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Biomedical subjects

J Barrat

Publications and source records attributed to J Barrat.

At least 145 records · Page 8Linked to original sources
PubMed1978

[Neuropathology and pregnancy. 189 consecutive cases (1971--1976) (author's transl)].

The authors report 189 case histories of pregnant women who had a neurological disorder, which either existed before the pregnancy or were discovered during the pregnancy. The most frequent aetiological conditions were, epilepsy, psychoses, vascular accidents, tumours and disseminated sclerosis. Pregnancy and neuropathology are an association for which the prognosis as a whole is good and linked to the time in the pregnancy when the neurological condition, whether it is stable or not, is discovered. The combination is absolutely compatible with the normal progress of pregnancy so long as the appropriate treatment is continued during the pregnancy. Cerebral vascular accidents that occur in pregnancy make the prognosis very much worse. In these circumstances neurosurgery may give some hope. This applies also for cerebral tumours, among which pituitary adenoma is becoming more and more frequent. Psychopathies can be a very baffling chapter when they are combined with pregnancy. Finally disseminated sclerosis, once it has been stabilised, is perfectly compatible with the normal outcome for a pregnancy.

Abortion, Therapeutic↗
PubMed1977

[Turner's syndrome phenotype and spontaneous menstruation. Apropos of a case of 45 X syndrome].

The authors report a new case where a women of 28 years of age started periods spontaneously in spite of having the phenotype of Turner's syndrome and a 45 X karyotype in her lymphocytes and fibroblasts. When she had been stimulated with Clomiphene it was even possible to prove that she had ovulated and produced a functional corpus luteum. No Barr bodies were to be found in the cells from her ovaries and the karotype did not suggest a mosaic which would normally explain this sort of state. All the same, it is difficult to see how any part of the basic follicles can persist in cases of monosomy 45 X if there is no mosaicism.

Adult↗
PubMed1977

[Pneumoperitoneum of genital origin. Apropos of a case at the beginning of pregnancy].

The authors studied the literature for similar findings in order to try to classify the different types of pneumoperitoneum when they had a case of pneumoperitoneum of genital origin. They then went on to study the mechanism by which these rare cases of genital pneumoperitoneum occurred: the insufflation or aspiration of air through the tubes, tubal antiperistalsis and uterine or vaginal perforations. From the clinical angle it is essential to eliminate pneumoperitoneum secondary to perforation of a hollow organ, and then to look for signs of peritonitis which only occur in genital pneumoperitoneum due to uterine perforation. The case usually cures spontaneously but recurrences are not uncommon. If there are no signs of peritonitis expectant treatment should usually be undertaken.

Abortion, Induced↗
PubMed1975

[Prolactin adenoma. Hypophysectomy during pregnancy].

The authors report a case of amenorrhoea with galatorrheoa due to a prolactin adenoma secondary to an inducer of ovulation (HMG and HCG) and in which pregnancy occurred. There was sudden progression of the adenoma with formation of a haematoma and the necessity for emergency surgery. In the light of this case, the risks and indications of inducers of ovulation in the sterile woman complaining of amenorrhoea with galactorrhoea are discussed.

Adenoma↗
PubMed1975

[Diagnosis of pregnancy before the menstrual period is delayed. Interest of the determination of plasma chorionic gonadotropin (HCG) in fertility disorders].

Estimating plasma HCG levels in the last days of the menstrual cycle have very early diagnosis of pregnancy. In 86 cycles occurring in 65 women being treated for sterility the levels were estimated between the 10th and the 15th day following the low point in the temperature curve for the purpose of trying to estimate the practical use of this method. In 30 cycles studied one case of fertilisation took place and was confirmed by the evolution of a pregnancy. From the 11th day onwards with the exception of one solitary case the concentrations of HCG ranged between 15 and 405 mUl-2 degrees-IS-hCC/ml. These levels, therefore are higher than the apparent concentrations found in a group of women used as controls who were not pregnant (0 to 4.5 mUl/ml.). In 56 other cycles apparently normal periods followed on the expected date. All the same, the apparent concentration of HCG (2 to 32 mUl/ml) is far higher often than in the control group. The interference of LH in the level makes it impossible to decide between two hypotheses: whether raised levels of LH are associated with irregular menstrual function or with fertilisation, followed by premature expulsion of the oocyte.

Chorionic Gonadotropin↗
PubMed1975

[Drugs most frequently used during pregnancy and labor and their effects].

It is rather difficult to draw up a list of the drugs most frequently used during pregnancy, and to specify their action on the mother, the uterus ans the fetus bearing in mind the differences between them. This difficulty results in particular from the high number of drugs owing to: the frequency of prescriptions and selfmedication in the pregnant woman who suffers from numerous disorders, and the possibility of a pathology associated with the pregnancy or a pathology due to the pregnancy itself thereby defining the "high risk" pregnancy. On this background already modified by pregnancy, under the hold of numerous drugs, an anesthetic can be necessary in addition during labour or delivery, the frequency of which can be estimated as being approximately 20 per cent. It is not possible to study all therapeutic agents in a single communication. One can only evoke the influence of the most currently used drugs; analgesics, antibiotics, diuretics, sleeping tablets, anti-hypertensives and those aimed at the neuropsychiatric system (anti-depression agents, neuroleptics, tranquillizers) which are so frequently used at present. Finally, during labour the number of parturients who receive no drugs is rare: ocytocic and anti-spasmodic agents can also interfere with an anesthetic. All of these ideas which are more and more difficult to acquire are important to know. In fact the person in charge of the delivery must prescribe as little drugs as possible (in order to avoid multiple drug interference which is rather difficult to predict) knowing the possible action of drugs on the fetus (in order to allow best adaptation to life in our atmosphere after delivery) and foreseeing the possible necessity for an anesthetic. In his turn, the anesthetist should have a good knowledge of obstetrical physiology and pathology and the drugs capable of being used during pregnancy and labour in order to be able to choose the best adapted anesthetic. This emphasized the importance of a well integrated obstetrico-anesthetic team in which each member knows the problems of the other, with the aim of being the least possible noxious for the mother, and the future newborn, the fetus. This also emphasizes the necessity for anesthetists attached to the ostetrical unit, knowing like the obstetrician the histories of those women with "high risk" pregnancies. Obstetrical anesthetics cannot be improvised.

Analgesics↗