurons were characterized by immunofluorescence, using rabbit immunesera against unconjugated synthetic LRF, previously adsorbed on polyvinylpyrrolidone. These neurons, which vary in number from one specimen to another, are mainly concentrated in the mediobasal hypothalamus (infundibular and premammillary nuclei in particular) and in the lamina terminalis and the neighbouring preoptic area. The give rise respectively to a hypothalamo-infundibular LRF tract (ending around the capillaries of the primary portal plexus of the infundibulum) and to a preoptico-terminal tract (ending mainly around the capillaries of the primary and secondary plexuses of the vascular organ of the lamina terminalis and, in addition, between the ependymal cells lining its ventricular surface). It is suggested that these two tracts could be implicated in the tonic and cyclic control of gonadotropic secretion. Some reactive neurons are also present in the septal and pericommissural regions and in the retromammillary area and rostral mesencephalon. These neurons give rise to various extrahypophyseal LRF tracts, probably ending in the telencephalon and the brainstem. It is suggested that LRF, in addition to its major "prehypophysiotropic" action, is able to modulate the activity of certain telencephalic or mesencephalic structures.

Adult↗